4E35

Crystal structure of CFTR Associated Ligand (CAL) PDZ domain bound to iCAL36-L (ANSRWPTSIL) peptide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4e35a_	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4e35b_	All beta proteins	PDZ domain-like	PDZ domain-like	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PDZ	e4e35A1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)
B	PDZ	e4e35B1	A: beta barrels	X: PDZ domain (From Topology)	H: PDZ domain (From Topology)	T: PDZ domain	F: PDZ	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)
B	2.30.42.10	Mainly Beta	Roll	Pdz3 Domain	PDZ domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00595	PDZ domain (PDZ)	PDZ domain	PDZ domains are found in diverse signaling proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Golgi-associated PDZ and coiled-coil motif-containing protein	protein binding binding transmembrane transporter binding molecular sequestering activity identical protein binding	protein localization regulation of localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization biological regulation negative regulation of biological process localization negative regulation of protein localization to cell surface protein localization to cell surface regulation of cellular localization cellular macromolecule localization macromolecule localization negative regulation of cellular process protein localization regulation of localization cellular localization regulation of biological process regulation of cellular process regulation of protein localization biological regulation negative regulation of biological process localization negative regulation of protein localization to cell surface protein localization to cell surface regulation of cellular localization cellular macromolecule localization macromolecule localization negative regulation of cellular process regulation of protein localization to cell surface cellular process negative regulation of protein localization apical protein localization Golgi to plasma membrane transport post-Golgi vesicle-mediated transport transport localization within membrane establishment of localization vesicle-mediated transport vesicle-mediated transport to the plasma membrane Golgi vesicle transport negative regulation of ion transmembrane transporter activity negative regulation of monoatomic anion transport negative regulation of monoatomic ion transport monoatomic ion transmembrane transport regulation of transmembrane transporter activity negative regulation of transport regulation of monoatomic ion transmembrane transport negative regulation of transmembrane transport regulation of transporter activity negative regulation of monoatomic ion transmembrane transport regulation of monoatomic anion transport monoatomic anion transmembrane transport monoatomic ion transport negative regulation of anion channel activity regulation of monoatomic ion transmembrane transporter activity regulation of transport regulation of monoatomic ion transport negative regulation of transporter activity negative regulation of molecular function regulation of monoatomic anion transmembrane transport regulation of anion channel activity transmembrane transport regulation of molecular function regulation of transmembrane transport monoatomic anion transport negative regulation of anion transmembrane transport establishment of protein localization nitrogen compound transport protein transport establishment of localization in cell intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport	membrane-bounded organelle intracellular anatomical structure transport vesicle intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle trans-Golgi network transport vesicle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle cytoplasm membrane-bounded organelle intracellular anatomical structure transport vesicle intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle trans-Golgi network transport vesicle cytoplasmic vesicle organelle clathrin-coated vesicle coated vesicle cytoplasm Golgi-associated vesicle vesicle vacuolar membrane membrane lytic vacuole vacuole lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane lysosome Golgi apparatus cytoplasmic vesicle membrane vesicle membrane Golgi-associated vesicle membrane Golgi membrane postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction asymmetric synapse cell periphery plasma membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection protein-containing complex
C, D	iCAL50 peptide	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036034	PDZ superfamily	Homologous Superfamily
A, B	IPR038879	Golgi-associated PDZ and coiled-coil motif-containing protein	Family
A, B	IPR001478	PDZ domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9HD26	melanoma atrial fibrillation Alzheimer disease cutaneous melanoma lung carcinoma non-small cell lung carcinoma Pick disease glioblastoma medulloblastoma osteosarcoma progressive supranuclear palsy atypical teratoid rhabdoid tumor large cell medulloblastoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.