3JQC

Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-6-bromo-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (JU2)


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilySDR-like 8099562 3000038 SCOP2B (2022-06-29)
BSCOP2B SuperfamilySDR-like 8099562 3000038 SCOP2B (2022-06-29)
CSCOP2 FamilyShort-chain dehydrogenases/reductases, SDR 8099561 4000029 SCOP2 (2022-06-29)
CSCOP2 SuperfamilySDR-like 8099562 3000038 SCOP2 (2022-06-29)
DSCOP2B SuperfamilySDR-like 8099562 3000038 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
Aadh_short_C2e3jqcA1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)
Badh_short_C2e3jqcB1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)
Cadh_short_C2e3jqcC1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)
Dadh_short_C2e3jqcD1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: adh_short_C2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF13561Enoyl-(Acyl carrier protein) reductase (adh_short_C2)Enoyl-(Acyl carrier protein) reductaseThis domain is found in Enoyl-(Acyl carrier protein) reductases.Domain