3SWD

E. coli MurA in complex with UDP-N-acetylmuramic acid and covalent adduct of PEP with Cys115

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3swda_	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	Enolpyruvate transferase, EPT	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B	d3swdb_	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	Enolpyruvate transferase, EPT	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
C	d3swdc_	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	Enolpyruvate transferase, EPT	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
D	d3swdd_	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	Enolpyruvate transferase, EPT	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
E	d3swde_	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	Enolpyruvate transferase, EPT	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
F	d3swdf_	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	Enolpyruvate transferase, EPT	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
G	d3swdg_	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	Enolpyruvate transferase, EPT	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
H	d3swdh_	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	Enolpyruvate transferase, EPT	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
I	d3swdi_	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	Enolpyruvate transferase, EPT	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
K	d3swdk_	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	Enolpyruvate transferase, EPT	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
L	d3swdl_	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	Enolpyruvate transferase, EPT	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
J	d3swdj_	Alpha and beta proteins (a+b)	IF3-like	EPT/RTPC-like	Enolpyruvate transferase, EPT	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EPT/RTPC-like	8035766	3001530	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	EPT/RTPC-like	8035766	3001530	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	EPT/RTPC-like	8035766	3001530	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	EPT/RTPC-like	8035766	3001530	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	EPT/RTPC-like	8035766	3001530	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	EPT/RTPC-like	8035766	3001530	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	EPT/RTPC-like	8035766	3001530	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	EPT/RTPC-like	8035766	3001530	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	EPT/RTPC-like	8035766	3001530	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	EPT/RTPC-like	8035766	3001530	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	EPT/RTPC-like	8035766	3001530	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	EPT/RTPC-like	8035766	3001530	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EPSP_synthase_C_1	e3swdA2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_C_1	ECOD (1.6)
A	EPSP_synthase_N	e3swdA1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_N	ECOD (1.6)
B	EPSP_synthase_C_1	e3swdB1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_C_1	ECOD (1.6)
B	EPSP_synthase_N	e3swdB2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_N	ECOD (1.6)
C	EPSP_synthase_C_1	e3swdC1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_C_1	ECOD (1.6)
C	EPSP_synthase_N	e3swdC2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_N	ECOD (1.6)
D	EPSP_synthase_C_1	e3swdD2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_C_1	ECOD (1.6)
D	EPSP_synthase_N	e3swdD1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_N	ECOD (1.6)
E	EPSP_synthase_C_1	e3swdE2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_C_1	ECOD (1.6)
E	EPSP_synthase_N	e3swdE1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_N	ECOD (1.6)
F	EPSP_synthase_C_1	e3swdF1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_C_1	ECOD (1.6)
F	EPSP_synthase_N	e3swdF2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_N	ECOD (1.6)
G	EPSP_synthase_C_1	e3swdG2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_C_1	ECOD (1.6)
G	EPSP_synthase_N	e3swdG1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_N	ECOD (1.6)
H	EPSP_synthase_C_1	e3swdH2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_C_1	ECOD (1.6)
H	EPSP_synthase_N	e3swdH1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_N	ECOD (1.6)
I	EPSP_synthase_C_1	e3swdI2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_C_1	ECOD (1.6)
I	EPSP_synthase_N	e3swdI1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_N	ECOD (1.6)
K	EPSP_synthase_C_1	e3swdK2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_C_1	ECOD (1.6)
K	EPSP_synthase_N	e3swdK1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_N	ECOD (1.6)
L	EPSP_synthase_C_1	e3swdL1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_C_1	ECOD (1.6)
L	EPSP_synthase_N	e3swdL2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_N	ECOD (1.6)
J	EPSP_synthase_C_1	e3swdJ1	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_C_1	ECOD (1.6)
J	EPSP_synthase_N	e3swdJ2	A: a+b two layers	X: IF3-like	H: EPT/RTPC-like (From Topology)	T: EPT/RTPC-like	F: EPSP_synthase_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
B	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
C	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
D	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
E	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
F	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
G	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
H	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
I	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
K	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
L	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)
J	3.65.10.10	Alpha Beta	Alpha-beta prism	UDP-n-acetylglucosamine1-carboxyvinyl-transferase	Chain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF00275	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) (EPSP_synthase)	EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity	developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis carbohydrate derivative biosynthetic process peptidoglycan-based cell wall biogenesis cell wall organization or biogenesis developmental process regulation of biological process regulation of developmental process biological regulation regulation of cell shape cell morphogenesis regulation of cell morphogenesis anatomical structure morphogenesis anatomical structure development regulation of biological quality regulation of anatomical structure morphogenesis carbohydrate derivative biosynthetic process peptidoglycan-based cell wall biogenesis cell wall organization or biogenesis glycosaminoglycan metabolic process carbohydrate derivative metabolic process macromolecule biosynthetic process cellular component biogenesis peptidoglycan biosynthetic process cell wall biogenesis biosynthetic process cell wall macromolecule biosynthetic process aminoglycan metabolic process peptidoglycan metabolic process aminoglycan biosynthetic process cellular process metabolic process glycosaminoglycan biosynthetic process cellular component organization or biogenesis macromolecule metabolic process nucleoside phosphate metabolic process amino sugar biosynthetic process nucleotide-sugar metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process UDP-N-acetylgalactosamine biosynthetic process organophosphate metabolic process UDP-N-acetylgalactosamine metabolic process nucleobase-containing small molecule metabolic process organophosphate biosynthetic process amino sugar metabolic process phosphate-containing compound metabolic process nucleoside phosphate biosynthetic process small molecule metabolic process phosphorus metabolic process nucleotide-sugar biosynthetic process cell division cellular component organization cell wall organization external encapsulating structure organization	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR001986	Enolpyruvate transferase domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR005750	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR013792	RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR050068	UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA subfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR036968	Enolpyruvate transferase domain superfamily	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IAS
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	QPA	Parent Component: CYS RESID: AA0391 PSI-MOD : 2-(S-L-cysteinyl)pyruvic acid O-phosphothioketal MOD:00797