4D0O

AKAP13 (AKAP-Lbc) DH domain

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	DBL homology domain (DH-domain)	8085005	3000793	SCOP2B (2022-06-29)
A	SCOP2 Family	DBL homology domain (DH-domain)	8085004	4001108	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DBL homology domain (DH-domain)	8085005	3000793	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	RhoGEF	e4d0oB1	A: alpha bundles	X: DH domain-like	H: DBL homology domain (DH-domain) (From Topology)	T: DBL homology domain (DH-domain)	F: RhoGEF	ECOD (1.6)
A	RhoGEF	e4d0oA1	A: alpha bundles	X: DH domain-like	H: DBL homology domain (DH-domain) (From Topology)	T: DBL homology domain (DH-domain)	F: RhoGEF	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.900.10	Mainly Alpha	Up-down Bundle	Dbl Homology Domain	Chain A	CATH (4.3.0)
A	1.20.900.10	Mainly Alpha	Up-down Bundle	Dbl Homology Domain	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00621	RhoGEF domain (RhoGEF)	RhoGEF domain	Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	A-KINASE ANCHOR PROTEIN 13	small GTPase binding protein binding binding enzyme binding GTPase binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity molecular adaptor activity MAP-kinase scaffold activity protein-macromolecule adaptor activity signaling adaptor activity small GTPase binding protein binding binding enzyme binding GTPase binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity molecular adaptor activity MAP-kinase scaffold activity protein-macromolecule adaptor activity signaling adaptor activity protein kinase A binding cation binding ion binding metal ion binding small molecule binding	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction cellular process positive regulation of signaling heart process adenylate cyclase-activating adrenergic receptor signaling pathway adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process system process adenylate cyclase-activating G protein-coupled receptor signaling pathway circulatory system process adrenergic receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway involved in heart process skeletal system development bone development cellular developmental process cardiac muscle tissue development cardiac muscle cell differentiation muscle cell differentiation tissue development cardiocyte differentiation striated muscle tissue development muscle structure development cell differentiation striated muscle cell differentiation muscle tissue development small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction Rho protein signal transduction regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction positive regulation of small GTPase mediated signal transduction regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process cellular component assembly involved in morphogenesis cell development membraneless organelle assembly cellular component organization cellular component biogenesis striated muscle cell development cellular anatomical entity morphogenesis cellular component assembly muscle cell development sarcomere organization actin filament-based process cellular component organization or biogenesis actomyosin structure organization actin cytoskeleton organization organelle assembly regulation of organelle organization anatomical structure morphogenesis myofibril assembly organelle organization regulation of sarcomere organization regulation of actomyosin structure organization anatomical structure formation involved in morphogenesis regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization	cellular anatomical structure membrane cell periphery cell cortex intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001849	Pleckstrin homology domain	Domain
A, B	IPR000219	Dbl homology (DH) domain	Domain
A, B	IPR018459	RII binding domain	Domain
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Domain
A, B	IPR041020	ARHGEF1-like, PH domain	Domain
A, B	IPR051632	Rho guanine nucleotide exchange factor	Family
A, B	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A, B	IPR046349	C1-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q12802	renal cell carcinoma papillary renal cell carcinoma prostate cancer chromophobe renal cell carcinoma sarcomatoid renal cell carcinoma esophageal cancer idiopathic pulmonary fibrosis collecting duct carcinoma non-small cell lung carcinoma ovarian cancer pituitary cancer astrocytic tumor renal carcinoma Conventional (Clear Cell) Renal Cell Carcinoma glioblastoma renal cell carcinoma papillary renal cell carcinoma prostate cancer chromophobe renal cell carcinoma sarcomatoid renal cell carcinoma esophageal cancer idiopathic pulmonary fibrosis collecting duct carcinoma non-small cell lung carcinoma ovarian cancer pituitary cancer astrocytic tumor renal carcinoma Conventional (Clear Cell) Renal Cell Carcinoma glioblastoma lung adenocarcinoma malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma Pick disease primitive neuroectodermal tumor atypical teratoid rhabdoid tumor clear cell renal carcinoma subependymal giant cell astrocytoma lung cancer malignant glioma neoplasm of esophagus osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia pilocytic astrocytoma progressive supranuclear palsy cancer psoriasis rheumatoid arthritis Gaucher disease large cell medulloblastoma lung carcinoma malignant pancreatic neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.