3HD7

HELICAL EXTENSION OF THE NEURONAL SNARE COMPLEX INTO THE MEMBRANE, spacegroup C 1 2 1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	SNARE fusion complex	8043664	3001549	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	SNARE fusion complex	8043664	3001549	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SNARE fusion complex	8043665	3001549	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	SNARE fusion complex	8043665	3001549	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	SNARE fusion complex	8043667	3001549	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	SNARE fusion complex	8043667	3001549	SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
E	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
F	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
G	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
D	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
H	1.20.5.110	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, E	PF00957	Synaptobrevin (Synaptobrevin)	Synaptobrevin	-	Family
B, F	PF05739	SNARE domain (SNARE)	SNARE domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, E	Vesicle-associated membrane protein 2	protein binding binding SNARE binding syntaxin binding phospholipid binding lipid binding SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding calmodulin binding identical protein binding syntaxin-1 binding transmembrane transporter binding protein binding binding SNARE binding syntaxin binding phospholipid binding lipid binding SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding calmodulin binding identical protein binding syntaxin-1 binding transmembrane transporter binding cytoskeletal protein binding myosin binding calcium-dependent protein binding	protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane localization within membrane protein localization to membrane establishment of localization vesicle-mediated transport to the plasma membrane protein transport macromolecule localization cellular process Golgi vesicle transport regulated exocytosis secretion export from cell secretion by cell exocytosis calcium-ion regulated exocytosis membrane organization protein-containing complex organization membrane fusion organelle membrane fusion cellular component organization cellular component biogenesis vesicle organization organelle fusion organelle organization cellular component assembly protein-containing complex assembly SNARE complex assembly cellular component organization or biogenesis vesicle fusion vesicle-mediated transport in synapse multicellular organismal process response to stimulus eosinophil activation cell activation involved in immune response leukocyte degranulation myeloid leukocyte mediated immunity myeloid leukocyte activation leukocyte activation establishment of localization in cell leukocyte activation involved in immune response eosinophil degranulation leukocyte mediated immunity eosinophil activation involved in immune response immune response cell activation myeloid cell activation involved in immune response immune effector process immune system process eosinophil mediated immunity granulocyte activation regulation of biological process signaling regulation of hormone levels biological regulation cell-cell signaling hormone secretion cell communication signal release hormone transport regulation of biological quality synaptic vesicle cycle synaptic vesicle exocytosis synaptic signaling trans-synaptic signaling neurotransmitter secretion neurotransmitter transport chemical synaptic transmission signal release from synapse anterograde trans-synaptic signaling regulation of localization regulation of cellular process regulation of protein localization positive regulation of biological process positive regulation of establishment of protein localization positive regulation of protein transport positive regulation of intracellular transport positive regulation of cellular process regulation of intracellular transport regulation of transport regulation of establishment of protein localization intracellular transport regulation of protein transport positive regulation of transport regulation of cellular localization positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport membrane docking organelle localization by membrane tethering organelle localization vesicle docking involved in exocytosis synaptic vesicle docking vesicle docking exocytic process synaptic vesicle endocytosis import into cell presynaptic endocytosis synaptic vesicle recycling endocytosis regulation of potassium ion transport monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of transmembrane transporter activity regulation of delayed rectifier potassium channel activity regulation of monoatomic ion transmembrane transport metal ion transport regulation of transporter activity monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of potassium ion transmembrane transporter activity regulation of monoatomic ion transmembrane transporter activity regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport regulation of cation channel activity inorganic cation transmembrane transport transmembrane transport regulation of molecular function regulation of transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport regulation of synaptic vesicle recycling response to hexose response to monosaccharide response to carbohydrate response to glucose response to chemical response to oxygen-containing compound regulation of vesicle-mediated transport regulation of secretion regulation of secretion by cell regulation of exocytosis cellular response to nitrogen compound cellular response to stimulus response to endogenous stimulus response to peptide hormone cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to insulin cellular response to insulin stimulus cellular response to hormone stimulus protein localization to synapse neurotransmitter receptor transport to postsynaptic membrane establishment of protein localization to postsynaptic membrane neurotransmitter receptor transport to plasma membrane protein localization to postsynaptic membrane neurotransmitter receptor transport exocytic insertion of neurotransmitter receptor to postsynaptic membrane protein-containing complex localization regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to postsynapse protein localization to cell junction receptor localization to synapse positive regulation of cell communication modulation of chemical synaptic transmission long-term synaptic potentiation regulation of synaptic plasticity regulation of signaling positive regulation of synaptic transmission regulation of trans-synaptic signaling regulation of cell communication positive regulation of signaling	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle synapse cell junction glutamatergic synapse Golgi apparatus subcompartment Golgi apparatus organelle subcompartment trans-Golgi network SNARE complex protein-containing complex synaptobrevin 2-SNAP-25-syntaxin-1a complex membrane protein complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex storage vacuole vacuole perinuclear region of cytoplasm zymogen granule zymogen granule membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane secretory granule membrane transport vesicle membrane presynapse synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane exocytic vesicle synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex axon neuron projection axon terminus plasma membrane bounded cell projection cell projection distal axon terminal bouton neuron projection terminus clathrin-coated vesicle coated vesicle cell periphery plasma membrane postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse cytosolic region postsynaptic cytosol cytosol
B, F	Syntaxin-1A	molecular function inhibitor activity chloride channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity transporter regulator activity channel inhibitor activity chloride channel regulator activity SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding molecular function inhibitor activity chloride channel inhibitor activity channel regulator activity transporter inhibitor activity ion channel regulator activity ion channel inhibitor activity molecular function regulator activity transporter regulator activity channel inhibitor activity chloride channel regulator activity SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding binding calcium channel inhibitor activity calcium channel regulator activity identical protein binding protein binding myosin heavy chain binding cytoskeletal protein binding myosin head/neck binding myosin binding ATP-dependent protein binding kinase binding enzyme binding transmembrane transporter binding SNARE binding calcium-dependent protein binding	localization transport neurotransmitter transport establishment of localization cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process response to stimulus signaling modulation of chemical synaptic transmission regulation of system process regulation of signal transduction localization transport neurotransmitter transport establishment of localization cellular response to stimulus multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process response to stimulus signaling modulation of chemical synaptic transmission regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication cellular process excitatory postsynaptic potential regulation of membrane potential positive regulation of cell communication positive regulation of signal transduction positive regulation of excitatory postsynaptic potential positive regulation of biological process positive regulation of response to stimulus positive regulation of cellular process positive regulation of signaling regulated exocytosis secretion export from cell vesicle-mediated transport secretion by cell exocytosis calcium-ion regulated exocytosis membrane organization protein-containing complex organization membrane fusion organelle membrane fusion cellular component organization cellular component biogenesis vesicle organization organelle fusion organelle organization cellular component assembly protein-containing complex assembly SNARE complex assembly cellular component organization or biogenesis vesicle fusion peptidyl-lysine modification primary metabolic process protein sumoylation macromolecule modification peptidyl-amino acid modification metabolic process protein metabolic process macromolecule metabolic process protein modification process post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal monoamine transport regulation of localization nitrogen compound transport regulation of catecholamine secretion organic hydroxy compound transport positive regulation of secretion by cell positive regulation of amine transport regulation of secretion by cell catecholamine transport positive regulation of secretion regulation of transport positive regulation of catecholamine secretion regulation of secretion catecholamine secretion amine transport positive regulation of transport regulation of amine transport regulation of calcium ion-dependent exocytosis positive regulation of exocytosis regulation of regulated secretory pathway positive regulation of regulated secretory pathway positive regulation of calcium ion-dependent exocytosis regulation of vesicle-mediated transport regulation of exocytosis protein localization cellular localization cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane regulation of hormone levels hormone secretion signal release hormone transport regulation of cellular component organization synaptic vesicle priming regulation of synaptic vesicle priming synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse regulation of protein-containing complex assembly establishment of localization in cell neurotransmitter secretion regulation of cellular component biogenesis signal release from synapse exocytic process response to abiotic stimulus response to gravity establishment of protein localization protein localization to extracellular region peptide secretion amide transport establishment of protein localization to extracellular region protein secretion peptide transport protein transport peptide hormone secretion insulin secretion organelle localization by membrane tethering organelle localization vesicle docking membrane docking vesicle docking involved in exocytosis synaptic vesicle docking synaptic vesicle endocytosis import into cell presynaptic endocytosis synaptic vesicle recycling endocytosis intracellular transport intracellular protein transport positive regulation of neurotransmitter secretion positive regulation of neurotransmitter transport regulation of neurotransmitter transport positive regulation of synaptic transmission regulation of neurotransmitter secretion endomembrane system organization vesicle fusion to plasma membrane synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle membrane organization norepinephrine transport positive regulation of norepinephrine secretion organic cation transport norepinephrine secretion regulation of norepinephrine secretion	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse cellular anatomical structure neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope nuclear envelope organelle membrane cytoskeleton membraneless organelle intracellular membraneless organelle actin cytoskeleton actomyosin presynapse presynaptic membrane intracellular vesicle cytoplasmic vesicle secretory granule secretory vesicle cytoplasm vesicle glutamatergic synapse cell projection neuron projection plasma membrane bounded cell projection SNARE complex protein-containing complex synaptobrevin 2-SNAP-25-syntaxin-1a complex membrane protein complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex transport vesicle membrane bounding membrane of organelle vesicle membrane synaptic vesicle synaptic vesicle membrane transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane exocytic vesicle axon synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex acrosomal vesicle presynaptic active zone membrane presynaptic active zone Schaffer collateral - CA1 synapse
C, G	Synaptosomal-associated protein 25	SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity protein binding binding protein domain specific binding syntaxin-1 binding SNARE binding syntaxin binding transmembrane transporter binding lipid binding cytoskeletal protein binding myosin binding calcium-dependent protein binding	positive regulation of cell communication regulation of localization regulation of cellular process regulation of hormone secretion signaling transport positive regulation of biological process positive regulation of secretion by cell hormone secretion cell communication localization positive regulation of hormone secretion regulation of secretion by cell secretion by cell positive regulation of secretion positive regulation of cell communication regulation of localization regulation of cellular process regulation of hormone secretion signaling transport positive regulation of biological process positive regulation of secretion by cell hormone secretion cell communication localization positive regulation of hormone secretion regulation of secretion by cell secretion by cell positive regulation of secretion signal release regulation of biological quality positive regulation of cellular process regulation of signaling regulation of biological process regulation of transport secretion regulation of hormone levels biological regulation export from cell cell-cell signaling establishment of localization regulation of secretion positive regulation of transport regulation of cell communication hormone transport cellular process positive regulation of signaling protein localization establishment of protein localization cellular localization regulation of protein localization regulation of establishment of protein localization regulation of cellular localization cellular macromolecule localization macromolecule localization membrane organization protein-containing complex organization membrane fusion organelle membrane fusion vesicle-mediated transport cellular component organization cellular component biogenesis vesicle organization organelle fusion organelle organization cellular component assembly protein-containing complex assembly SNARE complex assembly cellular component organization or biogenesis vesicle fusion multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development establishment of localization in cell intracellular transport endosomal transport regulated exocytosis synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse synaptic signaling calcium-ion regulated exocytosis calcium ion-regulated exocytosis of neurotransmitter trans-synaptic signaling neurotransmitter secretion neurotransmitter transport chemical synaptic transmission signal release from synapse exocytosis anterograde trans-synaptic signaling regulation of cellular component organization cell junction assembly regulation of synapse structure or activity regulation of synapse assembly synapse organization regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization cell junction organization synapse assembly establishment of organelle localization dense core granule localization organelle localization presynaptic dense core vesicle exocytosis secretory granule localization vesicle localization establishment of vesicle localization neuronal dense core vesicle exocytosis dense core granule exocytosis synaptic vesicle priming exocytic process behavior locomotory behavior system process learning or memory long-term memory nervous system process cognition memory learning associative learning import into cell receptor internalization protein-containing complex localization neurotransmitter receptor internalization receptor-mediated endocytosis endocytosis endomembrane system organization vesicle fusion to plasma membrane synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle membrane organization nitrogen compound transport positive regulation of establishment of protein localization positive regulation of insulin secretion regulation of peptide hormone secretion positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion regulation of protein secretion positive regulation of protein localization regulation of peptide secretion protein localization to extracellular region positive regulation of protein transport peptide secretion amide transport positive regulation of peptide secretion regulation of peptide transport regulation of protein transport positive regulation of protein secretion peptide transport protein transport regulation of insulin secretion peptide hormone secretion insulin secretion protein localization to synapse neurotransmitter receptor transport to postsynaptic membrane establishment of protein localization to postsynaptic membrane neurotransmitter receptor transport to plasma membrane protein localization to cell periphery protein localization to postsynaptic membrane neurotransmitter receptor transport establishment of protein localization to membrane localization within membrane protein localization to membrane exocytic insertion of neurotransmitter receptor to postsynaptic membrane vesicle-mediated transport to the plasma membrane regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to postsynapse protein localization to cell junction receptor localization to synapse regulation of neuron projection development regulation of cell projection organization regulation of plasma membrane bounded cell projection organization modulation of chemical synaptic transmission long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of trans-synaptic signaling	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium membrane photoreceptor inner segment intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium membrane photoreceptor inner segment intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cell periphery presynapse synapse cell junction plasma membrane presynaptic membrane plasma membrane region synaptic membrane cytoplasm glutamatergic synapse neuron projection membrane-bounded organelle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system trans-Golgi network SNARE complex protein-containing complex synaptobrevin 2-SNAP-25-syntaxin-1a complex membrane protein complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex perinuclear region of cytoplasm somatodendritic compartment cell body neuronal cell body axon synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex postsynapse transport vesicle intracellular vesicle cytoplasmic vesicle synaptic vesicle secretory vesicle vesicle exocytic vesicle actin-based cell projection filopodium growth cone distal axon axonal growth cone site of polarized growth cell cortex axon terminus terminal bouton neuron projection terminus ribbon synapse voltage-gated potassium channel complex plasma membrane protein complex potassium channel complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex presynaptic active zone membrane presynaptic active zone endosome extrinsic component of plasma membrane extrinsic component of synaptic membrane extrinsic component of presynaptic membrane extrinsic component of membrane BLOC complex intracellular protein-containing complex BLOC-1 complex
D, H	Synaptosomal-associated protein 25	SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity SNAP receptor activity protein-macromolecule adaptor activity molecular adaptor activity monoatomic cation transmembrane transporter activity gated channel activity monoatomic ion channel activity potassium ion transmembrane transporter activity voltage-gated channel activity voltage-gated monoatomic ion channel activity potassium channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity voltage-gated potassium channel activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity protein binding binding protein domain specific binding syntaxin-1 binding SNARE binding syntaxin binding transmembrane transporter binding lipid binding cytoskeletal protein binding myosin binding calcium-dependent protein binding	positive regulation of cell communication regulation of localization regulation of cellular process regulation of hormone secretion signaling transport positive regulation of biological process positive regulation of secretion by cell hormone secretion cell communication localization positive regulation of hormone secretion regulation of secretion by cell secretion by cell positive regulation of secretion positive regulation of cell communication regulation of localization regulation of cellular process regulation of hormone secretion signaling transport positive regulation of biological process positive regulation of secretion by cell hormone secretion cell communication localization positive regulation of hormone secretion regulation of secretion by cell secretion by cell positive regulation of secretion signal release regulation of biological quality positive regulation of cellular process regulation of signaling regulation of biological process regulation of transport secretion regulation of hormone levels biological regulation export from cell cell-cell signaling establishment of localization regulation of secretion positive regulation of transport regulation of cell communication hormone transport cellular process positive regulation of signaling protein localization establishment of protein localization cellular localization regulation of protein localization regulation of establishment of protein localization regulation of cellular localization cellular macromolecule localization macromolecule localization membrane organization protein-containing complex organization membrane fusion organelle membrane fusion vesicle-mediated transport cellular component organization cellular component biogenesis vesicle organization organelle fusion organelle organization cellular component assembly protein-containing complex assembly SNARE complex assembly cellular component organization or biogenesis vesicle fusion multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development establishment of localization in cell intracellular transport endosomal transport regulated exocytosis synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport in synapse synaptic signaling calcium-ion regulated exocytosis calcium ion-regulated exocytosis of neurotransmitter trans-synaptic signaling neurotransmitter secretion neurotransmitter transport chemical synaptic transmission signal release from synapse exocytosis anterograde trans-synaptic signaling regulation of cellular component organization cell junction assembly regulation of synapse structure or activity regulation of synapse assembly synapse organization regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization cell junction organization synapse assembly establishment of organelle localization dense core granule localization organelle localization presynaptic dense core vesicle exocytosis secretory granule localization vesicle localization establishment of vesicle localization neuronal dense core vesicle exocytosis dense core granule exocytosis synaptic vesicle priming exocytic process behavior locomotory behavior system process learning or memory long-term memory nervous system process cognition memory learning associative learning import into cell receptor internalization protein-containing complex localization neurotransmitter receptor internalization receptor-mediated endocytosis endocytosis endomembrane system organization vesicle fusion to plasma membrane synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle membrane organization nitrogen compound transport positive regulation of establishment of protein localization positive regulation of insulin secretion regulation of peptide hormone secretion positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion regulation of protein secretion positive regulation of protein localization regulation of peptide secretion protein localization to extracellular region positive regulation of protein transport peptide secretion amide transport positive regulation of peptide secretion regulation of peptide transport regulation of protein transport positive regulation of protein secretion peptide transport protein transport regulation of insulin secretion peptide hormone secretion insulin secretion protein localization to synapse neurotransmitter receptor transport to postsynaptic membrane establishment of protein localization to postsynaptic membrane neurotransmitter receptor transport to plasma membrane protein localization to cell periphery protein localization to postsynaptic membrane neurotransmitter receptor transport establishment of protein localization to membrane localization within membrane protein localization to membrane exocytic insertion of neurotransmitter receptor to postsynaptic membrane vesicle-mediated transport to the plasma membrane regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to postsynapse protein localization to cell junction receptor localization to synapse regulation of neuron projection development regulation of cell projection organization regulation of plasma membrane bounded cell projection organization modulation of chemical synaptic transmission long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of trans-synaptic signaling	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium membrane photoreceptor inner segment intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium membrane photoreceptor inner segment intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cell periphery presynapse synapse cell junction plasma membrane presynaptic membrane plasma membrane region synaptic membrane cytoplasm glutamatergic synapse neuron projection membrane-bounded organelle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system trans-Golgi network SNARE complex protein-containing complex synaptobrevin 2-SNAP-25-syntaxin-1a complex membrane protein complex synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex perinuclear region of cytoplasm somatodendritic compartment cell body neuronal cell body axon synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex postsynapse transport vesicle intracellular vesicle cytoplasmic vesicle synaptic vesicle secretory vesicle vesicle exocytic vesicle actin-based cell projection filopodium growth cone distal axon axonal growth cone site of polarized growth cell cortex axon terminus terminal bouton neuron projection terminus ribbon synapse voltage-gated potassium channel complex plasma membrane protein complex potassium channel complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex presynaptic active zone membrane presynaptic active zone endosome extrinsic component of plasma membrane extrinsic component of synaptic membrane extrinsic component of presynaptic membrane extrinsic component of membrane BLOC complex intracellular protein-containing complex BLOC-1 complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, E	IPR016444	Synaptobrevin/Vesicle-associated membrane protein	Family
A, E	IPR042855	v-SNARE, coiled-coil homology domain	Domain
A, E	IPR001388	Synaptobrevin-like	Family
B, F	IPR000727	Target SNARE coiled-coil homology domain	Domain
B, F	IPR006012	Syntaxin/epimorphin, conserved site	Conserved Site
B, F	IPR010989	SNARE	Homologous Superfamily
B, F	IPR006011	Syntaxin, N-terminal domain	Domain
B, F	IPR045242	Syntaxin	Family
C, G	IPR000727	Target SNARE coiled-coil homology domain	Domain
C, G	IPR039077	SNAP25, N-terminal SNARE motif, chordates	Domain
C, G	IPR000928	SNAP-25 domain	Domain
D, H	IPR000727	Target SNARE coiled-coil homology domain	Domain
D, H	IPR039077	SNAP25, N-terminal SNARE motif, chordates	Domain
D, H	IPR000928	SNAP-25 domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H	OPM				SNARE complex

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G, H	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C, D, E A, B, C, D, E, F, G, H	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	SNARE Protein Family	Syntaxin 1A/SNAP-25/Synaptobrevin-2 Complex with transmembrane regions

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.