3T6G

Structure of the complex between NSP3 (SHEP1) and p130Cas

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2 Family	Cas family homology domain (CCHD)-like	8047129	4005458	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	alpha-Catenin/Vinculin-like	8104085	3001619	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	alpha-Catenin/Vinculin-like	8104085	3001619	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RasGEF	e3t6gA2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ras GEF (From Topology)	T: Ras GEF	F: RasGEF	ECOD (1.6)
C	RasGEF	e3t6gC2	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ras GEF (From Topology)	T: Ras GEF	F: RasGEF	ECOD (1.6)
B	DUF3513	e3t6gB1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: DUF3513	ECOD (1.6)
D	DUF3513	e3t6gD1	A: alpha bundles	X: Four-helical up-and-down bundle	H: alpha-catenin-related	T: alpha-catenin/vinculin	F: DUF3513	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.840.10	Mainly Alpha	Orthogonal Bundle	Son of Sevenless (SoS) protein	Chain S, domain 2	CATH (4.3.0)
C	1.10.840.10	Mainly Alpha	Orthogonal Bundle	Son of Sevenless (SoS) protein	Chain S, domain 2	CATH (4.3.0)
B	1.20.120.230	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Alpha-catenin/vinculin-like	CATH (4.3.0)
D	1.20.120.230	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	Alpha-catenin/vinculin-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00617	RasGEF domain (RasGEF)	RasGEF domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	SH2 domain-containing protein 3C	GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity phosphoprotein binding phosphotyrosine residue binding protein binding binding protein phosphorylated amino acid binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication JNK cascade intracellular signaling cassette MAPK cascade cellular process signal transduction positive regulation of phosphorylation cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication JNK cascade intracellular signaling cassette MAPK cascade cellular process signal transduction positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-serine phosphorylation positive regulation of cellular metabolic process positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process small GTPase-mediated signal transduction	ruffle cell leading edge plasma membrane membrane leading edge membrane cellular anatomical entity plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane intracellular anatomical structure cytoplasm ruffle cell leading edge plasma membrane membrane leading edge membrane cellular anatomical entity plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane intracellular anatomical structure cytoplasm cytosol axon neuron projection
B, D	Breast cancer anti-estrogen resistance protein 1	SH3 domain binding protein binding binding protein domain specific binding kinase binding enzyme binding protein kinase binding	cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response B cell receptor signaling pathway biological regulation regulation of response to stimulus immune system process regulation of immune response cellular process antigen receptor-mediated signaling pathway activation of immune response T cell receptor signaling pathway positive regulation of locomotion regulation of cell motility endothelial cell migration positive regulation of cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration cell migration cell motility locomotion positive regulation of cellular process cell division integrin-mediated signaling pathway regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death cell surface receptor protein tyrosine kinase signaling pathway hepatocyte growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway platelet-derived growth factor receptor signaling pathway endothelin receptor signaling pathway G protein-coupled receptor signaling pathway ERBB signaling pathway epidermal growth factor receptor signaling pathway cell chemotaxis chemotaxis response to external stimulus cellular response to chemical stimulus taxis response to chemical cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cellular response to endogenous stimulus response to hormone cellular response to hormone stimulus response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound response to insulin cellular response to insulin stimulus cell adhesion cellular response to growth factor stimulus neurotrophin TRK receptor signaling pathway neurotrophin signaling pathway response to growth factor response to hepatocyte growth factor cellular response to hepatocyte growth factor stimulus organelle organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization cytoskeleton organization vascular endothelial growth factor receptor signaling pathway	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium membrane intracellular organelle intracellular anatomical structure cytoskeleton organelle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction cell projection cell leading edge plasma membrane bounded cell projection lamellipodium membrane intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytoplasm cytosol ruffle axon neuron projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR051853	Adapter protein with SH2 and Ras-GEF domains	Family
A, C	IPR036860	SH2 domain superfamily	Homologous Superfamily
A, C	IPR000980	SH2 domain	Domain
A, C	IPR036964	Ras guanine-nucleotide exchange factor, catalytic domain superfamily	Homologous Superfamily
A, C	IPR044102	SHEP1/BCAR3/NSP1, SH2 domain	Domain
A, C	IPR023578	Ras guanine nucleotide exchange factor domain superfamily	Homologous Superfamily
A, C	IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	Domain
B, D	IPR037362	CAS family	Family
B, D	IPR014928	Serine rich protein interaction domain	Domain
B, D	IPR021901	CAS family, C-terminal	Domain
B, D	IPR036028	SH3-like domain superfamily	Homologous Superfamily
B, D	IPR046976	BCAR1, C-terminal	Domain
B, D	IPR038319	CAS, serine rich four helix bundle domain superfamily	Homologous Superfamily
B, D	IPR035745	BCAR1, SH3 domain	Domain
B, D	IPR001452	SH3 domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: Q8N5H7	chikungunya lung carcinoma non-small cell lung carcinoma cystic fibrosis malignant ependymoma osteosarcoma interstitial cystitis malignant glioma pilocytic astrocytoma
B, D	Pharos: P56945	Neoplasm Invasiveness age-related macular degeneration chronic obstructive pulmonary disease heart disease osteosarcoma alcoholic pancreatitis diabetes mellitus hypertensive disorder malignant pancreatic neoplasm pancreatic neoplasm brain aneurysm exocrine pancreatic carcinoma wet macular degeneration

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.