4F9Z

Crystal Structure of human ERp27

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	Thioredoxin_6_N	e4f9zD2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Thioredoxin_6_N	ECOD (1.6)
A [auth D]	Thioredoxin_6_C	e4f9zD1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Thioredoxin_6_C	ECOD (1.6)
B [auth A]	Thioredoxin_6_N	e4f9zA2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Thioredoxin_6_N	ECOD (1.6)
B [auth A]	Thioredoxin_6_C	e4f9zA3	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Thioredoxin_6_C	ECOD (1.6)
C [auth B]	Thioredoxin_6_N	e4f9zB2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Thioredoxin_6_N	ECOD (1.6)
C [auth B]	Thioredoxin_6_C	e4f9zB1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Thioredoxin_6_C	ECOD (1.6)
D [auth C]	Thioredoxin_6_N	e4f9zC2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Thioredoxin_6_N	ECOD (1.6)
D [auth C]	Thioredoxin_6_C	e4f9zC1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Thioredoxin_6_C	ECOD (1.6)
E	Thioredoxin_6_N	e4f9zE2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Thioredoxin_6_N	ECOD (1.6)
E	Thioredoxin_6_C	e4f9zE3	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: Thioredoxin_6_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth D]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
B [auth A]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
C [auth B]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
D [auth C]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
E	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D], B [auth A], C [auth B], D [auth C], E	PF13848	Thioredoxin-like domain (Thioredoxin_6)	Thioredoxin-like domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], B [auth A], C [auth B], D [auth C], E	Endoplasmic reticulum resident protein 27	-	protein folding biosynthetic process metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation response to stimulus response to topologically incorrect protein response to stress response to unfolded protein protein folding biosynthetic process metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation response to stimulus response to topologically incorrect protein response to stress response to unfolded protein cellular response to stimulus cellular response to stress response to endoplasmic reticulum stress	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle cellular anatomical structure organelle lumen organelle endoplasmic reticulum cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D], B [auth A], C [auth B], D [auth C], E	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth D], B [auth A], C [auth B], D [auth C], E	Pharos: Q96DN0	atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant pancreatic neoplasm osteoarthritis pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma Crohn disease interstitial cystitis lung carcinoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm ductal breast carcinoma in situ invasive ductal breast carcinoma atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant pancreatic neoplasm osteoarthritis pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma Crohn disease interstitial cystitis lung carcinoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm ductal breast carcinoma in situ invasive ductal breast carcinoma malignant glioma non-small cell lung carcinoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.