3MMZ

CRYSTAL STRUCTURE OF putative HAD family hydrolase from Streptomyces avermitilis MA-4680

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3mmza1	Alpha and beta proteins (a/b)	HAD-like	HAD-like	automated matches	automated matches	(Streptomyces avermitilis MA-4680 = NBRC 14893 ) [TaxId: 227882 ],	SCOPe (2.08)
A	d3mmza2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Streptomyces avermitilis MA-4680 = NBRC 14893 ) [TaxId: 227882 ],	SCOPe (2.08)
B	d3mmzb1	Alpha and beta proteins (a/b)	HAD-like	HAD-like	automated matches	automated matches	(Streptomyces avermitilis MA-4680 = NBRC 14893 ) [TaxId: 227882 ],	SCOPe (2.08)
B	d3mmzb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Streptomyces avermitilis MA-4680 = NBRC 14893 ) [TaxId: 227882 ],	SCOPe (2.08)
C	d3mmzc1	Alpha and beta proteins (a/b)	HAD-like	HAD-like	automated matches	automated matches	(Streptomyces avermitilis MA-4680 = NBRC 14893 ) [TaxId: 227882 ],	SCOPe (2.08)
C	d3mmzc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Streptomyces avermitilis MA-4680 = NBRC 14893 ) [TaxId: 227882 ],	SCOPe (2.08)
D	d3mmzd1	Alpha and beta proteins (a/b)	HAD-like	HAD-like	automated matches	automated matches	(Streptomyces avermitilis MA-4680 = NBRC 14893 ) [TaxId: 227882 ],	SCOPe (2.08)
D	d3mmzd3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Streptomyces avermitilis MA-4680 = NBRC 14893 ) [TaxId: 227882 ],	SCOPe (2.08)
D	d3mmzd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Streptomyces avermitilis MA-4680 = NBRC 14893 ) [TaxId: 227882 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	HAD-like	8081292	3001890	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	HAD-like	8081292	3001890	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	HAD-like	8081292	3001890	SCOP2B (2022-06-29)
D	SCOP2 Family	Phosphatase YrbI-like	8081291	4003238	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	HAD-like	8081292	3001890	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hydrolase_3_1	e3mmzA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Hydrolase_3_1	ECOD (1.6)
B	Hydrolase_3_1	e3mmzB1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Hydrolase_3_1	ECOD (1.6)
C	Hydrolase_3_1	e3mmzC1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Hydrolase_3_1	ECOD (1.6)
D	Hydrolase_3_1	e3mmzD1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Hydrolase_3_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
B	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
C	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
D	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF08282	haloacid dehalogenase-like hydrolase (Hydrolase_3)	haloacid dehalogenase-like hydrolase	This family contains haloacid dehalogenase-like hydrolase enzymes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	putative HAD family hydrolase	N-acylneuraminate cytidylyltransferase activity cytidylyltransferase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups hydrolase activity, acting on ester bonds hydrolase activity cation binding ion binding binding metal ion binding small molecule binding	lipopolysaccharide biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process cellular biosynthetic process carbohydrate biosynthetic process cellular metabolic process liposaccharide metabolic process lipid biosynthetic process carbohydrate derivative metabolic process primary metabolic process macromolecule biosynthetic process lipopolysaccharide metabolic process polysaccharide metabolic process biosynthetic process lipopolysaccharide biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process cellular biosynthetic process carbohydrate biosynthetic process cellular metabolic process liposaccharide metabolic process lipid biosynthetic process carbohydrate derivative metabolic process primary metabolic process macromolecule biosynthetic process lipopolysaccharide metabolic process polysaccharide metabolic process biosynthetic process metabolic process cellular process macromolecule metabolic process lipid metabolic process oxoacid metabolic process carboxylic acid metabolic process organic acid metabolic process amino sugar metabolic process small molecule metabolic process amide metabolic process N-acetylneuraminate metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR050793	CMP-NeuNAc synthase	Family
A, B, C, D	IPR036412	HAD-like superfamily	Homologous Superfamily
A, B, C, D	IPR023214	HAD superfamily	Homologous Superfamily
A, B, C, D	IPR029044	Nucleotide-diphospho-sugar transferases	Homologous Superfamily
A, B, C, D	IPR003329	Acylneuraminate cytidylyltransferase	Family
A, B, C, D	IPR010023	KdsC family	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.