4GUK

New crystal form structure of human NCS1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4guka1	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Frequenin (neuronal calcium sensor 1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4guka2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth C]	d4gukc1	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Frequenin (neuronal calcium sensor 1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth C]	d4gukc2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth B]	d4gukb1	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Frequenin (neuronal calcium sensor 1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth B]	d4gukb2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d4gukd1	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Frequenin (neuronal calcium sensor 1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d4gukd2	Artifacts	Tags	Tags	Tags	C-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EF-hand	8032675	3001983	SCOP2B (2022-06-29)
B [auth C]	SCOP2B Superfamily	EF-hand	8032675	3001983	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	EF-hand	8032675	3001983	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	EF-hand	8032675	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EF-hand_7_2	e4gukA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_2	ECOD (1.6)
A	EF-hand_7_10	e4gukA2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_10	ECOD (1.6)
B [auth C]	EF-hand_7_2	e4gukC4	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_2	ECOD (1.6)
B [auth C]	EF-hand_7_10	e4gukC3	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_10	ECOD (1.6)
C [auth B]	EF-hand_7_2	e4gukB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_2	ECOD (1.6)
C [auth B]	EF-hand_7_10	e4gukB2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_10	ECOD (1.6)
D	EF-hand_7_2	e4gukD1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_2	ECOD (1.6)
D	EF-hand_7_10	e4gukD2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_10	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B [auth C]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
C [auth B]	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
D	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C], C [auth B], D	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain
A, B [auth C], C [auth B], D	PF00036	EF hand (EF-hand_1)	EF hand	The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typica ...	The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth B], D	Neuronal calcium sensor 1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity cyclase regulator activity enzyme activator activity cyclase activator activity molecular function activator activity calcium sensitive guanylate cyclase activator activity guanylate cyclase activator activity molecular function regulator activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity cyclase regulator activity enzyme activator activity cyclase activator activity molecular function activator activity calcium sensitive guanylate cyclase activator activity guanylate cyclase activator activity molecular function regulator activity guanylate cyclase regulator activity calcium channel activity monoatomic cation transmembrane transporter activity voltage-gated calcium channel activity gated channel activity monoatomic ion channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity monoatomic cation channel activity passive transmembrane transporter activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity channel activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity	regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process cellular developmental process cell projection organization cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process cellular developmental process cell projection organization cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development generation of neurons neuron development cellular process regulation of plasma membrane bounded cell projection organization	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization synapse cell junction asymmetric synapse perinuclear region of cytoplasm cell periphery plasma membrane membrane axon cell projection neuron projection plasma membrane bounded cell projection somatodendritic compartment dendrite dendritic tree

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth B], D	IPR028846	Recoverin family	Family
A, B [auth C], C [auth B], D	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, B [auth C], C [auth B], D	IPR002048	EF-hand domain	Domain
A, B [auth C], C [auth B], D	IPR011992	EF-hand domain pair	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B [auth C], C [auth B], D	Pharos: P62166	primitive neuroectodermal tumor Alzheimer disease Barrett esophagus cocaine dependence large cell medulloblastoma malignant ependymoma oligodendroglioma Pick disease schizophrenia astrocytic tumor bipolar disorder congestive heart failure lung adenocarcinoma malignant glioma osteosarcoma primitive neuroectodermal tumor Alzheimer disease Barrett esophagus cocaine dependence large cell medulloblastoma malignant ependymoma oligodendroglioma Pick disease schizophrenia astrocytic tumor bipolar disorder congestive heart failure lung adenocarcinoma malignant glioma osteosarcoma pilocytic astrocytoma tuberculosis atypical teratoid rhabdoid tumor breast cancer glioblastoma lung cancer medulloblastoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.