3SQ6

Crystal Structures of the Ligand Binding Domain of a Pentameric Alpha7 Nicotinic Receptor Chimera with its Agonist Epibatidine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3sq6a_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ], great pond snail (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
B	d3sq6b_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ], great pond snail (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
C	d3sq6c_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ], great pond snail (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
D	d3sq6d_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ], great pond snail (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
E	d3sq6e_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ], great pond snail (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
G	d3sq6g_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ], great pond snail (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
J	d3sq6j_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ], great pond snail (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
F	d3sq6f_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ], great pond snail (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
H	d3sq6h_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ], great pond snail (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)
I	d3sq6i_	All beta proteins	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	Nicotinic receptor ligand binding domain-like	automated matches	human (Homo sapiens ) [TaxId: 9606 ], great pond snail (Lymnaea stagnalis ) [TaxId: 6523 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Neur_chan_LBD	e3sq6A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
B	Neur_chan_LBD	e3sq6B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
C	Neur_chan_LBD	e3sq6C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
D	Neur_chan_LBD	e3sq6D1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
E	Neur_chan_LBD	e3sq6E1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
G	Neur_chan_LBD	e3sq6G1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
J	Neur_chan_LBD	e3sq6J1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
F	Neur_chan_LBD	e3sq6F1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
H	Neur_chan_LBD	e3sq6H1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)
I	Neur_chan_LBD	e3sq6I1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Nicotinic receptor ligand binding domain-like (From Topology)	T: Nicotinic receptor ligand binding domain-like	F: Neur_chan_LBD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
B	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
C	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
D	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
E	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
G	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
J	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
F	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
H	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)
I	2.70.170.10	Mainly Beta	Distorted Sandwich	Acetylcholine Binding Protein	Chain: A,	CATH (4.3.0)

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.