4CQK

Crystal structure of ligand-bound NaD1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D	d4cqkd_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
F	d4cqkf_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
I	d4cqki_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
J	d4cqkj_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
K	d4cqkk_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
L	d4cqkl_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
M	d4cqkm_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
A	d4cqka_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
B	d4cqkb_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
C	d4cqkc_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
E	d4cqke_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
G	d4cqkg_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
H	d4cqkh_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)
N	d4cqkn_	Small proteins	Knottins (small inhibitors, toxins, lectins)	Scorpion toxin-like	Plant defensins	Floral defensin 1	(Nicotiana alata ) [TaxId: 4087 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Scorpion toxin-like	8078335	3000309	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	Gamma-thionin	e4cqkD1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
F	Gamma-thionin	e4cqkF1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
I	Gamma-thionin	e4cqkI1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
J	Gamma-thionin	e4cqkJ1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
K	Gamma-thionin	e4cqkK1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
L	Gamma-thionin	e4cqkL1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
M	Gamma-thionin	e4cqkM1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
A	Gamma-thionin	e4cqkA1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
B	Gamma-thionin	e4cqkB1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
C	Gamma-thionin	e4cqkC1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
E	Gamma-thionin	e4cqkE1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
G	Gamma-thionin	e4cqkG1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
H	Gamma-thionin	e4cqkH1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)
N	Gamma-thionin	e4cqkN1	A: few secondary structure elements	X: omega toxin-like	H: omega toxin-related	T: Scorpion toxin-like	F: Gamma-thionin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
F	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
I	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
J	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
K	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
L	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
M	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
A	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
B	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
C	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
E	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
G	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
H	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)
N	3.30.30.10	Alpha Beta	2-Layer Sandwich	Defensin A-like	Knottin, scorpion toxin-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	PF00304	Gamma-thionin family (Gamma-thionin)	Gamma-thionin family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	FLOWER-SPECIFIC DEFENSIN	-	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to fungus defense response to other organism response to stress response to external biotic stimulus response to fungus cellular process disruption of cell in another organism disruption of anatomical structure in another organism biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to fungus defense response to other organism response to stress response to external biotic stimulus response to fungus cellular process disruption of cell in another organism disruption of anatomical structure in another organism killing of cells of another organism cell killing	cellular anatomical structure extracellular region membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle vacuole cytoplasm intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR036574	Knottin, scorpion toxin-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR008176	Defensin, plant	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	IPR003614	Knottin, scorpion toxin-like	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N	OPM	Monotopic/peripheral	Alpha + Beta monotopic/peripheral	Scorpion toxin-like knottin	Plant defensins

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.