Crystal structure of the Fab fragment of anti-CD20 antibody Ofatumumab
External Resource: Annotation
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
B [auth H] | C1-set_1 | e3gizH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
B [auth H] | V-set_12 | e3gizH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_12 | ECOD (1.6) |
A [auth L] | C1-set_4 | e3gizL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_4 | ECOD (1.6) |
A [auth L] | V-set | e3gizL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set | ECOD (1.6) |
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
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B [auth H] | Human 2F2 neutralizing mAb, anti-CD20 | VH-CH1 | Homo sapiens (human) | IGHV3-9*01, IGHJ6*01, IGHJ6*02, IGHG1*01, IGHG1*02, IGHG1*04 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_KAPPA | IMGT (202443-0) |
A [auth L] | Human 2F2 neutralizing mAb, anti-CD20 | L-KAPPA | Homo sapiens (human) | IGKV3-11*01, IGKJ5*01, IGKC*01 | V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA | IG | FAB-GAMMA-1_KAPPA | IMGT (202443-0) |
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
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B [auth H] | Heavy Chain | IGHV3 | - | - | SAbDab (2024-11-01) |
A [auth L] | Light Chain | IGKV3 | Kappa | - | SAbDab (2024-11-01) |