Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AAMP-binding_3rde3rg2A8 A: beta barrelsX: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)T: beta-barrel domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_3rdECOD (1.6)
APP-bindinge3rg2A10 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: PP-bindingECOD (1.6)
AAMP-binding_Ce3rg2A7 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: a+b domain in acetyl-CoA synthetase-like proteins (From Topology)T: a+b domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_CECOD (1.6)
AAMP-binding_1ste3rg2A9 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_1stECOD (1.6)
AAMP-binding_2nde3rg2A6 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_2ndECOD (1.6)
BAMP-binding_3rde3rg2B8 A: beta barrelsX: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)T: beta-barrel domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_3rdECOD (1.6)
BPP-bindinge3rg2B10 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: PP-bindingECOD (1.6)
BAMP-binding_Ce3rg2B7 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: a+b domain in acetyl-CoA synthetase-like proteins (From Topology)T: a+b domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_CECOD (1.6)
BAMP-binding_1ste3rg2B9 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_1stECOD (1.6)
BAMP-binding_2nde3rg2B6 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_2ndECOD (1.6)
CAMP-binding_3rde3rg2C8 A: beta barrelsX: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)T: beta-barrel domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_3rdECOD (1.6)
CPP-bindinge3rg2C10 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: PP-bindingECOD (1.6)
CAMP-binding_Ce3rg2C7 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: a+b domain in acetyl-CoA synthetase-like proteins (From Topology)T: a+b domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_CECOD (1.6)
CAMP-binding_1ste3rg2C9 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_1stECOD (1.6)
CAMP-binding_2nde3rg2C6 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_2ndECOD (1.6)
DAMP-binding_3rde3rg2D8 A: beta barrelsX: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)T: beta-barrel domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_3rdECOD (1.6)
DPP-bindinge3rg2D10 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: PP-bindingECOD (1.6)
DAMP-binding_Ce3rg2D7 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: a+b domain in acetyl-CoA synthetase-like proteins (From Topology)T: a+b domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_CECOD (1.6)
DAMP-binding_1ste3rg2D9 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_1stECOD (1.6)
DAMP-binding_2nde3rg2D6 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_2ndECOD (1.6)
EAMP-binding_3rde3rg2E13 A: beta barrelsX: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)T: beta-barrel domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_3rdECOD (1.6)
EPP-bindinge3rg2E15 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: PP-bindingECOD (1.6)
EAMP-binding_Ce3rg2E12 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: a+b domain in acetyl-CoA synthetase-like proteins (From Topology)T: a+b domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_CECOD (1.6)
EAMP-binding_1ste3rg2E14 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_1stECOD (1.6)
EAMP-binding_2nde3rg2E11 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_2ndECOD (1.6)
FAMP-binding_3rde3rg2F8 A: beta barrelsX: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)T: beta-barrel domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_3rdECOD (1.6)
FPP-bindinge3rg2F10 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: PP-bindingECOD (1.6)
FAMP-binding_Ce3rg2F7 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: a+b domain in acetyl-CoA synthetase-like proteins (From Topology)T: a+b domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_CECOD (1.6)
FAMP-binding_1ste3rg2F9 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_1stECOD (1.6)
FAMP-binding_2nde3rg2F6 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_2ndECOD (1.6)
GAMP-binding_3rde3rg2G8 A: beta barrelsX: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)T: beta-barrel domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_3rdECOD (1.6)
GPP-bindinge3rg2G10 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: PP-bindingECOD (1.6)
GAMP-binding_Ce3rg2G7 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: a+b domain in acetyl-CoA synthetase-like proteins (From Topology)T: a+b domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_CECOD (1.6)
GAMP-binding_1ste3rg2G9 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_1stECOD (1.6)
GAMP-binding_2nde3rg2G6 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_2ndECOD (1.6)
HAMP-binding_3rde3rg2H8 A: beta barrelsX: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)T: beta-barrel domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_3rdECOD (1.6)
HPP-bindinge3rg2H10 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: PP-bindingECOD (1.6)
HAMP-binding_Ce3rg2H7 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: a+b domain in acetyl-CoA synthetase-like proteins (From Topology)T: a+b domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_CECOD (1.6)
HAMP-binding_1ste3rg2H9 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_1stECOD (1.6)
HAMP-binding_2nde3rg2H6 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_2ndECOD (1.6)
IAMP-binding_3rde3rg2I8 A: beta barrelsX: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)T: beta-barrel domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_3rdECOD (1.6)
IPP-bindinge3rg2I10 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: PP-bindingECOD (1.6)
IAMP-binding_Ce3rg2I7 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: a+b domain in acetyl-CoA synthetase-like proteins (From Topology)T: a+b domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_CECOD (1.6)
IAMP-binding_1ste3rg2I9 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_1stECOD (1.6)
IAMP-binding_2nde3rg2I6 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_2ndECOD (1.6)
JAMP-binding_3rde3rg2J8 A: beta barrelsX: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology)T: beta-barrel domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_3rdECOD (1.6)
JPP-bindinge3rg2J10 A: alpha bundlesX: ACP-likeH: Acyl-carrier protein (ACP) (From Topology)T: Acyl-carrier protein (ACP)F: PP-bindingECOD (1.6)
JAMP-binding_Ce3rg2J7 A: a+b two layersX: Alpha-lytic protease prodomain-likeH: a+b domain in acetyl-CoA synthetase-like proteins (From Topology)T: a+b domain in acetyl-CoA synthetase-like proteinsF: AMP-binding_CECOD (1.6)
JAMP-binding_1ste3rg2J9 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_1stECOD (1.6)
JAMP-binding_2nde3rg2J6 A: a/b three-layered sandwichesX: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology)T: Rossmann-like domain in Acetyl-CoA synthetase-like proteinsF: AMP-binding_2ndECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.12780 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold ANL, N-terminal domainCATH (4.3.0)
A3.30.300.30 Alpha Beta 2-Layer Sandwich GMP Synthetase Chain A, domain 3CATH (4.3.0)
A1.10.1200.10 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein Chain ACATH (4.3.0)
B3.40.50.12780 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold ANL, N-terminal domainCATH (4.3.0)
B3.30.300.30 Alpha Beta 2-Layer Sandwich GMP Synthetase Chain A, domain 3CATH (4.3.0)
B1.10.1200.10 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein Chain ACATH (4.3.0)
C3.40.50.12780 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold ANL, N-terminal domainCATH (4.3.0)
C3.30.300.30 Alpha Beta 2-Layer Sandwich GMP Synthetase Chain A, domain 3CATH (4.3.0)
C1.10.1200.10 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein Chain ACATH (4.3.0)
D3.40.50.12780 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold ANL, N-terminal domainCATH (4.3.0)
D3.30.300.30 Alpha Beta 2-Layer Sandwich GMP Synthetase Chain A, domain 3CATH (4.3.0)
D1.10.1200.10 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein Chain ACATH (4.3.0)
E3.40.50.12780 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold ANL, N-terminal domainCATH (4.3.0)
E3.30.300.30 Alpha Beta 2-Layer Sandwich GMP Synthetase Chain A, domain 3CATH (4.3.0)
E1.10.1200.10 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein Chain ACATH (4.3.0)
F3.40.50.12780 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold ANL, N-terminal domainCATH (4.3.0)
F3.30.300.30 Alpha Beta 2-Layer Sandwich GMP Synthetase Chain A, domain 3CATH (4.3.0)
F1.10.1200.10 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein Chain ACATH (4.3.0)
G3.40.50.12780 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold ANL, N-terminal domainCATH (4.3.0)
G3.30.300.30 Alpha Beta 2-Layer Sandwich GMP Synthetase Chain A, domain 3CATH (4.3.0)
G1.10.1200.10 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein Chain ACATH (4.3.0)
H3.40.50.12780 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold ANL, N-terminal domainCATH (4.3.0)
H3.30.300.30 Alpha Beta 2-Layer Sandwich GMP Synthetase Chain A, domain 3CATH (4.3.0)
H1.10.1200.10 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein Chain ACATH (4.3.0)
I3.40.50.12780 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold ANL, N-terminal domainCATH (4.3.0)
I3.30.300.30 Alpha Beta 2-Layer Sandwich GMP Synthetase Chain A, domain 3CATH (4.3.0)
I1.10.1200.10 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein Chain ACATH (4.3.0)
J3.40.50.12780 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold ANL, N-terminal domainCATH (4.3.0)
J3.30.300.30 Alpha Beta 2-Layer Sandwich GMP Synthetase Chain A, domain 3CATH (4.3.0)
J1.10.1200.10 Mainly Alpha Orthogonal Bundle Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein Chain ACATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00501AMP-binding enzyme (AMP-binding)AMP-binding enzyme- Family
A, B, C, D, E
PF13193AMP-binding enzyme C-terminal domain (AMP-binding_C)AMP-binding enzyme C-terminal domainThis is a small domain that is found C terminal to Pfam:PF00501. It has a central beta sheet core that is flanked by alpha helices.Domain
A, B, C, D, E
PF00550Phosphopantetheine attachment site (PP-binding)Phosphopantetheine attachment siteA 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes memb ...A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Enterobactin synthase component E (entE), 2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochroismatase (Entb)

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR009081Phosphopantetheine binding ACP domainDomain
A, B, C, D, E
IPR000868Isochorismatase-likeDomain
A, B, C, D, E
IPR050272Isochorismatase-like hydrolaseFamily
A, B, C, D, E
IPR036380Isochorismatase-like superfamilyHomologous Superfamily
A, B, C, D, E
IPR036736ACP-like superfamilyHomologous Superfamily
A, B, C, D, E
IPR016291IsochorismataseFamily
A, B, C, D, E
IPR0119632,3-dihydroxybenzoate-AMP ligaseFamily
A, B, C, D, E
IPR050237ATP-dependent AMP-binding enzymeFamily
A, B, C, D, E
IPR020845AMP-binding, conserved siteConserved Site
A, B, C, D, E
IPR045851AMP-binding enzyme, C-terminal domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR042099ANL, N-terminal domainHomologous Superfamily
A, B, C, D, E
IPR025110AMP-binding enzyme, C-terminal domainDomain
A, B, C, D, E
IPR000873AMP-dependent synthetase/ligase domainDomain