Annotations: 4DVG

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4dvga_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	automated matches	(Entamoeba histolytica ) [TaxId: 5759 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ras	e4dvgA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)
B	Drf_GBD	e4dvgB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Drf_GBD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain
B	PF06367	Diaphanous FH3 Domain (Drf_FH3)	Diaphanous FH3 Domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Rho-like small GTPase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding organic cyclic compound binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	localization import into cell transport phagocytosis cellular process endocytosis establishment of localization vesicle-mediated transport protein localization cellular localization protein localization to phagocytic vesicle protein localization to organelle cellular macromolecule localization macromolecule localization localization import into cell transport phagocytosis cellular process endocytosis establishment of localization vesicle-mediated transport protein localization cellular localization protein localization to phagocytic vesicle protein localization to organelle cellular macromolecule localization macromolecule localization regulation of localization positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization positive regulation of biological process cellular component organization positive regulation of endocytosis cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of biological process regulation of transport biological regulation regulation of phagocytosis regulation of vesicle-mediated transport positive regulation of phagocytosis positive regulation of transport cellular response to stimulus small GTPase-mediated signal transduction response to stimulus signaling intracellular signal transduction cell communication intracellular signaling cassette signal transduction biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction	intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle cytoplasmic vesicle cytoplasm vesicle intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle cytoplasmic vesicle cytoplasm vesicle endocytic vesicle phagocytic cup cell periphery plasma membrane membrane cell projection
B	Diaphanous protein	small GTPase binding protein binding binding enzyme binding GTPase binding cytoskeletal protein binding actin binding	cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular process cellular component organization or biogenesis actin nucleation supramolecular fiber organization cytoskeleton organization protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization cellular component organization organelle organization actin cytoskeleton organization actin filament organization actin filament-based process cellular process cellular component organization or biogenesis actin nucleation supramolecular fiber organization cytoskeleton organization protein polymerization actin polymerization or depolymerization actin filament polymerization protein-containing complex organization cellular component biogenesis cellular component assembly protein-containing complex assembly	polymeric cytoskeletal fiber intracellular anatomical structure actin filament cellular anatomical entity actin cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005225	Small GTP-binding domain	Domain
A	IPR001806	Small GTPase	Family
A	IPR003578	Small GTPase Rho	Family
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR042201	Formin, FH2 domain superfamily	Homologous Superfamily
B	IPR010472	Formin, FH3 domain	Domain
B	IPR010473	Formin, GTPase-binding domain	Domain
B	IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain	Domain
B	IPR016024	Armadillo-type fold	Homologous Superfamily
B	IPR015425	Formin, FH2 domain	Domain
B	IPR011989	Armadillo-like helical	Homologous Superfamily
B	IPR051412	Formin Homology Diaphanous subfamily	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.