3EHW

Human dUTPase in complex with alpha,beta-imido-dUTP and Mg2+: visualization of the full-length C-termini in all monomers and suggestion for an additional metal ion binding site

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3ehwb_	All beta proteins	beta-clip	dUTPase-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth Y]	d3ehwy_	All beta proteins	beta-clip	dUTPase-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth Z]	d3ehwz_	All beta proteins	beta-clip	dUTPase-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3ehwa_	All beta proteins	beta-clip	dUTPase-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3ehwc_	All beta proteins	beta-clip	dUTPase-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth X]	d3ehwx_	All beta proteins	beta-clip	dUTPase-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	dUTPase-like	8041064	3001957	SCOP2B (2022-06-29)
E [auth Y]	SCOP2B Superfamily	dUTPase-like	8041064	3001957	SCOP2B (2022-06-29)
F [auth Z]	SCOP2B Superfamily	dUTPase-like	8041064	3001957	SCOP2B (2022-06-29)
A	SCOP2 Family	dUTPase-like	8028685	4002970	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	dUTPase-like	8041064	3001957	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	dUTPase-like	8041064	3001957	SCOP2B (2022-06-29)
D [auth X]	SCOP2B Superfamily	dUTPase-like	8041064	3001957	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	dUTPase	e3ehwB1	A: beta barrels	X: beta-clip	H: dUTPase-like (From Topology)	T: dUTPase-like	F: dUTPase	ECOD (1.6)
E [auth Y]	dUTPase	e3ehwY1	A: beta barrels	X: beta-clip	H: dUTPase-like (From Topology)	T: dUTPase-like	F: dUTPase	ECOD (1.6)
F [auth Z]	dUTPase	e3ehwZ1	A: beta barrels	X: beta-clip	H: dUTPase-like (From Topology)	T: dUTPase-like	F: dUTPase	ECOD (1.6)
A	dUTPase	e3ehwA1	A: beta barrels	X: beta-clip	H: dUTPase-like (From Topology)	T: dUTPase-like	F: dUTPase	ECOD (1.6)
C	dUTPase	e3ehwC1	A: beta barrels	X: beta-clip	H: dUTPase-like (From Topology)	T: dUTPase-like	F: dUTPase	ECOD (1.6)
D [auth X]	dUTPase	e3ehwX1	A: beta barrels	X: beta-clip	H: dUTPase-like (From Topology)	T: dUTPase-like	F: dUTPase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.70.40.10	Mainly Beta	Distorted Sandwich	Deoxyuridine 5'-Triphosphate Nucleotidohydrolase	Chain A	CATH (4.3.0)
E [auth Y]	2.70.40.10	Mainly Beta	Distorted Sandwich	Deoxyuridine 5'-Triphosphate Nucleotidohydrolase	Chain A	CATH (4.3.0)
F [auth Z]	2.70.40.10	Mainly Beta	Distorted Sandwich	Deoxyuridine 5'-Triphosphate Nucleotidohydrolase	Chain A	CATH (4.3.0)
A	2.70.40.10	Mainly Beta	Distorted Sandwich	Deoxyuridine 5'-Triphosphate Nucleotidohydrolase	Chain A	CATH (4.3.0)
C	2.70.40.10	Mainly Beta	Distorted Sandwich	Deoxyuridine 5'-Triphosphate Nucleotidohydrolase	Chain A	CATH (4.3.0)
D [auth X]	2.70.40.10	Mainly Beta	Distorted Sandwich	Deoxyuridine 5'-Triphosphate Nucleotidohydrolase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	PF00692	dUTPase (dUTPase)	dUTPase	dUTPase hydrolyses dUTP to dUMP and pyrophosphate.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	dUTP pyrophosphatase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding pyrophosphatase activity nucleoside triphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides dUTP diphosphatase activity hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity RNA binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding pyrophosphatase activity nucleoside triphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides dUTP diphosphatase activity hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity RNA binding organic cyclic compound binding nucleic acid binding	nucleobase-containing compound metabolic process DNA replication metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process pyrimidine deoxyribonucleotide metabolic process deoxyribose phosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process pyrimidine deoxyribonucleoside monophosphate metabolic process deoxyribonucleotide biosynthetic process nucleobase-containing compound metabolic process DNA replication metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process pyrimidine deoxyribonucleotide metabolic process deoxyribose phosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process pyrimidine deoxyribonucleoside monophosphate metabolic process deoxyribonucleotide biosynthetic process pyrimidine deoxyribonucleotide biosynthetic process deoxyribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process deoxyribonucleoside monophosphate biosynthetic process small molecule metabolic process pyrimidine-containing compound biosynthetic process pyrimidine deoxyribonucleoside monophosphate biosynthetic process phosphorus metabolic process nucleoside monophosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process pyrimidine nucleoside monophosphate metabolic process pyrimidine-containing compound metabolic process cellular metabolic process 2'-deoxyribonucleotide metabolic process 2'-deoxyribonucleotide biosynthetic process nucleotide metabolic process deoxyribose phosphate metabolic process nucleobase-containing compound biosynthetic process dUMP biosynthetic process nucleoside monophosphate biosynthetic process deoxyribonucleoside monophosphate metabolic process dUMP metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process cellular process pyrimidine nucleoside monophosphate biosynthetic process pyrimidine nucleotide biosynthetic process dTMP metabolic process dTMP biosynthetic process pyrimidine deoxyribonucleotide catabolic process catabolic process deoxyribonucleotide catabolic process nucleoside triphosphate catabolic process pyrimidine-containing compound catabolic process dUTP metabolic process organophosphate catabolic process pyrimidine nucleoside triphosphate catabolic process nucleoside phosphate catabolic process deoxyribose phosphate catabolic process pyrimidine nucleotide catabolic process pyrimidine deoxyribonucleoside triphosphate metabolic process dUTP catabolic process nucleotide catabolic process pyrimidine deoxyribonucleoside triphosphate catabolic process carbohydrate derivative catabolic process pyrimidine nucleoside triphosphate metabolic process nucleobase-containing compound catabolic process nucleoside triphosphate metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	IPR008181	Deoxyuridine triphosphate nucleotidohydrolase	Family
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	IPR033704	dUTPase, trimeric	Domain
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	IPR036157	dUTPase-like superfamily	Homologous Superfamily
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	IPR029054	dUTPase-like	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D [auth X], E [auth Y], A, B, C, D [auth X], E [auth Y], F [auth Z]	Pharos: P33316	gastric carcinoma malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma thoracic aortic aneurysm lung cancer medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm tuberculosis lymphoplasmacytic lymphoma nasopharyngeal carcinoma pancreatic ductal adenocarcinoma plasma cell myeloma ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.