Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyGlucocorticoid receptor-like (DNA-binding domain) 8039031 3000068 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyNuclear receptor ligand-binding domain 8038695 3001442 SCOP2B (2022-06-29)
B [auth D]SCOP2B SuperfamilyNuclear receptor ligand-binding domain 8035649 3001442 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHormone_recepe3dzyA1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
Azf-C4e3dzyA2 A: few secondary structure elementsX: Glucocorticoid receptor-likeH: LIM domain-likeT: LIM domain-likeF: zf-C4ECOD (1.6)
B [auth D]Hormone_recep_1e3dzyD1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recep_1ECOD (1.6)
B [auth D]zf-C4e3dzyD2 A: few secondary structure elementsX: Glucocorticoid receptor-likeH: LIM domain-likeT: LIM domain-likeF: zf-C4ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00105Zinc finger, C4 type (two domains) (zf-C4)Zinc finger, C4 type (two domains)In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.Domain
B [auth D]PF00105Zinc finger, C4 type (two domains) (zf-C4)Zinc finger, C4 type (two domains)In nearly all cases, this is the DNA binding domain of a nuclear hormone receptor. The alignment contains two Zinc finger domains that are too dissimilar to be aligned with each other.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Retinoic acid receptor RXR-alpha
B [auth D]Peroxisome proliferator-activated receptor gamma
DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3')---
D [auth F]DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DCP*DTP*DTP*DTP*DGP*DAP*DCP*DCP*DTP*DAP*DGP*DTP*DTP*DTP*DG)-3')---
E [auth G],
F [auth E]
NCOA2 Peptide

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR001628Zinc finger, nuclear hormone receptor-typeDomain
IPR021780Nuclear/hormone receptor activator site AF-1Domain
IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
IPR000003Retinoid X receptor/HNF4Family
IPR050274Nuclear hormone receptor family NR2 subfamilyFamily
IPR001723Nuclear hormone receptorFamily
IPR000536Nuclear hormone receptor, ligand-binding domainDomain
IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
B [auth D]IPR001628Zinc finger, nuclear hormone receptor-typeDomain
B [auth D]IPR013088Zinc finger, NHR/GATA-typeHomologous Superfamily
B [auth D]IPR001723Nuclear hormone receptorFamily
B [auth D]IPR003077Peroxisome proliferator-activated receptor gammaFamily
B [auth D]IPR000536Nuclear hormone receptor, ligand-binding domainDomain
B [auth D]IPR003074Peroxisome proliferator-activated receptorFamily
B [auth D]IPR050234Nuclear hormone receptor family NR1 subfamilyFamily
B [auth D]IPR022590Peroxisome proliferator-activated receptor gamma, N-terminalDomain
B [auth D]IPR035500Nuclear hormone receptor-like domain superfamilyHomologous Superfamily
E [auth G],
F [auth E]
IPR010011Nuclear receptor coactivator, DUF1518Domain
E [auth G],
F [auth E]
IPR009110Nuclear receptor coactivator, interlockingHomologous Superfamily
E [auth G],
F [auth E]
IPR037077Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamilyHomologous Superfamily
E [auth G],
F [auth E]
IPR017426Nuclear receptor coactivatorFamily
E [auth G],
F [auth E]
IPR014935Nuclear receptor coactivator, receptor-binding domainDomain
E [auth G],
F [auth E]
IPR013767PAS foldDomain
E [auth G],
F [auth E]
IPR000014PAS domainDomain
E [auth G],
F [auth E]
IPR011598Myc-type, basic helix-loop-helix (bHLH) domainDomain
E [auth G],
F [auth E]
IPR014920Nuclear receptor coactivator, Ncoa-type, interlockingDomain
E [auth G],
F [auth E]
IPR035965PAS domain superfamilyHomologous Superfamily
E [auth G],
F [auth E]
IPR028822Nuclear receptor coactivator 2, basic helix-loop-helixDomain
E [auth G],
F [auth E]
IPR032565Nuclear receptor coactivator 2/3, DUF4927Domain
E [auth G],
F [auth E]
IPR036638Helix-loop-helix DNA-binding domain superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP19793
B [auth D]PharosP37231
E [auth G],
F [auth E]
PharosQ15596