3MBE

TCR 21.30 in complex with MHC class II I-Ag7HEL(11-27)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
G [auth F]	d3mbef2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G [auth F]	d3mbef1	Alpha and beta proteins (a+b)	MHC antigen-recognition domain	MHC antigen-recognition domain	MHC antigen-recognition domain	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
G [auth F]	d3mbef3	Artifacts	Tags	Tags	Tags	C-terminal Tags	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E [auth D]	d3mbed2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
E [auth D]	d3mbed1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	MHC antigen-recognition domain	8034745	3000521	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054689	3000071	SCOP2B (2022-06-29)
F [auth E]	SCOP2B Superfamily	MHC antigen-recognition domain	8034745	3000521	SCOP2B (2022-06-29)
F [auth E]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054689	3000071	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	MHC antigen-recognition domain	8055622	3000521	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054729	3000071	SCOP2B (2022-06-29)
G [auth F]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054729	3000071	SCOP2B (2022-06-29)
G [auth F]	SCOP2B Superfamily	MHC antigen-recognition domain	8055622	3000521	SCOP2B (2022-06-29)
E [auth D]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054553	3000071	SCOP2B (2022-06-29)
J [auth H]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054553	3000071	SCOP2B (2022-06-29)
I [auth G]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054541	3000071	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054541	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	C1-set_2	e3mbeA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
F [auth E]	C1-set_2	e3mbeE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_2	ECOD (1.6)
E [auth D]	C1-set	e3mbeD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
E [auth D]	V-set_3	e3mbeD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
J [auth H]	C1-set	e3mbeH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
J [auth H]	V-set_3	e3mbeH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
I [auth G]	DUF1968	e3mbeG2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: DUF1968	ECOD (1.6)
I [auth G]	V-set_4	e3mbeG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
D [auth C]	DUF1968	e3mbeC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: DUF1968	ECOD (1.6)
D [auth C]	V-set_4	e3mbeC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.320.10	Alpha Beta	Roll	Class II Histocompatibility Antigen, M Beta Chain	Chain B, domain 1	CATH (4.3.0)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
F [auth E]	3.10.320.10	Alpha Beta	Roll	Class II Histocompatibility Antigen, M Beta Chain	Chain B, domain 1	CATH (4.3.0)
F [auth E]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	3.10.320.10	Alpha Beta	Roll	Class II Histocompatibility Antigen, M Beta Chain	Chain B, domain 1	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
G [auth F]	3.10.320.10	Alpha Beta	Roll	Class II Histocompatibility Antigen, M Beta Chain	Chain B, domain 1	CATH (4.3.0)
G [auth F]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E [auth D]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
J [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
I [auth G]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, F [auth E]	MH2-AAd_MH2-AB-nod, peptide fused to N-terminus of G-BETA	II-ALPHA	Mus musculus (house mouse)	MH2-AAd	G-DOMAIN G-ALPHA, C-LIKE-DOMAIN C-LIKE	MH	MH2-ALPHA_PEPTIDE-BETA	IMGT (202444-0)
B, G [auth F]	MH2-AAd_MH2-AB-nod, peptide fused to N-terminus of G-BETA	PEPTIDE-II-BETA	Mus musculus (house mouse)	H2-AB-NOD	G-DOMAIN G-BETA, C-LIKE-DOMAIN C-LIKE	MH	MH2-ALPHA_PEPTIDE-BETA	IMGT (202444-0)
E [auth D], J [auth H]	TR 21.30	TR-BETA-1	Mus musculus (house mouse)	TRBV13-301, TRBJ1-301, TRBC101, TRBC201, TRBC2*03	V-DOMAIN V-BETA, C-DOMAIN C-BETA-1	TR	TR-ALPHA_BETA-1	IMGT (202444-0)
D [auth C], I [auth G]	TR 21.30	TR-ALPHA	Mus musculus (house mouse)	TRAV4-201, TRAJ3202, TRAC*01	V-DOMAIN V-ALPHA, C-DOMAIN C-ALPHA	TR	TR-ALPHA_BETA-1	IMGT (202444-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, F [auth E]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
A, F [auth E]	PF00993	Class II histocompatibility antigen, alpha domain (MHC_II_alpha)	Class II histocompatibility antigen, alpha domain	-	Domain
B, G [auth F]	PF00969	Class II histocompatibility antigen, beta domain (MHC_II_beta)	Class II histocompatibility antigen, beta domain	-	Domain
B, G [auth F]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
E [auth D], J [auth H]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain
D [auth C], I [auth G]	PF09291	Domain of unknown function (DUF1968) (DUF1968)	Domain of unknown function (DUF1968)	Members of this family are found in mammalian T-cell antigen receptor, and adopt an immunoglobulin-like beta-sandwich fold, with seven strands in two beta-sheets in a Greek-key topology. Their exact function has not, as yet, been determined.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, F [auth E]	MHC CLASS II H2-IAg7 ALPHA CHAIN	binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding	regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process adaptive immune response antigen processing and presentation of exogenous peptide antigen via MHC class II regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process adaptive immune response antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen antigen processing and presentation of exogenous antigen negative regulation of lymphocyte proliferation multicellular organismal process regulation of cellular process regulation of leukocyte activation negative regulation of biological process regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion negative regulation of cellular process regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of immune system process regulation of mononuclear cell proliferation cellular process regulation of lymphocyte activation peptide antigen assembly with MHC class II protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class II protein complex assembly cellular component organization cellular component biogenesis cellular component assembly protein-containing complex assembly MHC protein complex assembly cellular component organization or biogenesis positive regulation of leukocyte cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation positive regulation of leukocyte activation positive regulation of cellular process positive regulation of T cell activation positive regulation of cell adhesion positive regulation of multicellular organismal process regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of developmental process multicellular organism development cell differentiation anatomical structure development T cell differentiation developmental process positive regulation of cell development leukocyte differentiation cellular developmental process regulation of developmental process cell development regulation of T cell differentiation positive regulation of hemopoiesis positive regulation of cell differentiation regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane MHC protein complex MHC class II protein complex protein-containing complex plasma membrane protein complex membrane protein complex membrane-bounded organelle endosome membrane cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane MHC protein complex MHC class II protein complex protein-containing complex plasma membrane protein complex membrane protein complex membrane-bounded organelle endosome membrane intracellular anatomical structure endosome intracellular vesicle late endosome membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle late endosome cytoplasm vesicle organelle membrane lytic vacuole vacuole lysosome vacuolar membrane lytic vacuole membrane lysosomal membrane
B, G [auth F]	MHC CLASS II H2-IAg7 BETA CHAIN	-	response to stimulus immune response immune system process adaptive immune response antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation antigen processing and presentation of peptide or polysaccharide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class II antigen processing and presentation of exogenous peptide antigen antigen processing and presentation of peptide antigen antigen processing and presentation of exogenous antigen	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle Golgi apparatus membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle Golgi apparatus cell surface MHC protein complex cell periphery MHC class II protein complex protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex late endosome multivesicular body
E [auth D], J [auth H]	TCR 21.3 beta chain	-	-	protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity alpha-beta T cell receptor complex receptor complex cell periphery plasma membrane signaling receptor complex T cell receptor complex
C [auth P], H [auth Q]	PEPTIDE HEL 11-27	hydrolase activity, acting on glycosyl bonds hexosaminidase activity beta-N-acetylhexosaminidase activity beta-N-acetylglucosaminidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity peptidoglycan muralytic activity lysozyme activity identical protein binding protein binding binding	catabolic process cell wall organization or biogenesis metabolic process cellular process macromolecule metabolic process macromolecule catabolic process cell wall macromolecule catabolic process cell wall macromolecule metabolic process biological process involved in interspecies interaction between organisms disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing response to stimulus catabolic process cell wall organization or biogenesis metabolic process cellular process macromolecule metabolic process macromolecule catabolic process cell wall macromolecule catabolic process cell wall macromolecule metabolic process biological process involved in interspecies interaction between organisms disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing response to stimulus response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus defense response to Gram-positive bacterium	intracellular anatomical structure cytoplasm cellular anatomical entity extracellular region extracellular space membrane-bounded organelle intracellular organelle organelle endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system
D [auth C], I [auth G]	TCR 21.3 alpha chain	-	response to stimulus immune response immune system process adaptive immune response biological process involved in interspecies interaction between organisms response to other organism response to bacterium response to external stimulus response to external biotic stimulus response to biotic stimulus	cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex cellular anatomical entity T cell receptor complex receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, F [auth E]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, F [auth E]	IPR050160	Major Histocompatibility Complex/Immunoglobulin	Family
A, F [auth E]	IPR003597	Immunoglobulin C1-set	Domain
A, F [auth E]	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
A, F [auth E]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
A, F [auth E]	IPR014745	MHC class II, alpha/beta chain, N-terminal	Homologous Superfamily
A, F [auth E]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, F [auth E]	IPR007110	Immunoglobulin-like domain	Domain
A, F [auth E]	IPR001003	MHC class II, alpha chain, N-terminal	Domain
B, G [auth F]	IPR000353	MHC class II, beta chain, N-terminal	Domain
B, G [auth F]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B, G [auth F]	IPR050160	Major Histocompatibility Complex/Immunoglobulin	Family
B, G [auth F]	IPR014745	MHC class II, alpha/beta chain, N-terminal	Homologous Superfamily
B, G [auth F]	IPR003597	Immunoglobulin C1-set	Domain
B, G [auth F]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, G [auth F]	IPR011162	MHC classes I/II-like antigen recognition protein	Homologous Superfamily
B, G [auth F]	IPR007110	Immunoglobulin-like domain	Domain
B, G [auth F]	IPR003006	Immunoglobulin/major histocompatibility complex, conserved site	Conserved Site
E [auth D], J [auth H]	IPR003597	Immunoglobulin C1-set	Domain
E [auth D], J [auth H]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
E [auth D], J [auth H]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
E [auth D], J [auth H]	IPR007110	Immunoglobulin-like domain	Domain
E [auth D], J [auth H]	IPR050380	Immune Recognition and Response Modulators	Family
C [auth P], H [auth Q]	IPR001916	Glycoside hydrolase, family 22	Family
C [auth P], H [auth Q]	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily
C [auth P], H [auth Q]	IPR019799	Glycoside hydrolase family 22 domain	Domain
C [auth P], H [auth Q]	IPR000974	Glycoside hydrolase, family 22, lysozyme	Family
D [auth C], I [auth G]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
D [auth C], I [auth G]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
D [auth C], I [auth G]	IPR015370	T-cell receptor alpha chain, constant domain	Domain