Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
A [auth C]d4en3c2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) CD1, alpha-3 domain human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
A [auth C]d4en3c1 Alpha and beta proteins (a+b) MHC antigen-recognition domain MHC antigen-recognition domain MHC antigen-recognition domain CD1, alpha-1 and alpha-2 domains human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth A]d4en3a2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth A]d4en3a1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth A]d4en3a3 Artifacts Tags Tags Tags C-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
C [auth B]d4en3b2 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) beta2-microglobulin human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
C [auth B]d4en3b1 All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin automated matches automated matches human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Dd4en3d_ All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin C1 set domains (antibody constant domain-like) beta2-microglobulin human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth C]SCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8054665 3000071 SCOP2B (2022-06-29)
A [auth C]SCOP2B SuperfamilyMHC antigen-recognition domain 8035878 3000521 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyImmunoglobulin (Ig) domain-like 8003766 3000071 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth C]C1-set_2e4en3C4 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)
A [auth C]MHC_Ie4en3C3 A: a+b two layersX: MHC antigen-recognition domain (From Topology)H: MHC antigen-recognition domain (From Topology)T: MHC antigen-recognition domainF: MHC_IECOD (1.6)
B [auth A]DUF1968e4en3A3 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: DUF1968ECOD (1.6)
B [auth A]V-set_4e4en3A4 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_4ECOD (1.6)
C [auth B]C1-sete4en3B2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-setECOD (1.6)
C [auth B]V-set_3e4en3B1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_3ECOD (1.6)
DC1-set_2e4en3D1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: C1-set_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
A [auth C]CD1D I-ALPHA-LIKE Homo sapiens (human) CD1D*01 G-DOMAIN G-ALPHA1-LIKE, G-DOMAIN G-ALPHA2-LIKE, C-LIKE-DOMAIN C-LIKE RPI-MH1Like MH1LIKE-ALPHA-LIKE_B2M IMGT (202444-0)
B [auth A]TR NKT TRAV17*01-TRAJ18*01, TRBV25-1*01 TR-ALPHA Homo sapiens (human) TRAV17*01, TRAJ18*01, TRAC*01 V-DOMAIN V-ALPHA, C-DOMAIN C-ALPHA TR TR-ALPHA_BETA-2 IMGT (202444-0)
C [auth B]TR NKT TRAV17*01-TRAJ18*01, TRBV25-1*01 TR-BETA-2 Homo sapiens (human) TRBV25-1*01, TRBJ2-7*01, TRBC2*01, TRBC2*02 V-DOMAIN V-BETA, C-DOMAIN C-BETA-2 TR TR-ALPHA_BETA-2 IMGT (202444-0)
CD1D B2M Homo sapiens (human) B2M*01, B2M*02 C-LIKE-DOMAIN C-LIKE RPI-MH1Like MH1LIKE-ALPHA-LIKE_B2M IMGT (202444-0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth C]PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
B [auth A]PF09291Domain of unknown function (DUF1968) (DUF1968)Domain of unknown function (DUF1968)Members of this family are found in mammalian T-cell antigen receptor, and adopt an immunoglobulin-like beta-sandwich fold, with seven strands in two beta-sheets in a Greek-key topology. Their exact function has not, as yet, been determined.Domain
C [auth B]PF07686Immunoglobulin V-set domain (V-set)Immunoglobulin V-set domainThis domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.Domain
C [auth B]PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain
PF07654Immunoglobulin C1-set domain (C1-set)Immunoglobulin C1-set domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth C]Antigen-presenting glycoprotein CD1d
B [auth A]HUMAN NKT TCR ALPHA CHAIN- - -
C [auth B]HUMAN NKT TCR BETA CHAIN
Beta-2-microglobulin

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth C]IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
A [auth C]IPR050208Antigen-presenting and immune regulatory MHC class I-relatedFamily
A [auth C]IPR003597Immunoglobulin C1-setDomain
A [auth C]IPR011161MHC class I-like antigen recognition-likeDomain
A [auth C]IPR011162MHC classes I/II-like antigen recognition proteinHomologous Superfamily
A [auth C]IPR037055MHC class I-like antigen recognition-like superfamilyHomologous Superfamily
A [auth C]IPR013783Immunoglobulin-like foldHomologous Superfamily
A [auth C]IPR007110Immunoglobulin-like domainDomain
B [auth A]IPR052051T cell receptor complex componentFamily
B [auth A]IPR013783Immunoglobulin-like foldHomologous Superfamily
B [auth A]IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
B [auth A]IPR013106Immunoglobulin V-set domainDomain
B [auth A]IPR003599Immunoglobulin domain subtypeDomain
B [auth A]IPR007110Immunoglobulin-like domainDomain
B [auth A]IPR015370T-cell receptor alpha chain, constant domainDomain
C [auth B]IPR003597Immunoglobulin C1-setDomain
C [auth B]IPR013783Immunoglobulin-like foldHomologous Superfamily
C [auth B]IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
C [auth B]IPR013106Immunoglobulin V-set domainDomain
C [auth B]IPR003599Immunoglobulin domain subtypeDomain
C [auth B]IPR007110Immunoglobulin-like domainDomain
C [auth B]IPR050413T cell receptor beta variableFamily
IPR036179Immunoglobulin-like domain superfamilyHomologous Superfamily
IPR003006Immunoglobulin/major histocompatibility complex, conserved siteConserved Site
IPR013783Immunoglobulin-like foldHomologous Superfamily
IPR007110Immunoglobulin-like domainDomain
IPR050160Major Histocompatibility Complex/ImmunoglobulinFamily
IPR003597Immunoglobulin C1-setDomain
IPR015707Beta-2-MicroglobulinFamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A [auth C]PharosP15813
PharosP61769