3PBL

Structure of the human dopamine D3 receptor in complex with eticlopride

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Class A (rhodopsin) G protein-coupled receptor-like	8091205	4001858	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	G protein-coupled receptor-like	8091206	3000473	SCOP2 (2022-06-29)
A	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	G protein-coupled receptor-like	8091206	3000473	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	G protein-coupled receptor-like	8091206	3000473	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_1_2	e3pblA3	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_2	ECOD (1.6)
A	Phage_lysozyme_2	e3pblA4	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
B	7tm_1_2	e3pblB3	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_1_2	ECOD (1.6)
B	Phage_lysozyme_2	e3pblB4	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1070.10	Mainly Alpha	Up-down Bundle	Rhopdopsin 7-helix transmembrane proteins	Rhodopsin 7-helix transmembrane proteins	CATH (4.3.0)
A	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
B	1.20.1070.10	Mainly Alpha	Up-down Bundle	Rhopdopsin 7-helix transmembrane proteins	Rhodopsin 7-helix transmembrane proteins	CATH (4.3.0)
B	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain
A, B	PF00001	7 transmembrane receptor (rhodopsin family) (7tm_1)	7 transmembrane receptor (rhodopsin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	D(3) dopamine receptor, Lysozyme chimera	molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity neurotransmitter receptor activity dopamine neurotransmitter receptor activity postsynaptic neurotransmitter receptor activity dopamine neurotransmitter receptor activity, coupled via Gi/Go hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process cell development regulation of cell differentiation regulation of neurogenesis regulation of gliogenesis regulation of cell development regulation of nervous system development multicellular organism development neurogenesis negative regulation of neurogenesis gliogenesis multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process cell development regulation of cell differentiation regulation of neurogenesis regulation of gliogenesis regulation of cell development regulation of nervous system development multicellular organism development neurogenesis negative regulation of neurogenesis gliogenesis cell differentiation anatomical structure development negative regulation of cellular process regulation of multicellular organismal process negative regulation of nervous system development negative regulation of cell differentiation system development developmental process regulation of biological process regulation of multicellular organismal development negative regulation of developmental process regulation of glial cell differentiation biological regulation nervous system development negative regulation of gliogenesis negative regulation of cell development negative regulation of oligodendrocyte differentiation negative regulation of glial cell differentiation central nervous system development oligodendrocyte differentiation glial cell differentiation cellular process negative regulation of multicellular organismal process regulation of oligodendrocyte differentiation response to stimulus response to chemical response to xenobiotic stimulus negative regulation of protein transport protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport negative regulation of transport protein localization to extracellular region localization negative regulation of secretion regulation of secretion by cell secretion by cell cellular macromolecule localization negative regulation of secretion by cell negative regulation of protein localization regulation of transport secretion regulation of establishment of protein localization establishment of protein localization to extracellular region negative regulation of establishment of protein localization export from cell regulation of protein transport protein secretion establishment of localization regulation of secretion regulation of protein secretion negative regulation of protein secretion protein transport regulation of cellular localization macromolecule localization behavior locomotory behavior regulation of cytokinesis positive regulation of cell division regulation of cell cycle process positive regulation of biological process cytokinesis positive regulation of cell cycle regulation of cell division positive regulation of cytokinesis positive regulation of cell cycle process cell division cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process adult behavior response to oxygen-containing compound response to nitrogen compound response to alkaloid behavioral response to cocaine response to organic cyclic compound response to cocaine system process learning learning or memory nervous system process cognition monoamine transport signaling regulation of catecholamine secretion organic hydroxy compound transport dopamine transport cell communication catecholamine transport signal release cell-cell signaling dopamine secretion catecholamine secretion amine transport regulation of amine transport regulation of dopamine secretion import into cell regulation of catecholamine uptake involved in synaptic transmission catecholamine uptake dopamine uptake involved in synaptic transmission synaptic signaling establishment of localization in cell regulation of dopamine uptake involved in synaptic transmission neurotransmitter reuptake regulation of neurotransmitter uptake trans-synaptic signaling catecholamine uptake involved in synaptic transmission regulation of neurotransmitter transport neurotransmitter transport chemical synaptic transmission anterograde trans-synaptic signaling neurotransmitter uptake synaptic transmission, dopaminergic dopamine uptake inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis adenylate cyclase-inhibiting dopamine receptor signaling pathway cellular response to stimulus cellular response to nitrogen compound response to dopamine cellular response to dopamine response to monoamine response to catecholamine cellular response to catecholamine stimulus signal transduction G protein-coupled dopamine receptor signaling pathway cellular response to organic cyclic compound cellular response to oxygen-containing compound adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cellular response to chemical stimulus cellular response to monoamine stimulus adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway response to light stimulus visual learning visual behavior associative learning response to radiation response to abiotic stimulus organic anion transport carboxylic acid transport arachidonate transport lipid localization lipid transport organic acid transport arachidonate secretion monocarboxylic acid transport fatty acid transport icosanoid transport icosanoid secretion long-chain fatty acid transport positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization regulation of mitotic nuclear division positive regulation of mitotic nuclear division mitotic cell cycle cellular component organization regulation of mitotic cell cycle cellular component organization or biogenesis mitotic nuclear division organelle fission positive regulation of nuclear division regulation of organelle organization organelle organization nuclear division mitotic cell cycle process regulation of nuclear division regulation of biosynthetic process rhythmic process circadian regulation of gene expression circadian rhythm regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process response to histamine amine metabolic process catecholamine metabolic process phenol-containing compound metabolic process organic hydroxy compound metabolic process dopamine metabolic process catechol-containing compound metabolic process biogenic amine metabolic process startle response regulation of response to external stimulus neuromuscular process negative regulation of response to stimulus prepulse inhibition response to external stimulus regulation of response to stimulus negative regulation of response to external stimulus positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade regulation of cell communication positive regulation of signaling adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway adrenergic receptor signaling pathway regulation of potassium ion transport regulation of monoatomic ion transport metal ion transport monoatomic ion transport potassium ion transport monoatomic cation transport regulation of metal ion transport regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of cell communication negative regulation of signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction multicellular organismal movement musculoskeletal movement reflex musculoskeletal movement, spinal reflex action modulation of chemical synaptic transmission synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic negative regulation of synaptic transmission regulation of trans-synaptic signaling negative regulation of synaptic transmission, glutamatergic response to morphine response to isoquinoline alkaloid regulation of biological quality negative regulation of cytosolic calcium ion concentration biological process involved in intraspecies interaction between organisms social behavior regulation of dopamine receptor signaling pathway regulation of G protein-coupled receptor signaling pathway positive regulation of G protein-coupled receptor signaling pathway positive regulation of dopamine receptor signaling pathway acid secretion adenylate cyclase-activating dopamine receptor signaling pathway negative adaptation of signaling pathway receptor internalization desensitization of G protein-coupled receptor signaling pathway negative regulation of G protein-coupled receptor signaling pathway vesicle-mediated transport G protein-coupled receptor internalization adaptation of signaling pathway receptor-mediated endocytosis endocytosis circulatory system process regulation of blood pressure negative regulation of blood pressure blood circulation phospholipase C-activating dopamine receptor signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway biological process involved in interspecies interaction between organisms response to other organism defense response response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus carbohydrate derivative catabolic process catabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process aminoglycan metabolic process peptidoglycan metabolic process symbiont-mediated cytolysis of host cell viral life cycle disruption of cell in another organism cytolysis biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis disruption of cellular anatomical structure in another organism exit from host cell viral process cytolysis in another organism viral release from host cell disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing disruption of plasma membrane integrity in another organism cell wall organization or biogenesis cell wall macromolecule catabolic process cell wall macromolecule metabolic process	cell periphery cellular anatomical structure plasma membrane membrane synapse cell junction host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000276	G protein-coupled receptor, rhodopsin-like	Family
A, B	IPR000929	Dopamine receptor family	Family
A, B	IPR017452	GPCR, rhodopsin-like, 7TM	Domain
A, B	IPR001620	Dopamine D3 receptor	Family
A, B	IPR052619	Bacteriophage lysozyme-like	Family
A, B	IPR001165	T4-type lysozyme	Family
A, B	IPR034690	Endolysin T4 type	Family
A, B	IPR002196	Glycoside hydrolase, family 24	Family
A, B	IPR023347	Lysozyme domain superfamily	Homologous Superfamily
A, B	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P35462	schizophrenia tremor, hereditary essential, 1 Tourette syndrome intermittent explosive disorder alcohol abuse amphetamine abuse basal ganglia disease cocaine abuse visual epilepsy Cognition Disorders cocaine dependence kleptomania delirium movement disorder drug-induced dyskinesia schizophrenia tremor, hereditary essential, 1 Tourette syndrome intermittent explosive disorder alcohol abuse amphetamine abuse basal ganglia disease cocaine abuse visual epilepsy Cognition Disorders cocaine dependence kleptomania delirium movement disorder drug-induced dyskinesia pathological gambling depressive disorder major depressive disorder opiate dependence autism bipolar disorder impulse control disorder

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	G-protein coupled receptors, family A

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class A	Dopamine D₃ receptor complexed with D2/D3-selective antagonist

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.