3N6Q

Crystal structure of YghZ from E. coli

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3n6qa_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	NAD(P)-linked oxidoreductase	automated matches	automated matches	(Escherichia coli DH5[alpha] ) [TaxId: 668369 ],	SCOPe (2.08)
B	d3n6qb_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	NAD(P)-linked oxidoreductase	automated matches	automated matches	(Escherichia coli DH5[alpha] ) [TaxId: 668369 ],	SCOPe (2.08)
D	d3n6qd_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	NAD(P)-linked oxidoreductase	automated matches	automated matches	(Escherichia coli DH5[alpha] ) [TaxId: 668369 ],	SCOPe (2.08)
E	d3n6qe_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	NAD(P)-linked oxidoreductase	automated matches	automated matches	(Escherichia coli DH5[alpha] ) [TaxId: 668369 ],	SCOPe (2.08)
F	d3n6qf_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	NAD(P)-linked oxidoreductase	automated matches	automated matches	(Escherichia coli DH5[alpha] ) [TaxId: 668369 ],	SCOPe (2.08)
H	d3n6qh_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	NAD(P)-linked oxidoreductase	automated matches	automated matches	(Escherichia coli DH5[alpha] ) [TaxId: 668369 ],	SCOPe (2.08)
C	d3n6qc_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	NAD(P)-linked oxidoreductase	automated matches	automated matches	(Escherichia coli DH5[alpha] ) [TaxId: 668369 ],	SCOPe (2.08)
G	d3n6qg_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	NAD(P)-linked oxidoreductase	automated matches	automated matches	(Escherichia coli DH5[alpha] ) [TaxId: 668369 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	NAD(P)-linked oxidoreductase	8062069	3000288	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	NAD(P)-linked oxidoreductase	8062069	3000288	SCOP2B (2022-06-29)
D	SCOP2 Family	Aldo-keto reductases (NADP)	8062068	4003124	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	NAD(P)-linked oxidoreductase	8062069	3000288	SCOP2 (2022-06-29)
E	SCOP2B Superfamily	NAD(P)-linked oxidoreductase	8062069	3000288	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	NAD(P)-linked oxidoreductase	8062069	3000288	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	NAD(P)-linked oxidoreductase	8062069	3000288	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	NAD(P)-linked oxidoreductase	8062069	3000288	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	NAD(P)-linked oxidoreductase	8062069	3000288	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aldo_ket_red	e3n6qA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
B	Aldo_ket_red	e3n6qB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
D	Aldo_ket_red	e3n6qD1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
E	Aldo_ket_red	e3n6qE1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
F	Aldo_ket_red	e3n6qF1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
H	Aldo_ket_red	e3n6qH1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
C	Aldo_ket_red	e3n6qC1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)
G	Aldo_ket_red	e3n6qG1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Aldo_ket_red	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.100	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	NADP-dependent oxidoreductase domain	CATH (4.3.0)
B	3.20.20.100	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	NADP-dependent oxidoreductase domain	CATH (4.3.0)
D	3.20.20.100	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	NADP-dependent oxidoreductase domain	CATH (4.3.0)
E	3.20.20.100	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	NADP-dependent oxidoreductase domain	CATH (4.3.0)
F	3.20.20.100	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	NADP-dependent oxidoreductase domain	CATH (4.3.0)
H	3.20.20.100	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	NADP-dependent oxidoreductase domain	CATH (4.3.0)
C	3.20.20.100	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	NADP-dependent oxidoreductase domain	CATH (4.3.0)
G	3.20.20.100	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	NADP-dependent oxidoreductase domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00248	Aldo/keto reductase family (Aldo_ket_red)	Aldo/keto reductase family	This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	YghZ aldo-keto reductase	oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors catalytic activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process catabolic process cellular metabolic process methylglyoxal catabolic process cellular catabolic process cellular ketone metabolic process cellular aldehyde metabolic process ketone catabolic process metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process catabolic process cellular metabolic process methylglyoxal catabolic process cellular catabolic process cellular ketone metabolic process cellular aldehyde metabolic process ketone catabolic process metabolic process small molecule metabolic process aldehyde catabolic process small molecule catabolic process methylglyoxal metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036812	NADP-dependent oxidoreductase domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR047628	L-glyceraldehyde 3-phosphate reductase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR023210	NADP-dependent oxidoreductase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR005399	Potassium channel, voltage-dependent, beta subunit, KCNAB-related	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.