Annotations: 3Q3D

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Putative DNA-binding domain	8038782	3000158	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Probable bacterial effector-binding domain	8038783	3000062	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Dimerization domain of Mer-like transcriptional regulators	8093204	3002692	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MerR_1	e3q3dA1	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: MerR_1	ECOD (1.6)
A	GyrI-like	e3q3dA2	A: a+b duplicates or obligate multimers	X: Probable bacterial effector-binding domain (From Topology)	H: Probable bacterial effector-binding domain (From Topology)	T: Probable bacterial effector-binding domain	F: GyrI-like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1660.10	Mainly Alpha	Orthogonal Bundle	Multidrug-efflux Transporter Regulator	Chain: A	CATH (4.3.0)
A	1.20.5.490	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Single helix bin	CATH (4.3.0)
A	3.20.80.10	Alpha Beta	Alpha-Beta Barrel	Multidrug-efflux Transporter 1 Regulator Bmrr	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF06445	GyrI-like small molecule binding domain (GyrI-like)	GyrI-like small molecule binding domain	This family contains the small molecule binding domain of a number of different bacterial transcription activators [1]. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecu ...	This family contains the small molecule binding domain of a number of different bacterial transcription activators [1]. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding [3]. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira [3].	Domain
A	PF00376	MerR family regulatory protein (MerR)	MerR family regulatory protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Multidrug-efflux transporter 1 regulator	DNA binding binding organic cyclic compound binding nucleic acid binding transcription regulator activity DNA-binding transcription factor activity	-	-
B	BmrR promoter DNA	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009061	Putative DNA-binding domain superfamily	Homologous Superfamily
A	IPR047057	MerR transcriptional regulator	Family
A	IPR011256	Regulatory factor, effector binding domain superfamily	Homologous Superfamily
A	IPR029442	GyrI-like small molecule binding domain	Domain
A	IPR000551	MerR-type HTH domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.