Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyCobalamin (vitamin B12)-binding domain 8044101 3001260 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyCobalamin (vitamin B12)-dependent enzymes 8043843 3000609 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCobalamin (vitamin B12)-dependent enzymes 8043845 3000609 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCobalamin (vitamin B12)-binding domain 8044102 3001260 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMM_CoA_mutasee3reqA1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MM_CoA_mutaseECOD (1.6)
AB12-bindinge3reqA2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: CheY-likeF: B12-bindingECOD (1.6)
BMM_CoA_mutasee3reqB1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: MM_CoA_mutaseECOD (1.6)
BmmCoA_mut_betae3reqB2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: CheY-likeF: mmCoA_mut_betaECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.20.20.240 Alpha Beta Alpha-Beta Barrel TIM Barrel Methylmalonyl-CoA mutaseCATH (4.3.0)
A3.40.50.280 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Cobalamin-binding domainCATH (4.3.0)
B3.20.20.240 Alpha Beta Alpha-Beta Barrel TIM Barrel Methylmalonyl-CoA mutaseCATH (4.3.0)
B3.40.50.280 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Cobalamin-binding domainCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF02310B12 binding domain (B12-binding)B12 binding domainThis domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, ...This domain binds to B12 (adenosylcobamide)[1-3], it is found in several enzymes, such as glutamate mutase Swiss:Q05488, methionine synthase Swiss:Q99707 and methylmalonyl-CoA mutase Swiss:P22033. It contains a conserved DxHxxGx(41)SxVx(26)GG motif, which is important for B12 binding [2].
Domain
PF01642Methylmalonyl-CoA mutase (MM_CoA_mutase)Methylmalonyl-CoA mutase- Family
PF01642Methylmalonyl-CoA mutase (MM_CoA_mutase)Methylmalonyl-CoA mutase- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
METHYLMALONYL-COA MUTASE
METHYLMALONYL-COA MUTASE