3FRX

Crystal Structure of the Yeast Orthologue of RACK1, Asc1.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3frxa_	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	automated matches	automated matches	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d3frxb_	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	automated matches	automated matches	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d3frxc_	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	automated matches	automated matches	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
D	d3frxd_	All beta proteins	7-bladed beta-propeller	WD40 repeat-like	automated matches	automated matches	yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ANAPC4_WD40_2	e3frxA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_2	ECOD (1.6)
B	ANAPC4_WD40_2	e3frxB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_2	ECOD (1.6)
C	ANAPC4_WD40_2	e3frxC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_2	ECOD (1.6)
D	ANAPC4_WD40_2	e3frxD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: ANAPC4_WD40_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
B	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
C	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)
D	2.130.10.10	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Guanine nucleotide-binding protein subunit beta-like protein	translation regulator activity GTPase regulator activity enzyme regulator activity GDP-dissociation inhibitor activity nucleoside-triphosphatase regulator activity molecular function regulator activity protein binding binding G-protein alpha-subunit binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding kinase binding protein kinase C binding translation regulator activity GTPase regulator activity enzyme regulator activity GDP-dissociation inhibitor activity nucleoside-triphosphatase regulator activity molecular function regulator activity protein binding binding G-protein alpha-subunit binding ribonucleoprotein complex binding protein-containing complex binding ribosome binding kinase binding protein kinase C binding enzyme binding protein kinase binding	regulation of biological process regulation of cellular ketone metabolic process regulation of cellular process regulation of cellular amino acid metabolic process regulation of amine metabolic process cellular metabolic process biological regulation amino acid metabolic process primary metabolic process regulation of cellular metabolic process regulation of primary metabolic process amine metabolic process cellular ketone metabolic process regulation of small molecule metabolic process regulation of biological process regulation of cellular ketone metabolic process regulation of cellular process regulation of cellular amino acid metabolic process regulation of amine metabolic process cellular metabolic process biological regulation amino acid metabolic process primary metabolic process regulation of cellular metabolic process regulation of primary metabolic process amine metabolic process cellular ketone metabolic process regulation of small molecule metabolic process metabolic process small molecule metabolic process cellular process regulation of metabolic process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process post-transcriptional regulation of gene expression negative regulation of translation negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of protein metabolic process negative regulation of metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process nonfunctional rRNA decay catabolic process RNA metabolic process rRNA catabolic process nucleic acid metabolic process macromolecule catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process nucleic acid catabolic process rRNA metabolic process RNA catabolic process cellular component disassembly ribosome disassembly rescue of stalled ribosome cellular component organization organelle organization organelle disassembly translational elongation cellular component organization or biogenesis cellular response to stimulus hexose mediated signaling response to stimulus negative regulation of signaling signaling homeostatic process regulation of signal transduction negative regulation of cell communication cell communication regulation of glucose mediated signaling pathway response to monosaccharide response to carbohydrate carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus signal transduction regulation of signaling negative regulation of response to stimulus response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis negative regulation of signal transduction cellular response to oxygen-containing compound response to hexose sugar mediated signaling pathway negative regulation of glucose mediated signaling pathway glucose mediated signaling pathway cellular response to carbohydrate stimulus cellular response to chemical stimulus cellular homeostasis chemical homeostasis regulation of response to stimulus response to glucose response to chemical glucose homeostasis regulation of cell communication carbohydrate mediated signaling regulation of translational frameshifting regulation of translational elongation negative regulation of translational frameshifting translational frameshifting negative regulation of translational elongation proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process ribosome-associated ubiquitin-dependent protein catabolic process cytoplasmic translation positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of phosphate metabolic process positive regulation of metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation G protein-coupled receptor signaling pathway regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality mRNA catabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process positive regulation of RNA metabolic process mRNA destabilization regulation of mRNA catabolic process RNA destabilization regulation of catabolic process mRNA metabolic process positive regulation of catabolic process regulation of mRNA stability positive regulation of mRNA catabolic process regulation of RNA stability regulation of mRNA metabolic process maintenance of translational fidelity	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit intracellular organelle ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cytosolic small ribosomal subunit protein-containing complex small ribosomal subunit intracellular organelle ribosomal subunit cytosolic ribosome organelle ribonucleoprotein complex intracellular non-membrane-bounded organelle ribosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR019775	WD40 repeat, conserved site	Conserved Site
A, B, C, D	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A, B, C, D	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A, B, C, D	IPR045223	Small ribosomal subunit protein RACK1-like	Family
A, B, C, D	IPR001680	WD40 repeat	Repeat
A, B, C, D	IPR020472	G-protein beta WD-40 repeat	Repeat

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.