3CX5

Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3cx5a1	Alpha and beta proteins (a+b)	LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	MPP-like	Cytochrome bc1 core subunit 1	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
L	d3cx5l1	Alpha and beta proteins (a+b)	LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	MPP-like	Cytochrome bc1 core subunit 1	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
G	d3cx5g_	Membrane and cell surface proteins and peptides	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	automated matches	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
R	d3cx5r_	Membrane and cell surface proteins and peptides	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	automated matches	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
H	d3cx5h_	Membrane and cell surface proteins and peptides	Single transmembrane helix	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
S	d3cx5s_	Membrane and cell surface proteins and peptides	Single transmembrane helix	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
I	d3cx5i_	Membrane and cell surface proteins and peptides	Single transmembrane helix	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	automated matches	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
T	d3cx5t_	Membrane and cell surface proteins and peptides	Single transmembrane helix	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	automated matches	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
J	d3cx5j_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Immunoglobulin heavy chain variable domain, VH	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
U	d3cx5u_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Immunoglobulin heavy chain variable domain, VH	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
K	d3cx5k_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Immunoglobulin light chain kappa variable domain, VL-kappa	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
V	d3cx5v_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	Immunoglobulin light chain kappa variable domain, VL-kappa	house mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
W	d3cx5w_	All alpha proteins	Cytochrome c	Cytochrome c	monodomain cytochrome c	Mitochondrial cytochrome c	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
B	d3cx5b1	Alpha and beta proteins (a+b)	LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	MPP-like	Cytochrome bc1 core subunit 2	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
M	d3cx5m1	Alpha and beta proteins (a+b)	LuxS/MPP-like metallohydrolase	LuxS/MPP-like metallohydrolase	MPP-like	Cytochrome bc1 core subunit 2	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d3cx5c2	Membrane and cell surface proteins and peptides	Heme-binding four-helical bundle	Transmembrane di-heme cytochromes	Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	automated matches	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
C	d3cx5c1	Membrane and cell surface proteins and peptides	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	automated matches	automated matches	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
N	d3cx5n2	Membrane and cell surface proteins and peptides	Heme-binding four-helical bundle	Transmembrane di-heme cytochromes	Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	automated matches	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
N	d3cx5n1	Membrane and cell surface proteins and peptides	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	automated matches	automated matches	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
D	d3cx5d1	All alpha proteins	Cytochrome c	Cytochrome c	Cytochrome bc1 domain	Cytochrome bc1 domain	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
D	d3cx5d2	Membrane and cell surface proteins and peptides	Single transmembrane helix	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
O	d3cx5o1	All alpha proteins	Cytochrome c	Cytochrome c	Cytochrome bc1 domain	Cytochrome bc1 domain	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
O	d3cx5o2	Membrane and cell surface proteins and peptides	Single transmembrane helix	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
E	d3cx5e1	All beta proteins	ISP domain	ISP domain	Rieske iron-sulfur protein (ISP)	ISP subunit of the mitochondrial cytochrome bc1-complex, water-soluble domain	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
E	d3cx5e2	Membrane and cell surface proteins and peptides	Single transmembrane helix	ISP transmembrane anchor	ISP transmembrane anchor	Iron-sulfur subunit (ISP) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane region	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
P	d3cx5p1	All beta proteins	ISP domain	ISP domain	Rieske iron-sulfur protein (ISP)	ISP subunit of the mitochondrial cytochrome bc1-complex, water-soluble domain	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
P	d3cx5p2	Membrane and cell surface proteins and peptides	Single transmembrane helix	ISP transmembrane anchor	ISP transmembrane anchor	Iron-sulfur subunit (ISP) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane region	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
F	d3cx5f_	Membrane and cell surface proteins and peptides	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	automated matches	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)
Q	d3cx5q_	Membrane and cell surface proteins and peptides	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	automated matches	(Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	MPP-like	8027913	4002871	SCOP2 (2022-06-29)
A	SCOP2 Family	MPP-like	8027915	4002871	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	LuxS/MPP-like metallohydrolase	8040292	3001831	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	LuxS/MPP-like metallohydrolase	8040294	3001831	SCOP2 (2022-06-29)
L	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8040292	3001831	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8040294	3001831	SCOP2B (2022-06-29)
G	SCOP2 Family	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8027936	4002070	SCOP2 (2022-06-29)
G	SCOP2 Superfamily	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8040315	3000797	SCOP2 (2022-06-29)
R	SCOP2B Superfamily	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8040315	3000797	SCOP2B (2022-06-29)
H	SCOP2 Family	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8027939	4002057	SCOP2 (2022-06-29)
H	SCOP2 Superfamily	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8040318	3000770	SCOP2 (2022-06-29)
S	SCOP2B Superfamily	Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8040318	3000770	SCOP2B (2022-06-29)
I	SCOP2 Family	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8027940	4002059	SCOP2 (2022-06-29)
I	SCOP2 Superfamily	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8040319	3000779	SCOP2 (2022-06-29)
T	SCOP2B Superfamily	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8040319	3000779	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	Cytochrome c	8036427	3000815	SCOP2B (2022-06-29)
B	SCOP2 Family	MPP-like	8027918	4002871	SCOP2 (2022-06-29)
B	SCOP2 Family	MPP-like	8027921	4002871	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	LuxS/MPP-like metallohydrolase	8040297	3001831	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	LuxS/MPP-like metallohydrolase	8040300	3001831	SCOP2 (2022-06-29)
M	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8040297	3001831	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	LuxS/MPP-like metallohydrolase	8040300	3001831	SCOP2B (2022-06-29)
C	SCOP2 Family	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8027920	4002216	SCOP2 (2022-06-29)
C	SCOP2 Family	Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8027923	4002208	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8040299	3000966	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Transmembrane di-heme cytochromes	8040302	3000517	SCOP2 (2022-06-29)
N	SCOP2B Superfamily	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8040299	3000966	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Transmembrane di-heme cytochromes	8040302	3000517	SCOP2B (2022-06-29)
D	SCOP2 Family	Cytochrome bc1 domain	8027925	4000656	SCOP2 (2022-06-29)
D	SCOP2 Family	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	8027926	4002056	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Cytochrome c	8040304	3000815	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	8040305	3000762	SCOP2 (2022-06-29)
O	SCOP2B Superfamily	Cytochrome c	8040304	3000815	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor	8040305	3000762	SCOP2B (2022-06-29)
E	SCOP2 Family	Rieske iron-sulfur protein (ISP)	8027928	4001667	SCOP2 (2022-06-29)
E	SCOP2 Family	ISP transmembrane anchor	8027929	4002051	SCOP2 (2022-06-29)
E	SCOP2 Superfamily	ISP domain	8040307	3000233	SCOP2 (2022-06-29)
E	SCOP2 Superfamily	ISP transmembrane anchor	8040308	3000753	SCOP2 (2022-06-29)
P	SCOP2B Superfamily	ISP transmembrane anchor	8040308	3000753	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	ISP domain	8040307	3000233	SCOP2B (2022-06-29)
F	SCOP2 Family	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8027933	4002082	SCOP2 (2022-06-29)
F	SCOP2 Superfamily	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8040312	3000806	SCOP2 (2022-06-29)
Q	SCOP2B Superfamily	Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8040312	3000806	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_M16_C	e3cx5A2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C	ECOD (1.6)
A	Peptidase_M16	e3cx5A1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
L	Peptidase_M16_C	e3cx5L2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C	ECOD (1.6)
L	Peptidase_M16	e3cx5L1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
G	UCR_14kD	e3cx5G1	A: alpha arrays	X: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_14kD	ECOD (1.6)
R	UCR_14kD	e3cx5R1	A: alpha arrays	X: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_14kD	ECOD (1.6)
H	UcrQ	e3cx5H1	A: extended segments	X: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UcrQ	ECOD (1.6)
S	UcrQ	e3cx5S1	A: extended segments	X: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UcrQ	ECOD (1.6)
I	UCR_UQCRX_QCR9	e3cx5I1	A: extended segments	X: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_UQCRX_QCR9	ECOD (1.6)
T	UCR_UQCRX_QCR9	e3cx5T1	A: extended segments	X: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_UQCRX_QCR9	ECOD (1.6)
J	V-set_8	e3cx5J1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
U	V-set_8	e3cx5U1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
K	V-set	e3cx5K1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
V	V-set	e3cx5V1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
W	Cytochrom_C_1	e3cx5W1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C_1	ECOD (1.6)
B	Peptidase_M16	e3cx5B1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
B	UNK_F_TYPE	e3cx5B2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: UNK_F_TYPE	ECOD (1.6)
M	Peptidase_M16	e3cx5M1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
M	UNK_F_TYPE	e3cx5M2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: UNK_F_TYPE	ECOD (1.6)
C	Cytochrom_B_C	e3cx5C1	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: Cytochrom_B_C	ECOD (1.6)
C	Cytochrome_B	e3cx5C2	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: Cytochrome_B	ECOD (1.6)
N	Cytochrom_B_C	e3cx5N1	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: Cytochrom_B_C	ECOD (1.6)
N	Cytochrome_B	e3cx5N2	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: Cytochrome_B	ECOD (1.6)
D	Cytochrom_C1_N	e3cx5D1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C1_N	ECOD (1.6)
D	Cytochrom_C1_C	e3cx5D2	A: extended segments	X: cytochrome c1 transmembrane anchor (From Topology)	H: cytochrome c1 transmembrane anchor (From Topology)	T: cytochrome c1 transmembrane anchor	F: Cytochrom_C1_C	ECOD (1.6)
O	Cytochrom_C1_N	e3cx5O1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C1_N	ECOD (1.6)
O	Cytochrom_C1_C	e3cx5O2	A: extended segments	X: cytochrome c1 transmembrane anchor (From Topology)	H: cytochrome c1 transmembrane anchor (From Topology)	T: cytochrome c1 transmembrane anchor	F: Cytochrom_C1_C	ECOD (1.6)
E	Rieske_cytochrome_bc1	e3cx5E1	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: Rieske_cytochrome_bc1	ECOD (1.6)
E	Rieske_6	e3cx5E3	A: few secondary structure elements	X: Trm112p-like (From Topology)	H: Trm112p-like (From Topology)	T: Trm112p-like	F: Rieske_6	ECOD (1.6)
E	UCR_TM	e3cx5E2	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: UCR_TM	ECOD (1.6)
P	Rieske_cytochrome_bc1	e3cx5P1	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: Rieske_cytochrome_bc1	ECOD (1.6)
P	Rieske_6	e3cx5P3	A: few secondary structure elements	X: Trm112p-like (From Topology)	H: Trm112p-like (From Topology)	T: Trm112p-like	F: Rieske_6	ECOD (1.6)
P	UCR_TM	e3cx5P2	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: UCR_TM	ECOD (1.6)
F	UCR_hinge	e3cx5F1	A: alpha bundles	X: cytochrome bc1 complex 11 kDa protein-like	H: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_hinge	ECOD (1.6)
Q	UCR_hinge	e3cx5Q1	A: alpha bundles	X: cytochrome bc1 complex 11 kDa protein-like	H: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_hinge	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
L	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
G	1.10.1090.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain F	CATH (4.3.0)
R	1.10.1090.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain F	CATH (4.3.0)
H	1.20.5.210	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 8	CATH (4.3.0)
S	1.20.5.210	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 8	CATH (4.3.0)
I	1.20.5.260	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 9	CATH (4.3.0)
T	1.20.5.260	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 9	CATH (4.3.0)
J	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
U	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
K	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
V	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
W	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
B	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
M	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
C	1.20.810.10	Mainly Alpha	Up-down Bundle	Cytochrome Bc1 Complex	Chain C	CATH (4.3.0)
N	1.20.810.10	Mainly Alpha	Up-down Bundle	Cytochrome Bc1 Complex	Chain C	CATH (4.3.0)
D	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
D	1.20.5.100	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome c1, transmembrane anchor, C-terminal	CATH (4.3.0)
O	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
O	1.20.5.100	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome c1, transmembrane anchor, C-terminal	CATH (4.3.0)
E	1.20.5.270	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Ubiquinol cytochrome reductase, transmembrane domain	CATH (4.3.0)
E	2.102.10.10	Mainly Beta	3-layer Sandwich	Rieske Iron-sulfur Protein	Rieske [2Fe-2S] iron-sulphur domain	CATH (4.3.0)
P	1.20.5.270	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Ubiquinol cytochrome reductase, transmembrane domain	CATH (4.3.0)
P	2.102.10.10	Mainly Beta	3-layer Sandwich	Rieske Iron-sulfur Protein	Rieske [2Fe-2S] iron-sulphur domain	CATH (4.3.0)
F	1.10.287.20	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Ubiquinol-cytochrome C reductase hinge domain	CATH (4.3.0)
Q	1.10.287.20	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Ubiquinol-cytochrome C reductase hinge domain	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
J, U	FV-FRAGMENT	VH	Mus musculus (house mouse)	IGHV3-602, IGHV3-601, IGHJ4*01	V-DOMAIN VH	IG	FV-HEAVY_KAPPA	IMGT (202445-0)
K, V	FV-FRAGMENT	V-KAPPA	Mus musculus (house mouse)	IGKV10-9403, IGKV10-9603, IGKV10-9404, IGKV10-9406, IGKV10-9604, IGKV10-9405, IGKV10-9408, IGKJ101	V-DOMAIN V-KAPPA	IG	FV-HEAVY_KAPPA	IMGT (202445-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
J, U	Heavy Chain	IGHV3	-	cytochrome b-c1 complex subunit rieske, mitochondrial	SAbDab (2024-11-15)
K, V	Light Chain	IGKV10	Kappa	cytochrome b-c1 complex subunit rieske, mitochondrial	SAbDab (2024-11-15)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, L	PF05193	Peptidase M16 inactive domain (Peptidase_M16_C)	Peptidase M16 inactive domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	Domain
A, L	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family
G, R	PF02271	Ubiquinol-cytochrome C reductase complex 14kD subunit (UCR_14kD)	Ubiquinol-cytochrome C reductase complex 14kD subunit	-	Family
H, S	PF02939	UcrQ family (UcrQ)	UcrQ family	-	Family
I, T	PF05365	Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like (UCR_UQCRX_QCR9)	Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like	-	Family
W	PF00034	Cytochrome c (Cytochrom_C)	Cytochrome c	The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, Pfam:PF06181, has now been merged into this family.	Domain
B, M	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family
C, N	PF00032	Cytochrome b(C-terminal)/b6/petD (Cytochrom_B_C)	Cytochrome b(C-terminal)/b6/petD	-	Domain
C, N	PF00033	Cytochrome b/b6/petB (Cytochrome_B)	Cytochrome b/b6/petB	-	Domain
D, O	PF02167	Cytochrome C1 family (Cytochrom_C1)	Cytochrome C1 family	-	Family
E, P	PF02921	Ubiquinol cytochrome reductase transmembrane region (UCR_TM)	Ubiquinol cytochrome reductase transmembrane region	-	Family
E, P	PF00355	Rieske [2Fe-2S] domain (Rieske)	Rieske [2Fe-2S] domain	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in ...	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilises the protein [4].	Domain
F, Q	PF02320	Ubiquinol-cytochrome C reductase hinge protein (UCR_hinge)	Ubiquinol-cytochrome C reductase hinge protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, L	Cytochrome b-c1 complex subunit 1, mitochondrial	peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity endopeptidase activity cation binding ion binding binding metal ion binding small molecule binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process mitochondrial ATP synthesis coupled electron transport protein localization establishment of protein localization cellular localization protein targeting protein processing involved in protein targeting to mitochondrion protein maturation proteolysis cellular macromolecule localization protein metabolic process primary metabolic process gene expression macromolecule biosynthetic process establishment of protein localization to organelle mitochondrial protein processing biosynthetic process macromolecule localization protein localization to organelle protein localization to mitochondrion protein targeting to mitochondrion protein processing macromolecule metabolic process establishment of protein localization to mitochondrion	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane
G, R	Cytochrome b-c1 complex subunit 7	-	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process mitochondrial ATP synthesis coupled electron transport cytochrome complex assembly protein-containing complex organization mitochondrial respirasome assembly mitochondrial respiratory chain complex III assembly cellular component organization cellular component biogenesis organelle organization cellular component assembly respiratory chain complex III assembly mitochondrial respiratory chain complex assembly protein-containing complex assembly cellular component organization or biogenesis mitochondrion organization	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane side of membrane lumenal side of membrane matrix side of mitochondrial inner membrane
H, S	Cytochrome b-c1 complex subunit 8	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane
I, T	Cytochrome b-c1 complex subunit 9	-	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process mitochondrial ATP synthesis coupled electron transport cytochrome complex assembly protein-containing complex organization mitochondrial respirasome assembly mitochondrial respiratory chain complex III assembly cellular component organization cellular component biogenesis organelle organization cellular component assembly respiratory chain complex III assembly mitochondrial respiratory chain complex assembly protein-containing complex assembly cellular component organization or biogenesis mitochondrion organization	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane
J, U	HEAVY CHAIN (VH) OF FV-FRAGMENT	-	-	-
K, V	LIGHT CHAIN (VL) OF FV-FRAGMENT	-	-	-
W	Cytochrome c iso-1	ion binding binding anion binding phosphatidylglycerol binding phospholipid binding lipid binding cardiolipin binding small molecule binding organic cyclic compound binding tetrapyrrole binding heme binding electron transfer activity cation binding metal ion binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport mitochondrial electron transport, ubiquinol to cytochrome c	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial intermembrane space membrane-enclosed lumen intracellular organelle lumen organelle envelope lumen organelle envelope organelle lumen membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial intermembrane space membrane-enclosed lumen intracellular organelle lumen organelle envelope lumen organelle envelope organelle lumen mitochondrial envelope
B, M	Cytochrome b-c1 complex subunit 2, mitochondrial	peptidase activity catalytic activity, acting on a protein metalloendopeptidase activity hydrolase activity metallopeptidase activity catalytic activity endopeptidase activity cation binding ion binding binding metal ion binding small molecule binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process mitochondrial ATP synthesis coupled electron transport proteolysis primary metabolic process protein metabolic process macromolecule metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane mitochondrial crista
C, N	CYTOCHROME B	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane
D, O	Cytochrome c1, heme protein, mitochondrial	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane cytosol mitochondrial intermembrane space membrane-enclosed lumen intracellular organelle lumen organelle envelope lumen organelle lumen
E, P	Cytochrome b-c1 complex subunit Rieske, mitochondrial	oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity transmembrane transporter activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane
F, Q	Cytochrome b-c1 complex subunit 6	-	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane nucleus membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen mitochondrial intermembrane space organelle envelope lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, L	IPR007863	Peptidase M16, C-terminal	Domain
A, L	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
A, L	IPR050361	Mitochondrial Processing Peptidase/Ubiquinol-cytochrome c Reductase Complex	Family
A, L	IPR011765	Peptidase M16, N-terminal	Domain
G, R	IPR003197	Cytochrome b-c1 complex subunit 7	Family
G, R	IPR036544	Cytochrome b-c1 complex subunit 7 superfamily	Homologous Superfamily
H, S	IPR004205	Cytochrome b-c1 complex subunit 8	Family
H, S	IPR036642	Cytochrome b-c1 complex subunit 8 superfamily	Homologous Superfamily
I, T	IPR008027	Cytochrome b-c1 complex subunit 9	Family
I, T	IPR036656	Cytochrome b-c1 complex subunit 9 superfamily	Homologous Superfamily
W	IPR036909	Cytochrome c-like domain superfamily	Homologous Superfamily
W	IPR009056	Cytochrome c-like domain	Domain
W	IPR002327	Cytochrome c, class IA/ IB	Family
B, M	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
B, M	IPR050361	Mitochondrial Processing Peptidase/Ubiquinol-cytochrome c Reductase Complex	Family
B, M	IPR011765	Peptidase M16, N-terminal	Domain
B, M	IPR001431	Peptidase M16, zinc-binding site	Binding Site
C, N	IPR036150	Cytochrome b/b6, C-terminal domain superfamily	Homologous Superfamily
C, N	IPR027387	Cytochrome b/b6-like domain superfamily	Homologous Superfamily
C, N	IPR048260	Cytochrome b/b6, C-terminal domain, eukaryotic/bacterial	Domain
C, N	IPR016174	Di-haem cytochrome, transmembrane	Homologous Superfamily
C, N	IPR005798	Cytochrome b/b6, C-terminal	Domain
C, N	IPR048259	Cytochrome b/b6, N-terminal domain, eukaryotic/bacterial	Domain
C, N	IPR030689	Cytochrome b	Family
C, N	IPR005797	Cytochrome b/b6, N-terminal domain	Domain
D, O	IPR036909	Cytochrome c-like domain superfamily	Homologous Superfamily
D, O	IPR002326	Cytochrome c1	Family
D, O	IPR009056	Cytochrome c-like domain	Domain
D, O	IPR021157	Cytochrome c1, transmembrane anchor, C-terminal	Homologous Superfamily
E, P	IPR036922	Rieske [2Fe-2S] iron-sulphur domain superfamily	Homologous Superfamily
E, P	IPR014349	Rieske iron-sulphur protein	Family
E, P	IPR004192	Cytochrome b-c1 complex subunit Rieske, transmembrane domain	Domain
E, P	IPR017941	Rieske [2Fe-2S] iron-sulphur domain	Domain
E, P	IPR005805	Rieske iron-sulphur protein, C-terminal	Domain
E, P	IPR037008	Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily	Homologous Superfamily
E, P	IPR006317	Ubiquinol-cytochrome c reductase, iron-sulphur subunit	Domain
F, Q	IPR023184	Ubiquinol-cytochrome C reductase hinge domain	Domain
F, Q	IPR036811	Ubiquinol-cytochrome C reductase hinge domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, L, M, N, O, P, Q, R, S, T	OPM	Transmembrane	Alpha-helical polytopic	Electron transport chain complex III (bc1 and b6f) superfamily	Cytochrome bc1 and b6f complexes