4BV8

Crystal structure of the apo form of mouse Mu-crystallin.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ornithine cyclodeaminase-like	8098186	3000041	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ornithine cyclodeaminase-like	8098186	3000041	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	OCD_Mu_crystall_N	e4bv8A2	A: a+b two layers	X: Ornithine cyclodeaminase-like enzymes dimerization domain (From Topology)	H: Ornithine cyclodeaminase-like enzymes dimerization domain (From Topology)	T: Ornithine cyclodeaminase-like enzymes dimerization domain	F: OCD_Mu_crystall_N	ECOD (1.6)
A	OCD_Mu_crystall_C	e4bv8A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: OCD_Mu_crystall_C	ECOD (1.6)
B	OCD_Mu_crystall_N	e4bv8B2	A: a+b two layers	X: Ornithine cyclodeaminase-like enzymes dimerization domain (From Topology)	H: Ornithine cyclodeaminase-like enzymes dimerization domain (From Topology)	T: Ornithine cyclodeaminase-like enzymes dimerization domain	F: OCD_Mu_crystall_N	ECOD (1.6)
B	OCD_Mu_crystall_C	e4bv8B1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NAD(P)-binding Rossmann-fold domains	F: OCD_Mu_crystall_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1780.10	Alpha Beta	2-Layer Sandwich	ornithine cyclodeaminase, domain 1	ornithine cyclodeaminase, domain 1	CATH (4.3.0)
A	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)
B	3.30.1780.10	Alpha Beta	2-Layer Sandwich	ornithine cyclodeaminase, domain 1	ornithine cyclodeaminase, domain 1	CATH (4.3.0)
B	3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02423	Ornithine cyclodeaminase/mu-crystallin family (OCD_Mu_crystall)	Ornithine cyclodeaminase/mu-crystallin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	THIOMORPHOLINE-CARBOXYLATE DEHYDROGENASE	transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding NADP binding small molecule binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding NADP binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity thyroid hormone binding hormone binding oxidoreductase activity thiomorpholine-carboxylate dehydrogenase activity oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on the CH-NH group of donors catalytic activity	multicellular organismal process system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus thyroid hormone transport localization transport regulation of hormone levels biological regulation hormone transport regulation of biological quality establishment of localization multicellular organismal process system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus thyroid hormone transport localization transport regulation of hormone levels biological regulation hormone transport regulation of biological quality establishment of localization organic hydroxy compound metabolic process cellular metabolic process hormone metabolic process cellular modified amino acid metabolic process thyroid hormone metabolic process phenol-containing compound metabolic process metabolic process cellular process mitochondrial transport regulation of cellular process cellular biosynthetic process negative regulation of biological process RNA metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription regulation of biological process negative regulation of transcription by RNA polymerase II negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR023401	Ornithine cyclodeaminase, N-terminal	Homologous Superfamily
A, B	IPR036291	NAD(P)-binding domain superfamily	Homologous Superfamily
A, B	IPR003462	Ornithine cyclodeaminase/mu-crystallin	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.