Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFlu_PB2_6the3kc6A2 A: alpha arraysX: PB2 '627' domain-related (From Homology)H: PB2 '627' domain-relatedT: Polymerase basic protein 2 (PB2) '627' domainF: Flu_PB2_6thECOD (1.6)
AFlu_PB2_7the3kc6A1 A: a+b two layersX: PB2 C-terminal domain-like (From Topology)H: PB2 C-terminal domain-like (From Topology)T: PB2 C-terminal domain-likeF: Flu_PB2_7thECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.30.90 Alpha Beta 2-Layer Sandwich Defensin A-like Polymerase Basic Protein 2, C-terminal domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF20952Influenza RNA polymerase PB2 C-terminal domain (Flu_PB2_7th)Influenza RNA polymerase PB2 C-terminal domainInfluenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase ...Influenza virus encodes a large, multidomain RNA-dependent RNA polymerase that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site, whereas PB2 and PA/P3 contain, respectively, cap-binding [1] and endonuclease domains required for transcription initiation by cap-snatching [2]. This entry represents the C-terminal domain of Flu PB2 protein.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Polymerase PB2