3K3A

Crystal Structure of B/Perth Neuraminidase D197E mutant in complex with Oseltamivir

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3k3aa_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
D	d3k3ad_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
E	d3k3ae_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
H	d3k3ah_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
J	d3k3aj_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
L	d3k3al_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
B	d3k3ab_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
C	d3k3ac_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
F	d3k3af_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
G	d3k3ag_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
I	d3k3ai_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
K	d3k3ak_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
M	d3k3am_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
N	d3k3an_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
O	d3k3ao_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
P	d3k3ap_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Neur	e3k3aA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
D	Neur	e3k3aD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
E	Neur	e3k3aE1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
H	Neur	e3k3aH1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
J	Neur	e3k3aJ1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
L	Neur	e3k3aL1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
B	Neur	e3k3aB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
C	Neur	e3k3aC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
F	Neur	e3k3aF1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
G	Neur	e3k3aG1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
I	Neur	e3k3aI1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
K	Neur	e3k3aK1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
M	Neur	e3k3aM1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
N	Neur	e3k3aN1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
O	Neur	e3k3aO1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)
P	Neur	e3k3aP1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: Neur	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
D	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
E	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
H	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
J	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
L	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
B	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
C	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
F	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
G	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
I	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
K	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
M	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
N	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
O	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
P	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	PF00064	Neuraminidase (Neur)	Neuraminidase	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	Neuraminidase	cation binding ion binding binding metal ion binding small molecule binding	carbohydrate metabolic process primary metabolic process metabolic process cellular process	cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane virion component virion membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR001860	Glycoside hydrolase, family 34	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR036278	Sialidase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.