3OZW

The Crystal Structure of flavohemoglobin from R. eutrophus in complex with ketoconazole

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3ozwa1	All alpha proteins	Globin-like	Globin-like	automated matches	automated matches	Cupriavidus necator (Cupriavidus necator H16 ) [TaxId: 381666 ],	SCOPe (2.08)
A	d3ozwa2	All beta proteins	Reductase/isomerase/elongation factor common domain	Riboflavin synthase domain-like	automated matches	automated matches	Cupriavidus necator (Cupriavidus necator H16 ) [TaxId: 381666 ],	SCOPe (2.08)
A	d3ozwa3	Alpha and beta proteins (a/b)	Ferredoxin reductase-like, C-terminal NADP-linked domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	automated matches	automated matches	Cupriavidus necator (Cupriavidus necator H16 ) [TaxId: 381666 ],	SCOPe (2.08)
B	d3ozwb1	All alpha proteins	Globin-like	Globin-like	automated matches	automated matches	Cupriavidus necator (Cupriavidus necator H16 ) [TaxId: 381666 ],	SCOPe (2.08)
B	d3ozwb2	All beta proteins	Reductase/isomerase/elongation factor common domain	Riboflavin synthase domain-like	automated matches	automated matches	Cupriavidus necator (Cupriavidus necator H16 ) [TaxId: 381666 ],	SCOPe (2.08)
B	d3ozwb3	Alpha and beta proteins (a/b)	Ferredoxin reductase-like, C-terminal NADP-linked domain	Ferredoxin reductase-like, C-terminal NADP-linked domain	automated matches	automated matches	Cupriavidus necator (Cupriavidus necator H16 ) [TaxId: 381666 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ferredoxin reductase-like, C-terminal NADP-linked domain	8044199	3001461	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Globin-like	8036253	3000554	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Riboflavin synthase domain-like	8042066	3001812	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Riboflavin synthase domain-like	8042066	3001812	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ferredoxin reductase-like, C-terminal NADP-linked domain	8044199	3001461	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Globin-like	8036253	3000554	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FAD_binding_6	e3ozwA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: FAD_binding_6	ECOD (1.6)
A	Globin	e3ozwA2	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
A	NAD_binding_1	e3ozwA3	A: a/b three-layered sandwiches	X: Ferredoxin reductase-like, C-terminal NADP-linked domain (From Topology)	H: Ferredoxin reductase-like, C-terminal NADP-linked domain (From Topology)	T: Ferredoxin reductase-like, C-terminal NADP-linked domain	F: NAD_binding_1	ECOD (1.6)
B	FAD_binding_6	e3ozwB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: FAD_binding_6	ECOD (1.6)
B	Globin	e3ozwB2	A: alpha arrays	X: Globin-like (From Topology)	H: Globin-like (From Topology)	T: Globin-like	F: Globin	ECOD (1.6)
B	NAD_binding_1	e3ozwB3	A: a/b three-layered sandwiches	X: Ferredoxin reductase-like, C-terminal NADP-linked domain (From Topology)	H: Ferredoxin reductase-like, C-terminal NADP-linked domain (From Topology)	T: Ferredoxin reductase-like, C-terminal NADP-linked domain	F: NAD_binding_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
A	2.40.30.10	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
A	3.40.50.80	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module	CATH (4.3.0)
B	1.10.490.10	Mainly Alpha	Orthogonal Bundle	Globin-like	Globins	CATH (4.3.0)
B	2.40.30.10	Mainly Beta	Beta Barrel	Elongation Factor Tu (Ef-tu)	domain 3	CATH (4.3.0)
B	3.40.50.80	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00042	Globin (Globin)	Globin	-	Domain
A, B	PF00175	Oxidoreductase NAD-binding domain (NAD_binding_1)	Oxidoreductase NAD-binding domain	Xanthine dehydrogenases, that also bind FAD/NAD, have essentially no similarity.	Domain
A, B	PF00970	Oxidoreductase FAD-binding domain (FAD_binding_6)	Oxidoreductase FAD-binding domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Flavohemoglobin	oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen nitric oxide dioxygenase NAD(P)H activity catalytic activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor dioxygenase activity oxygen binding binding small molecule binding oxygen carrier activity molecular carrier activity FAD binding flavin adenine dinucleotide binding nucleoside phosphate binding oxidoreductase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen nitric oxide dioxygenase NAD(P)H activity catalytic activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor dioxygenase activity oxygen binding binding small molecule binding oxygen carrier activity molecular carrier activity FAD binding flavin adenine dinucleotide binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding tetrapyrrole binding heme binding cation binding metal ion binding	nitric oxide metabolic process catabolic process nitric oxide catabolic process metabolic process reactive nitrogen species metabolic process response to stimulus response to chemical response to toxic substance cellular response to stimulus cellular response to chemical stimulus response to nitrosative stress cellular response to stress response to stress cellular process nitric oxide metabolic process catabolic process nitric oxide catabolic process metabolic process reactive nitrogen species metabolic process response to stimulus response to chemical response to toxic substance cellular response to stimulus cellular response to chemical stimulus response to nitrosative stress cellular response to stress response to stress cellular process cellular response to nitrosative stress cellular response to chemical stress	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001433	Oxidoreductase FAD/NAD(P)-binding	Domain
A, B	IPR023950	Flavohemoprotein	Family
A, B	IPR009050	Globin-like superfamily	Homologous Superfamily
A, B	IPR012292	Globin/Protoglobin	Homologous Superfamily
A, B	IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain	Homologous Superfamily
A, B	IPR008333	Flavoprotein pyridine nucleotide cytochrome reductase-like, FAD-binding domain	Domain
A, B	IPR017938	Riboflavin synthase-like beta-barrel	Homologous Superfamily
A, B	IPR017927	FAD-binding domain, ferredoxin reductase-type	Domain
A, B	IPR000971	Globin	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.