Annotations: 3ER5

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth E]	d3er5e_	All beta proteins	Acid proteases	Acid proteases	Pepsin-like	Endothiapepsin	(Cryphonectria parasitica ) [TaxId: 5116 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth E]	SCOP2B Superfamily	Acid proteases	8033957	3001059	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth E]	Asp_C_1	e3er5E3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: Asp_C_1	ECOD (1.6)
A [auth E]	Asp_N	e3er5E2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: acid protease	F: Asp_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth E]	2.40.70.10	Mainly Beta	Beta Barrel	Cathepsin D, subunit A	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth E]	PF00026	Eukaryotic aspartyl protease (Asp)	Eukaryotic aspartyl protease	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E]	ENDOTHIAPEPSIN	aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity aspartic-type endopeptidase activity catalytic activity endopeptidase activity	proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	-
B [auth I]	H-189	enzyme regulator activity molecular function inhibitor activity peptidase regulator activity serine-type endopeptidase inhibitor activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity	regulated exocytosis transport secretion export from cell establishment of localization vesicle-mediated transport localization secretion by cell exocytosis cellular process calcium-ion regulated exocytosis sexual reproduction acrosome reaction reproductive process regulated exocytosis transport secretion export from cell establishment of localization vesicle-mediated transport localization secretion by cell exocytosis cellular process calcium-ion regulated exocytosis sexual reproduction acrosome reaction reproductive process fertilization single fertilization regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process regulation of systemic arterial blood pressure mediated by a chemical signal system process regulation of blood pressure biological regulation regulation of systemic arterial blood pressure circulatory system process endocrine process regulation of biological quality blood circulation regulation of epithelial to mesenchymal transition regulation of cellular process regulation of developmental process cellular developmental process positive regulation of biological process positive regulation of epithelial to mesenchymal transition regulation of cell differentiation mesenchyme development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development regulation of multicellular organismal process positive regulation of cellular process developmental process regulation of biological process animal organ development tissue development epithelial to mesenchymal transition positive regulation of multicellular organismal process mesenchymal cell differentiation regulation of tube diameter regulation of tube size vascular process in circulatory system blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death	cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth E]	IPR001461	Aspartic peptidase A1	Family
A [auth E]	IPR033121	Peptidase family A1 domain	Domain
A [auth E]	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
A [auth E]	IPR034163	Aspergillopepsin-like catalytic domain	Domain
A [auth E]	IPR001969	Aspartic peptidase, active site	Active Site
B [auth I]	IPR023795	Serpin, conserved site	Conserved Site
B [auth I]	IPR000227	Angiotensinogen	Family
B [auth I]	IPR000215	Serpin family	Family
B [auth I]	IPR023796	Serpin domain	Domain
B [auth I]	IPR042178	Serpin superfamily, domain 1	Homologous Superfamily
B [auth I]	IPR042185	Serpin superfamily, domain 2	Homologous Superfamily
B [auth I]	IPR036186	Serpin superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.