Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
CSCOP2B SuperfamilyInsulin-like 8038024 3000307 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyInsulin-like 8038024 3000307 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyInsulin-like 8038024 3000307 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyInsulin-like 8038024 3000307 SCOP2B (2022-06-29)
KSCOP2B SuperfamilyInsulin-like 8038024 3000307 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyInsulin-like 8038024 3000307 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
DInsuline4ajxD1 A: few secondary structure elementsX: Insulin-like (From Topology)H: Insulin-like (From Topology)T: Insulin-likeF: InsulinECOD (1.6)
FInsuline4ajxF1 A: few secondary structure elementsX: Insulin-like (From Topology)H: Insulin-like (From Topology)T: Insulin-likeF: InsulinECOD (1.6)
HInsuline4ajxH1 A: few secondary structure elementsX: Insulin-like (From Topology)H: Insulin-like (From Topology)T: Insulin-likeF: InsulinECOD (1.6)
LInsuline4ajxL1 A: few secondary structure elementsX: Insulin-like (From Topology)H: Insulin-like (From Topology)T: Insulin-likeF: InsulinECOD (1.6)
JInsuline4ajxJ1 A: few secondary structure elementsX: Insulin-like (From Topology)H: Insulin-like (From Topology)T: Insulin-likeF: InsulinECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B, D, F, H, J
PF00049Insulin/IGF/Relaxin family (Insulin)Insulin/IGF/Relaxin familySuperfamily includes insulins; relaxins; insulin-like growth factor; and bombyxin. All are secreted regulatory hormones. Disulfide rich, all-alpha fold. Alignment includes B chain, linker (which is processed out of the final product), and A chain.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C, E, G, I
INSULIN
B, D, F, H, J
INSULIN

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, C, E, G, I
IPR004825InsulinFamily
A, C, E, G, I
IPR022353Insulin, conserved siteConserved Site
A, C, E, G, I
IPR036438Insulin-like superfamilyHomologous Superfamily
A, C, E, G, I
IPR022352Insulin familyFamily
A, C, E, G, I
IPR016179Insulin-likeDomain
B, D, F, H, J
IPR004825InsulinFamily
B, D, F, H, J
IPR022353Insulin, conserved siteConserved Site
B, D, F, H, J
IPR036438Insulin-like superfamilyHomologous Superfamily
B, D, F, H, J
IPR022352Insulin familyFamily
B, D, F, H, J
IPR016179Insulin-likeDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, C, E, G, I
PharosP01308
B, D, F, H, J
PharosP01308