Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyNPC1 N-terminal domain-like 8045540 4004525 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyFrizzled domain-like 8090917 3001950 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ANPC1_Ne3gkjA1 A: few secondary structure elementsX: Frizzled cysteine-rich domain-related (From Topology)H: Frizzled cysteine-rich domain-related (From Topology)T: Frizzled cysteine-rich domain-relatedF: NPC1_NECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF16414Niemann-Pick C1 N terminus (NPC1_N)Niemann-Pick C1 N terminusThis is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket [1-2].Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Niemann-Pick C1 protein