Annotations: 3Q47

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	TPR_11_4	e3q47B1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF12895	Anaphase-promoting complex, cyclosome, subunit 3 (ANAPC3)	Anaphase-promoting complex, cyclosome, subunit 3	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	STIP1 homology and U box-containing protein 1	SMAD binding protein binding binding R-SMAD binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity SMAD binding protein binding binding R-SMAD binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity misfolded protein binding heat shock protein binding protein-folding chaperone binding protein-macromolecule adaptor activity molecular adaptor activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding Hsp90 protein binding Hsp70 protein binding kinase binding identical protein binding protein homodimerization activity protein dimerization activity TPR domain binding protein domain specific binding signaling receptor binding G protein-coupled receptor binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding negative regulation of molecular function cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process regulation of protein stability biological regulation regulation of biological quality protein stabilization regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding negative regulation of molecular function cellular response to stimulus catabolic process response to stimulus proteolysis involved in protein catabolic process response to nitrogen compound proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process ERAD pathway cellular response to stress response to chemical response to stress proteolysis cellular process metabolic process protein metabolic process macromolecule metabolic process response to endoplasmic reticulum stress cellular biosynthetic process cellular metabolic process gene expression macromolecule biosynthetic process protein maturation protein folding biosynthetic process response to ischemia response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia response to oxygen levels response to abiotic stimulus cellular response to heat response to heat response to temperature stimulus protein autoubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of proteasomal protein catabolic process positive regulation of protein metabolic process positive regulation of biological process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process positive regulation of macromolecule metabolic process regulation of biological process regulation of protein metabolic process regulation of macromolecule metabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of metabolic process regulation of protein catabolic process regulation of cellular process signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction regulation of hormone metabolic process regulation of hormone levels steroid metabolic process regulation of steroid metabolic process regulation of lipid metabolic process regulation of cellular metabolic process hormone metabolic process glucocorticoid metabolic process regulation of glucocorticoid metabolic process lipid metabolic process protein polyubiquitination negative regulation of transforming growth factor beta receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus negative regulation of signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus negative regulation of cellular process enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA damage response DNA repair regulation of cellular component organization positive regulation of cellular component organization protein-containing complex organization positive regulation of cellular component biogenesis regulation of chaperone-mediated protein complex assembly regulation of cellular component biogenesis cellular component organization cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly chaperone-mediated protein complex assembly protein-containing complex assembly cellular component organization or biogenesis positive regulation of chaperone-mediated protein complex assembly positive regulation of cellular process cellular response to misfolded protein response to misfolded protein cellular response to topologically incorrect protein response to topologically incorrect protein autophagy cellular catabolic process chaperone-mediated autophagy process utilizing autophagic mechanism protein monoubiquitination endoplasmic reticulum unfolded protein response cellular response to unfolded protein response to unfolded protein regulation of protein modification process regulation of catalytic activity regulation of protein ubiquitination regulation of transferase activity positive regulation of post-translational protein modification positive regulation of molecular function positive regulation of protein modification process regulation of ubiquitin-protein transferase activity regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination positive regulation of transferase activity regulation of post-translational protein modification positive regulation of catalytic activity positive regulation of ubiquitin-protein transferase activity positive regulation of programmed cell death positive regulation of smooth muscle cell apoptotic process muscle cell apoptotic process smooth muscle cell apoptotic process regulation of apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death cell death regulation of smooth muscle cell apoptotic process positive regulation of apoptotic process positive regulation of muscle cell apoptotic process apoptotic process programmed cell death protein K63-linked ubiquitination macroautophagy positive regulation of cellular metabolic process regulation of autophagy positive regulation of autophagy of mitochondrion mitophagy regulation of autophagy of mitochondrion positive regulation of macroautophagy positive regulation of autophagy positive regulation of mitophagy regulation of mitophagy regulation of macroautophagy regulation of cellular catabolic process positive regulation of cellular catabolic process autophagy of mitochondrion protein quality control for misfolded or incompletely synthesized proteins negative regulation of programmed cell death negative regulation of smooth muscle cell apoptotic process negative regulation of apoptotic process negative regulation of muscle cell apoptotic process regulation of cellular response to stress regulation of ERAD pathway positive regulation of ERAD pathway regulation of response to endoplasmic reticulum stress positive regulation of response to stimulus positive regulation of response to endoplasmic reticulum stress regulation of response to stress	intracellular anatomical structure cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex intracellular anatomical structure cellular anatomical entity Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cytosol protein-containing complex protein folding chaperone complex intracellular protein-containing complex membrane-bounded organelle inclusion body nucleus intracellular membrane-bounded organelle nuclear inclusion body ubiquitin ligase complex catalytic complex transferase complex mitochondrion membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen ubiquitin conjugating enzyme complex endoplasmic reticulum endomembrane system
B [auth C]	Smad1 peptide	co-SMAD binding SMAD binding protein binding binding RNA binding primary miRNA binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity I-SMAD binding enzyme binding DEAD/H-box RNA helicase binding co-SMAD binding SMAD binding protein binding binding RNA binding primary miRNA binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity I-SMAD binding enzyme binding DEAD/H-box RNA helicase binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity cation binding ion binding metal ion binding small molecule binding identical protein binding DNA binding sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding kinase binding protein kinase binding	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development head development brain development nervous system development central nervous system development developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development head development brain development nervous system development central nervous system development hindbrain development heart development heart growth cell population proliferation developmental growth cardiac muscle tissue development cardiac muscle cell proliferation growth organ growth striated muscle tissue development circulatory system development muscle cell proliferation cellular process cardiac muscle tissue growth muscle tissue development striated muscle cell proliferation regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process bone development regulation of developmental process cellular developmental process negative regulation of developmental process negative regulation of biological process negative regulation of muscle cell differentiation regulation of cell differentiation muscle cell differentiation muscle structure development regulation of muscle cell differentiation cell differentiation negative regulation of cellular process negative regulation of cell differentiation RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of primary metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of miRNA transcription positive regulation of miRNA metabolic process miRNA transcription regulation of RNA biosynthetic process positive regulation of RNA biosynthetic process regulation of miRNA transcription cellular response to stimulus response to stimulus signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction ossification transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II cellular response to chemical stimulus response to chemical cellular response to organic cyclic compound response to organic cyclic compound cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cell surface receptor signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway regulation of cartilage development regulation of multicellular organismal development positive regulation of developmental process positive regulation of multicellular organismal process positive regulation of cartilage development regulation of multicellular organismal process midbrain development cellular response to BMP stimulus response to BMP BMP signaling pathway sexual reproduction reproductive process multicellular organismal reproductive process gamete generation osteoblast fate commitment cell fate commitment osteoblast differentiation anatomical structure morphogenesis formation of primary germ layer mesodermal cell differentiation mesoderm morphogenesis embryonic morphogenesis embryo development gastrulation cell fate commitment involved in formation of primary germ layer tissue morphogenesis anatomical structure formation involved in morphogenesis mesodermal cell fate commitment mesoderm formation mesoderm development ureteric bud development mesonephric epithelium development epithelium development kidney epithelium development mesonephros development tube development renal system development kidney development mesonephric tubule development SMAD protein signal transduction cardiac conduction system development negative regulation of cell population proliferation regulation of cell population proliferation regulation of osteoblast differentiation positive regulation of osteoblast differentiation positive regulation of cell differentiation regulation of sprouting angiogenesis angiogenesis regulation of vasculature development tube morphogenesis positive regulation of sprouting angiogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis positive regulation of angiogenesis sprouting angiogenesis vasculature development positive regulation of vasculature development regulation of angiogenesis negative regulation of cellular metabolic process RNA processing negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process regulatory ncRNA processing regulatory ncRNA-mediated gene silencing primary miRNA processing negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process miRNA processing defense response response to stress inflammatory response embryonic pattern specification pattern specification process homeostatic process	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol intracellular organelle organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol intracellular organelle organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex nucleus heteromeric SMAD protein complex nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle SMAD protein complex organelle inner membrane nuclear membrane endomembrane system organelle envelope nuclear inner membrane nuclear envelope organelle membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen homomeric SMAD protein complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR019734	Tetratricopeptide repeat	Repeat
A [auth B]	IPR003613	U-box domain	Domain
A [auth B]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A [auth B]	IPR045202	CHIP , U-box domain	Domain
A [auth B]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A [auth B]	IPR041312	CHIP, N-terminal tetratricopeptide repeat domain	Domain
B [auth C]	IPR036578	SMAD MH1 domain superfamily	Homologous Superfamily
B [auth C]	IPR017855	SMAD-like domain superfamily	Homologous Superfamily
B [auth C]	IPR013019	MAD homology, MH1	Domain
B [auth C]	IPR013790	Dwarfin	Family
B [auth C]	IPR003619	MAD homology 1, Dwarfin-type	Domain
B [auth C]	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
B [auth C]	IPR001132	SMAD domain, Dwarfin-type	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth C]	Pharos: Q15797	psoriasis acute myeloid leukemia astrocytic tumor Emery-Dreifuss muscular dystrophy juvenile dermatomyositis medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pulmonary arterial hypertension adrenoleukodystrophy cystic fibrosis glioblastoma malignant ependymoma myopathy pancreatic ductal adenocarcinoma psoriasis acute myeloid leukemia astrocytic tumor Emery-Dreifuss muscular dystrophy juvenile dermatomyositis medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm pulmonary arterial hypertension adrenoleukodystrophy cystic fibrosis glioblastoma malignant ependymoma myopathy pancreatic ductal adenocarcinoma Pick disease tuberculosis amyotrophic lateral sclerosis Duchenne muscular dystrophy idiopathic pulmonary arterial hypertension malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.