3TRH

Structure of a phosphoribosylaminoimidazole carboxylase catalytic subunit (purE) from Coxiella burnetii

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3trha_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
C	d3trhc_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
D	d3trhd_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
E	d3trhe_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
F	d3trhf_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
G	d3trhg_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
H	d3trhh_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
I	d3trhi_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
J	d3trhj_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
K	d3trhk_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
L	d3trhl_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
N	d3trhn_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
P	d3trhp_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
B	d3trhb_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
M	d3trhm_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)
O	d3trho_	Alpha and beta proteins (a/b)	Flavodoxin-like	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	automated matches	automated matches	(Coxiella burnetii ) [TaxId: 777 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059316	4003688	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	8059317	3001291	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	AIRC	e3trhA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
C	AIRC	e3trhC1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
D	AIRC	e3trhD1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
E	AIRC	e3trhE1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
F	AIRC	e3trhF1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
G	AIRC	e3trhG1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
H	AIRC	e3trhH1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
I	AIRC	e3trhI1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
J	AIRC	e3trhJ1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
K	AIRC	e3trhK1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
L	AIRC	e3trhL1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
N	AIRC	e3trhN1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
P	AIRC	e3trhP1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
B	AIRC	e3trhB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
M	AIRC	e3trhM1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)
O	AIRC	e3trhO1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)	F: AIRC	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
D	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
E	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
F	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
G	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
H	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
I	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
J	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
K	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
L	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
N	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
P	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
M	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
O	3.40.50.1970	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	PF00731	AIR carboxylase (AIRC)	AIR carboxylase	Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	Phosphoribosylaminoimidazole carboxylase carboxyltransferase subunit	lyase activity catalytic activity isomerase activity 5-(carboxyamino)imidazole ribonucleotide mutase activity intramolecular transferase activity	ribose phosphate metabolic process IMP metabolic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process ribose phosphate metabolic process IMP metabolic process purine ribonucleoside monophosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleoside monophosphate biosynthetic process purine ribonucleoside monophosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine nucleoside monophosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside monophosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process cellular metabolic process primary metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process purine-containing compound metabolic process IMP biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process metabolic process cellular process 'de novo' IMP biosynthetic process purine ribonucleotide metabolic process ribonucleoside monophosphate biosynthetic process purine nucleotide biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR033747	Class I PurE	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR000031	PurE domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR024694	PurE, prokaryotic type	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.