Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2 FamilyViral cysteine protease of trypsin fold, (M)Pro-like 8076458 4002259 SCOP2 (2022-06-29)
ASCOP2 SuperfamilyTrypsin-like serine proteases 8076459 3000114 SCOP2 (2022-06-29)
BSCOP2B SuperfamilyTrypsin-like serine proteases 8076459 3000114 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APeptidase_C30_Ne3tloA1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrelF: Peptidase_C30_NECOD (1.6)
APeptidase_C30_Ce3tloA2 A: alpha arraysX: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)H: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)T: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainF: Peptidase_C30_CECOD (1.6)
BPeptidase_C30_Ne3tloB1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: FMN-binding split barrelF: Peptidase_C30_NECOD (1.6)
BPeptidase_C30_Ce3tloB2 A: alpha arraysX: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)H: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domain (From Topology)T: Coronavirus main proteinase (3Cl-pro, putative coronavirus nsp2) C-terminal domainF: Peptidase_C30_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF05409Coronavirus endopeptidase C30 (Peptidase_C30)Coronavirus endopeptidase C30- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
3C-like proteinase

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR043611Coronavirus replicase NSP3, C-terminalDomain
A, B
IPR038123Non-structural protein NSP4, C-terminal superfamily, coronavirusHomologous Superfamily
A, B
IPR047566Coronavirus replicase NSP3, Y domainDomain
A, B
IPR043178Papain-like protease, thumb domain superfamily, coronavirusHomologous Superfamily
A, B
IPR043612Non-structural protein NSP4, N-terminal, coronavirusDomain
A, B
IPR044353NSP3, second ubiquitin-like (Ubl) domain, coronavirusDomain
A, B
IPR009003Peptidase S1, PA clanHomologous Superfamily
A, B
IPR013016Peptidase C16, coronavirusDomain
A, B
IPR037204Non-structural protein NSP7 superfamily, coronavirusHomologous Superfamily
A, B
IPR044357NSP3, first ubiquitin-like (Ubl) domain, coronavirusDomain
A, B
IPR046443NSP1, globular domain, alpha/betacoronavirusDomain
A, B
IPR043610Non-structural protein 6, coronavirusDomain
A, B
IPR043477Peptidase C30, domain 3, coronavirusHomologous Superfamily
A, B
IPR018995RNA synthesis protein NSP10, coronavirusDomain
A, B
IPR011050Pectin lyase fold/virulence factorHomologous Superfamily
A, B
IPR043615Nonstructural protein 2, N-terminal domain, coronavirusDomain
A, B
IPR044369Non-structural protein 6, alphacoronavirusDomain
A, B
IPR014822Non-structural protein NSP9, coronavirusDomain
A, B
IPR037230Non-structural protein NSP8 superfamily, coronavirusHomologous Superfamily
A, B
IPR014828Non-structural protein NSP7, coronavirusDomain
A, B
IPR032505Non-structural protein NSP4, C-terminal, coronavirusDomain
A, B
IPR014829Non-structural protein NSP8, coronavirusDomain
A, B
IPR036499Non-structural protein NSP9 superfamily, coronavirusHomologous Superfamily
A, B
IPR002589Macro domainDomain
A, B
IPR008740Peptidase C30, coronavirusDomain
A, B
IPR036333RNA synthesis protein NSP10 superfamily, coronavirusHomologous Superfamily
A, B
IPR047573Non-structural protein 2, middle domain, coronavirusDomain
A, B
IPR049894Coronavirus NSP3, 3Ecto domainDomain
A, B
IPR044309Non-structural protein 5, alphacoronavirusDomain
A, B
IPR043472Macro domain-likeHomologous Superfamily
A, B
IPR044371Non-structural protein 3, X-domain-likeDomain
A, B
IPR043613Non-structural protein 2, C-terminal domain, coronavirusDomain
A, B
IPR044385Nonstructural protein 2, HCoV-229E-likeDomain
A, B
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily