Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyGrowth factor receptor domain-like 8038763 3000398 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyL domain-like 8038760 3001010 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyL domain-like 8038760 3001010 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyGrowth factor receptor domain-like 8038763 3000398 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyEGF/Laminin-like 8033508 3000412 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyEGF/Laminin-like 8033508 3000412 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARecep_L_domaine3njpA1 A: beta duplicates or obligate multimersX: Single-stranded right-handed beta-helixH: Leucine-rich repeats (From Topology)T: Leucine-rich repeatsF: Recep_L_domainECOD (1.6)
AGF_recep_IVe3njpA4 A: few secondary structure elementsX: EGF-likeH: Growth factor receptor domain (From Topology)T: Growth factor receptor domainF: GF_recep_IVECOD (1.6)
AFurin-likee3njpA3 A: few secondary structure elementsX: EGF-likeH: Growth factor receptor domain (From Topology)T: Growth factor receptor domainF: Furin-likeECOD (1.6)
BRecep_L_domaine3njpB1 A: beta duplicates or obligate multimersX: Single-stranded right-handed beta-helixH: Leucine-rich repeats (From Topology)T: Leucine-rich repeatsF: Recep_L_domainECOD (1.6)
BGF_recep_IVe3njpB4 A: few secondary structure elementsX: EGF-likeH: Growth factor receptor domain (From Topology)T: Growth factor receptor domainF: GF_recep_IVECOD (1.6)
BFurin-likee3njpB5 A: few secondary structure elementsX: EGF-likeH: Growth factor receptor domain (From Topology)T: Growth factor receptor domainF: Furin-likeECOD (1.6)
CEGFe3njpC1 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: EGFECOD (1.6)
DEGFe3njpD1 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: EGFECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00757Furin-like cysteine rich region (Furin-like)Furin-like cysteine rich region- Domain
A, B
PF01030Receptor L domain (Recep_L_domain)Receptor L domain- Repeat
A, B
PF14843Growth factor receptor domain IV (GF_recep_IV)Growth factor receptor domain IVThis is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (Pfam:PF00757) regulates the binding of ligands to the receptor L domains (Pfam:PF01030) [1].Domain
C, D
PF00008EGF-like domain (EGF)EGF-like domainThere is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is t ...There is no clear separation between noise and signal. Pfam:PF00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Epidermal growth factor receptor
C, D
Epidermal growth factor

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR016245Tyrosine protein kinase, EGF/ERB/XmrK receptorFamily
A, B
IPR020635Tyrosine-protein kinase, catalytic domainDomain
A, B
IPR000719Protein kinase domainDomain
A, B
IPR032778Growth factor receptor domain 4Domain
A, B
IPR006212Furin-like repeatRepeat
A, B
IPR017441Protein kinase, ATP binding siteBinding Site
A, B
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainDomain
A, B
IPR009030Growth factor receptor cysteine-rich domain superfamilyHomologous Superfamily
A, B
IPR008266Tyrosine-protein kinase, active siteActive Site
A, B
IPR036941Receptor L-domain superfamilyHomologous Superfamily
A, B
IPR049328Epidermal growth factor receptor-like, transmembrane-juxtamembrane segmentDomain
A, B
IPR000494Receptor L-domainDomain
A, B
IPR011009Protein kinase-like domain superfamilyHomologous Superfamily
A, B
IPR006211Furin-like cysteine-rich domainDomain
A, B
IPR050122Receptor Tyrosine KinaseFamily
C, D
IPR018097EGF-like calcium-binding, conserved siteConserved Site
C, D
IPR049883NOTCH1 EGF-like calcium-binding domainDomain
C, D
IPR000033LDLR class B repeatRepeat
C, D
IPR001881EGF-like calcium-binding domainDomain
C, D
IPR011042Six-bladed beta-propeller, TolB-likeHomologous Superfamily
C, D
IPR000742EGF-like domainDomain
C, D
IPR050778Cueball/EGF/LRP/NidogenFamily
C, D
IPR009030Growth factor receptor cysteine-rich domain superfamilyHomologous Superfamily
C, D
IPR016317Pro-epidermal growth factorFamily
C, D
IPR000152EGF-type aspartate/asparagine hydroxylation sitePTM

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B
PharosP00533
C, D
PharosP01133