3HSR

Crystal structure of Staphylococcus aureus protein SarZ in mixed disulfide form

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3hsra1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	(Staphylococcus aureus subsp. aureus str. Newman ) [TaxId: 426430 ],	SCOPe (2.08)
A	d3hsra2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Staphylococcus aureus subsp. aureus str. Newman ) [TaxId: 426430 ],	SCOPe (2.08)
B	d3hsrb1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	(Staphylococcus aureus subsp. aureus str. Newman ) [TaxId: 426430 ],	SCOPe (2.08)
B	d3hsrb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Staphylococcus aureus subsp. aureus str. Newman ) [TaxId: 426430 ],	SCOPe (2.08)
C	d3hsrc1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	(Staphylococcus aureus subsp. aureus str. Newman ) [TaxId: 426430 ],	SCOPe (2.08)
C	d3hsrc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Staphylococcus aureus subsp. aureus str. Newman ) [TaxId: 426430 ],	SCOPe (2.08)
D	d3hsrd1	All alpha proteins	DNA/RNA-binding 3-helical bundle	'Winged helix' DNA-binding domain	automated matches	automated matches	(Staphylococcus aureus subsp. aureus str. Newman ) [TaxId: 426430 ],	SCOPe (2.08)
D	d3hsrd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Staphylococcus aureus subsp. aureus str. Newman ) [TaxId: 426430 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MarR	e3hsrA1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: MarR	ECOD (1.6)
B	MarR	e3hsrB1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: MarR	ECOD (1.6)
C	MarR	e3hsrC1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: MarR	ECOD (1.6)
D	MarR	e3hsrD1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: MarR	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
B	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
C	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
D	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF22381	Transcriptional regulator SarA/Rot (Staph_reg_Sar_Rot)	Transcriptional regulator SarA/Rot	This entry represents transcriptional regulatory proteins in Staphylococcal species including SarA and Rot [1-5]. Sar is a global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm form ...	This entry represents transcriptional regulatory proteins in Staphylococcal species including SarA and Rot [1-5]. Sar is a global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm formation process in a cell density-dependent manner. Rot plays a key role in regulating S. aureus virulence through activation or repression of promoters that control expression of a large number of critical virulence factors [5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	HTH-type transcriptional regulator sarZ	transcription regulator activity DNA-binding transcription factor activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR000835	MarR-type HTH domain	Domain
A, B, C, D	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.