3P24

Structure of profragilysin-3 from Bacteroides fragilis

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	fragilysinNterm	e3p24A1	A: a+b two layers	X: Fragilysin-3 prodomain-like	H: Fragilysin-3 prodomain (From Topology)	T: Fragilysin-3 prodomain	F: fragilysinNterm	ECOD (1.6)
A	Reprolysin	e3p24A2	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Reprolysin	ECOD (1.6)
B	fragilysinNterm	e3p24B2	A: a+b two layers	X: Fragilysin-3 prodomain-like	H: Fragilysin-3 prodomain (From Topology)	T: Fragilysin-3 prodomain	F: fragilysinNterm	ECOD (1.6)
B	Reprolysin	e3p24B1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Reprolysin	ECOD (1.6)
C	fragilysinNterm	e3p24C2	A: a+b two layers	X: Fragilysin-3 prodomain-like	H: Fragilysin-3 prodomain (From Topology)	T: Fragilysin-3 prodomain	F: fragilysinNterm	ECOD (1.6)
C	Reprolysin	e3p24C1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Reprolysin	ECOD (1.6)
D	fragilysinNterm	e3p24D2	A: a+b two layers	X: Fragilysin-3 prodomain-like	H: Fragilysin-3 prodomain (From Topology)	T: Fragilysin-3 prodomain	F: fragilysinNterm	ECOD (1.6)
D	Reprolysin	e3p24D1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Reprolysin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.128.470	Mainly Beta	Beta Barrel	Lipocalin		CATH (4.3.0)
A	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)
B	2.40.128.470	Mainly Beta	Beta Barrel	Lipocalin		CATH (4.3.0)
B	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)
C	2.40.128.470	Mainly Beta	Beta Barrel	Lipocalin		CATH (4.3.0)
C	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)
D	2.40.128.470	Mainly Beta	Beta Barrel	Lipocalin		CATH (4.3.0)
D	3.40.390.10	Alpha Beta	3-Layer(aba) Sandwich	Collagenase (Catalytic Domain)	Collagenase (Catalytic Domain)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF16376	N-terminal domain of fragilysin (fragilysinNterm)	N-terminal domain of fragilysin	N-terminal domain of fragilysin, an extracellular metalloprotease toxin, which is primary virulence factor of B. fragilis, an oportunistic pathogen of human gut. The N-terminal domain of fragilysin inhibits fragilysin and is cleaved ...	N-terminal domain of fragilysin, an extracellular metalloprotease toxin, which is primary virulence factor of B. fragilis, an oportunistic pathogen of human gut. The N-terminal domain of fragilysin inhibits fragilysin and is cleaved in a mature, virulent form.	Domain
A, B, C, D	PF13583	Metallo-peptidase family M12B Reprolysin-like (Reprolysin_4)	Metallo-peptidase family M12B Reprolysin-like	This zinc-binding metallo-peptidase has the characteristic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	BFT-3	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding	proteolysis metabolic process primary metabolic process protein metabolic process macromolecule metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR038176	Fragilysin, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR006026	Peptidase, metallopeptidase	Domain
A, B, C, D	IPR024079	Metallopeptidase, catalytic domain superfamily	Homologous Superfamily
A, B, C, D	IPR032273	Fragilysin, N-terminal	Domain
A, B, C, D	IPR001843	Fragilysin	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.