4B3H
Crystal structure of Mycobacterium tuberculosis fatty acid beta- oxidation complex
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C | d4b3hc1 | Alpha and beta proteins (a/b) | Thiolase-like | Thiolase-like | automated matches | automated matches | (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], | SCOPe (2.08) |
D | d4b3hd1 | Alpha and beta proteins (a/b) | Thiolase-like | Thiolase-like | automated matches | automated matches | (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
B | 3HCDH | e4b3hB11 | A: alpha arrays | X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | T: 6-phosphogluconate dehydrogenase C-terminal domain-like | F: 3HCDH | ECOD (1.6) |
B | UNK_F_TYPE | e4b3hB12 | A: alpha arrays | X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | T: 6-phosphogluconate dehydrogenase C-terminal domain-like | F: UNK_F_TYPE | ECOD (1.6) |
B | 3HCDH_N | e4b3hB9 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: 3HCDH_N | ECOD (1.6) |
B | ECH_1 | e4b3hB10 | A: a/b three-layered sandwiches | X: ClpP/crotonase (From Topology) | H: ClpP/crotonase (From Topology) | T: ClpP/crotonase | F: ECH_1 | ECOD (1.6) |
A | 3HCDH | e4b3hA11 | A: alpha arrays | X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | T: 6-phosphogluconate dehydrogenase C-terminal domain-like | F: 3HCDH | ECOD (1.6) |
A | UNK_F_TYPE | e4b3hA12 | A: alpha arrays | X: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology) | T: 6-phosphogluconate dehydrogenase C-terminal domain-like | F: UNK_F_TYPE | ECOD (1.6) |
A | 3HCDH_N | e4b3hA9 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: NAD(P)-binding Rossmann-fold domains | F: 3HCDH_N | ECOD (1.6) |
A | ECH_1 | e4b3hA10 | A: a/b three-layered sandwiches | X: ClpP/crotonase (From Topology) | H: ClpP/crotonase (From Topology) | T: ClpP/crotonase | F: ECH_1 | ECOD (1.6) |
C | Thiolase_C | e4b3hC2 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Thiolase_C | ECOD (1.6) |
C | Thiolase_N | e4b3hC1 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Thiolase_N | ECOD (1.6) |
D | Thiolase_C | e4b3hD2 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Thiolase_C | ECOD (1.6) |
D | Thiolase_N | e4b3hD1 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: Thiolase_N | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
B | 3.90.226.10 | Alpha Beta | Alpha-Beta Complex | 2-enoyl-CoA Hydratase | Chain A, domain 1 | CATH (4.3.0) |
B | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
B | 1.10.1040.50 | Mainly Alpha | Orthogonal Bundle | N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase | domain 2 | CATH (4.3.0) |
A | 3.90.226.10 | Alpha Beta | Alpha-Beta Complex | 2-enoyl-CoA Hydratase | Chain A, domain 1 | CATH (4.3.0) |
A | 3.40.50.720 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | CATH (4.3.0) |
A | 1.10.1040.50 | Mainly Alpha | Orthogonal Bundle | N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase | domain 2 | CATH (4.3.0) |
C | 3.40.47.10 | Alpha Beta | 3-Layer(aba) Sandwich | Peroxisomal Thiolase | Chain A, domain 1 | CATH (4.3.0) |
D | 3.40.47.10 | Alpha Beta | 3-Layer(aba) Sandwich | Peroxisomal Thiolase | Chain A, domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02737 | 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain (3HCDH_N) | 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain | This family also includes lambda crystallin. | Domain | |
PF00725 | 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain (3HCDH) | 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain | This family also includes lambda crystallin. Some proteins include two copies of this domain. | Domain | |
PF00378 | Enoyl-CoA hydratase/isomerase (ECH_1) | Enoyl-CoA hydratase/isomerase | This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. | Domain | |
PF02803 | Thiolase, C-terminal domain (Thiolase_C) | Thiolase, C-terminal domain | Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase. | Domain | |
PF00108 | Thiolase, N-terminal domain (Thiolase_N) | Thiolase, N-terminal domain | Thiolase is reported to be structurally related to beta-ketoacyl synthase (Pfam:PF00109), and also chalcone synthase. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR001753 | Enoyl-CoA hydratase/isomerase | Family | |
IPR029045 | ClpP/crotonase-like domain superfamily | Homologous Superfamily | |
IPR050136 | Fatty acid oxidation complex subunit alpha | Family | |
IPR008927 | 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily | Homologous Superfamily | |
IPR006108 | 3-hydroxyacyl-CoA dehydrogenase, C-terminal | Domain | |
IPR036291 | NAD(P)-binding domain superfamily | Homologous Superfamily | |
IPR006176 | 3-hydroxyacyl-CoA dehydrogenase, NAD binding | Domain | |
IPR016039 | Thiolase-like | Homologous Superfamily | |
IPR020617 | Thiolase, C-terminal | Domain | |
IPR020616 | Thiolase, N-terminal | Domain | |
IPR020613 | Thiolase, conserved site | Conserved Site | |
IPR020610 | Thiolase, active site | Active Site | |
IPR020615 | Thiolase, acyl-enzyme intermediate active site | Active Site | |
IPR002155 | Thiolase | Family |