3UVV

Crystal Structure of the ligand binding domains of the thyroid receptor:retinoid X receptor complexed with 3,3',5 triiodo-L-thyronine and 9-cis retinoic acid

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3uvva1	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	automated matches	bantam,chickens (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
A	d3uvva2	Artifacts	Tags	Tags	Tags	N-terminal Tags	bantam,chickens (Gallus gallus ) [TaxId: 9031 ],	SCOPe (2.08)
B	d3uvvb_	All alpha proteins	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Nuclear receptor ligand-binding domain	Retinoid-X receptor alpha (RXR-alpha)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Nuclear receptor ligand-binding domain	8064791	4001384	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Nuclear receptor ligand-binding domain	8064792	3001442	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Nuclear receptor ligand-binding domain	8038695	3001442	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hormone_recep	e3uvvA1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep	ECOD (1.6)
B	Hormone_recep	e3uvvB1	A: alpha arrays	X: Nuclear receptor ligand-binding domain (From Topology)	H: Nuclear receptor ligand-binding domain (From Topology)	T: Nuclear receptor ligand-binding domain	F: Hormone_recep	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)
B	1.10.565.10	Mainly Alpha	Orthogonal Bundle	Retinoid X Receptor	Retinoid X Receptor	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Thyroid hormone receptor alpha	protein binding binding protein domain specific binding thyroid hormone binding hormone binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding protein binding binding protein domain specific binding thyroid hormone binding hormone binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription factor binding TBP-class protein binding general transcription initiation factor binding nuclear receptor activity DNA-binding transcription factor activity, RNA polymerase II-specific molecular transducer activity transcription regulator activity ligand-activated transcription factor activity DNA-binding transcription factor activity signaling receptor activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus intracellular receptor signaling pathway signaling positive regulation of biological process regulation of signal transduction regulation of thyroid hormone receptor signaling pathway hormone-mediated signaling pathway intracellular signal transduction cell communication positive regulation of response to stimulus cellular response to endogenous stimulus cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus intracellular receptor signaling pathway signaling positive regulation of biological process regulation of signal transduction regulation of thyroid hormone receptor signaling pathway hormone-mediated signaling pathway intracellular signal transduction cell communication positive regulation of response to stimulus cellular response to endogenous stimulus regulation of intracellular signal transduction response to hormone positive regulation of thyroid hormone receptor signaling pathway signal transduction positive regulation of cellular process cellular response to hormone stimulus regulation of biological process regulation of signaling response to endogenous stimulus biological regulation thyroid hormone receptor signaling pathway positive regulation of intracellular signal transduction cellular response to chemical stimulus regulation of response to stimulus response to chemical regulation of cell communication cellular process nuclear receptor-mediated signaling pathway positive regulation of signaling developmental process cellular developmental process cell differentiation retinoic acid receptor signaling pathway negative regulation of transcription initiation by RNA polymerase II transcription preinitiation complex assembly negative regulation of biological process regulation of primary metabolic process negative regulation of RNA biosynthetic process cellular component biogenesis nucleobase-containing compound metabolic process DNA-templated transcription regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of cellular component organization negative regulation of transcription by RNA polymerase II negative regulation of metabolic process primary metabolic process negative regulation of protein-containing complex assembly regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process RNA polymerase II preinitiation complex assembly metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization negative regulation of RNA polymerase II transcription preinitiation complex assembly RNA metabolic process cellular component organization protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process regulation of protein-containing complex assembly protein-containing complex assembly negative regulation of cellular process cellular component organization or biogenesis regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process protein-containing complex organization protein-DNA complex assembly regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression regulation of cellular component biogenesis macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process negative regulation of biosynthetic process regulation of transcription initiation by RNA polymerase II negative regulation of DNA-templated transcription initiation mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle intracellular organelle cellular anatomical structure organelle cytoplasm cytosol
B	Retinoic acid receptor RXR-alpha	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding transcription coregulator binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding transcription coregulator binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity LBD domain binding protein domain specific binding nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity retinoic acid binding organic acid binding isoprenoid binding retinoid binding ion binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding identical protein binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear vitamin D receptor binding retinoic acid-responsive element binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding nuclear steroid receptor activity DNA binding domain binding peptide binding cation binding transition metal ion binding zinc ion binding metal ion binding enzyme binding	positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process regulation of transport biological regulation lipid localization lipid transport positive regulation of lipid localization establishment of localization positive regulation of lipid transport positive regulation of transport regulation of lipid localization macromolecule localization cholesterol transport cholesterol efflux regulation of transporter activity positive regulation of molecular function regulation of molecular function positive regulation of transporter activity multicellular organismal process regulation of developmental process regulation of biomineral tissue development regulation of bone mineralization positive regulation of ossification positive regulation of developmental process multicellular organism development positive regulation of biomineral tissue development ossification anatomical structure development biomineral tissue development regulation of multicellular organismal process developmental process regulation of multicellular organismal development bone mineralization animal organ development tissue development positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification cellular response to stimulus regulation of cellular process intracellular receptor signaling pathway response to stimulus signaling response to endogenous stimulus retinoic acid receptor signaling pathway hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular process signal transduction nuclear receptor-mediated signaling pathway cellular response to hormone stimulus peroxisome proliferator activated receptor signaling pathway mRNA transcription by RNA polymerase II RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression mRNA transcription mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process macromolecule metabolic process negative regulation of biological process regulation of primary metabolic process negative regulation of RNA biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process regulation of macromolecule metabolic process regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction regulation of thyroid hormone receptor signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of thyroid hormone receptor signaling pathway regulation of signaling thyroid hormone receptor signaling pathway positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling cellular developmental process cell differentiation response to retinoic acid response to lipid response to oxygen-containing compound regulation of response to nutrient levels cellular response to vitamin D response to vitamin D response to organic cyclic compound cellular response to organic cyclic compound cellular response to oxygen-containing compound cellular response to nutrient levels cellular response to lipid regulation of vitamin D receptor signaling pathway response to nutrient levels response to vitamin response to nutrient vitamin D receptor signaling pathway cellular response to vitamin positive regulation of vitamin D receptor signaling pathway cellular response to nutrient	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome receptor complex membrane-bounded organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex transcription regulator complex intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome receptor complex membrane-bounded organelle mitochondrion intracellular membrane-bounded organelle RNA polymerase II transcription regulator complex nucleus nuclear protein-containing complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
A	IPR050234	Nuclear hormone receptor family NR1 subfamily	Family
A	IPR001723	Nuclear hormone receptor	Family
A	IPR001728	Thyroid hormone receptor	Family
A	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
A	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily
B	IPR001628	Zinc finger, nuclear hormone receptor-type	Domain
B	IPR021780	Nuclear/hormone receptor activator site AF-1	Domain
B	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
B	IPR000003	Retinoid X receptor/HNF4	Family
B	IPR050274	Nuclear hormone receptor family NR2 subfamily	Family
B	IPR001723	Nuclear hormone receptor	Family
B	IPR000536	Nuclear hormone receptor, ligand-binding domain	Domain
B	IPR035500	Nuclear hormone receptor-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: P19793	prostate cancer lesion of sciatic nerve sciatic neuropathy thyroid gland carcinoma amyotrophic lateral sclerosis type 1 thyroid adenoma malignant mesothelioma Sciatic Neuritis thyroid cancer astrocytic tumor invasive ductal breast carcinoma MALT lymphoma osteosarcoma pituitary cancer B-cell chronic lymphocytic leukemia prostate cancer lesion of sciatic nerve sciatic neuropathy thyroid gland carcinoma amyotrophic lateral sclerosis type 1 thyroid adenoma malignant mesothelioma Sciatic Neuritis thyroid cancer astrocytic tumor invasive ductal breast carcinoma MALT lymphoma osteosarcoma pituitary cancer B-cell chronic lymphocytic leukemia lung carcinoma medulloblastoma ovarian cancer primary cutaneous T-cell lymphoma interstitial cystitis large cell medulloblastoma pancreatic ductal adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.