3HBB
Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | Thymidylat_synt | e3hbbB1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
B | DHFR_1 | e3hbbB2 | A: a/b three-layered sandwiches | X: Dihydrofolate reductases (From Topology) | H: Dihydrofolate reductases (From Topology) | T: Dihydrofolate reductases | F: DHFR_1 | ECOD (1.6) |
C | Thymidylat_synt | e3hbbC1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
C | DHFR_1 | e3hbbC2 | A: a/b three-layered sandwiches | X: Dihydrofolate reductases (From Topology) | H: Dihydrofolate reductases (From Topology) | T: Dihydrofolate reductases | F: DHFR_1 | ECOD (1.6) |
A | Thymidylat_synt | e3hbbA1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
A | DHFR_1 | e3hbbA2 | A: a/b three-layered sandwiches | X: Dihydrofolate reductases (From Topology) | H: Dihydrofolate reductases (From Topology) | T: Dihydrofolate reductases | F: DHFR_1 | ECOD (1.6) |
D | Thymidylat_synt | e3hbbD1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
D | DHFR_1 | e3hbbD2 | A: a/b three-layered sandwiches | X: Dihydrofolate reductases (From Topology) | H: Dihydrofolate reductases (From Topology) | T: Dihydrofolate reductases | F: DHFR_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 3.40.430.10 | Alpha Beta | 3-Layer(aba) Sandwich | Dihydrofolate Reductase, subunit A | Dihydrofolate Reductase, subunit A | CATH (4.3.0) |
B | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
C | 3.40.430.10 | Alpha Beta | 3-Layer(aba) Sandwich | Dihydrofolate Reductase, subunit A | Dihydrofolate Reductase, subunit A | CATH (4.3.0) |
C | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
A | 3.40.430.10 | Alpha Beta | 3-Layer(aba) Sandwich | Dihydrofolate Reductase, subunit A | Dihydrofolate Reductase, subunit A | CATH (4.3.0) |
A | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
D | 3.40.430.10 | Alpha Beta | 3-Layer(aba) Sandwich | Dihydrofolate Reductase, subunit A | Dihydrofolate Reductase, subunit A | CATH (4.3.0) |
D | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR017925 | Dihydrofolate reductase conserved site | Conserved Site | |
IPR036926 | Thymidylate synthase/dCMP hydroxymethylase superfamily | Homologous Superfamily | |
IPR012262 | Bifunctional dihydrofolate reductase/thymidylate synthase | Family | |
IPR000398 | Thymidylate synthase | Family | |
IPR024072 | Dihydrofolate reductase-like domain superfamily | Homologous Superfamily | |
IPR001796 | Dihydrofolate reductase domain | Domain | |
IPR045097 | Thymidylate synthase/dCMP hydroxymethylase | Family | |
IPR020940 | Thymidylate synthase, active site | Active Site | |
IPR023451 | Thymidylate synthase/dCMP hydroxymethylase domain | Domain |