Annotations: 3KE9

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LYTB_1st	e3ke9A1	A: a/b three-layered sandwiches	X: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase (From Topology)	H: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase (From Topology)	T: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase	F: LYTB_1st	ECOD (1.6)
A	LYTB_2nd	e3ke9A2	A: a/b three-layered sandwiches	X: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase (From Topology)	H: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase (From Topology)	T: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase	F: LYTB_2nd	ECOD (1.6)
A	LYTB_3rd	e3ke9A3	A: a/b three-layered sandwiches	X: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase (From Topology)	H: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase (From Topology)	T: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase	F: LYTB_3rd	ECOD (1.6)
B	LYTB_1st	e3ke9B1	A: a/b three-layered sandwiches	X: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase (From Topology)	H: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase (From Topology)	T: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase	F: LYTB_1st	ECOD (1.6)
B	LYTB_2nd	e3ke9B2	A: a/b three-layered sandwiches	X: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase (From Topology)	H: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase (From Topology)	T: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase	F: LYTB_2nd	ECOD (1.6)
B	LYTB_3rd	e3ke9B3	A: a/b three-layered sandwiches	X: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase (From Topology)	H: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase (From Topology)	T: NadA-like/4-hydroxy-3-methylbut-2-enyl diphosphate reductase	F: LYTB_3rd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.1010.20	Alpha Beta	3-Layer(aba) Sandwich	Cobalt-precorrin-4 Transmethylase	domain 1	CATH (4.3.0)
A	3.40.50.11270	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.40.1010.20	Alpha Beta	3-Layer(aba) Sandwich	Cobalt-precorrin-4 Transmethylase	domain 1	CATH (4.3.0)
B	3.40.50.11270	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02401	LytB protein (LYTB)	LytB protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	iron-sulfur cluster binding binding 3 iron, 4 sulfur cluster binding metal cluster binding small molecule binding oxidoreductase activity hydroxymethylbutenyl pyrophosphate reductase activity catalytic activity oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor oxidoreductase activity, acting on CH or CH2 groups 4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity 4 iron, 4 sulfur cluster binding cation binding ion binding iron-sulfur cluster binding binding 3 iron, 4 sulfur cluster binding metal cluster binding small molecule binding oxidoreductase activity hydroxymethylbutenyl pyrophosphate reductase activity catalytic activity oxidoreductase activity, acting on CH or CH2 groups, with an iron-sulfur protein as acceptor oxidoreductase activity, acting on CH or CH2 groups 4-hydroxy-3-methylbut-2-enyl diphosphate reductase activity 4 iron, 4 sulfur cluster binding cation binding ion binding metal ion binding	cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process cellular aldehyde metabolic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process primary metabolic process phospholipid biosynthetic process cellular biosynthetic process isopentenyl diphosphate biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process phospholipid metabolic process cellular aldehyde metabolic process phosphate-containing compound metabolic process phosphorus metabolic process isoprenoid biosynthetic process isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway cellular metabolic process primary metabolic process phospholipid biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process cellular process lipid metabolic process isoprenoid metabolic process isopentenyl diphosphate metabolic process terpenoid biosynthetic process terpenoid metabolic process dimethylallyl diphosphate biosynthetic process dimethylallyl diphosphate metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR003451	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.