4HWW

Crystal structure of human Arginase-1 complexed with inhibitor 9

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4hwwa_	Alpha and beta proteins (a/b)	Arginase/deacetylase	Arginase/deacetylase	Arginase-like amidino hydrolases	Arginase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4hwwb_	Alpha and beta proteins (a/b)	Arginase/deacetylase	Arginase/deacetylase	Arginase-like amidino hydrolases	Arginase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Arginase/deacetylase-like	8036933	3000260	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Arginase/deacetylase-like	8036933	3000260	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Arginase	e4hwwA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Arginase/deacetylase	F: Arginase	ECOD (1.6)
B	Arginase	e4hwwB1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Arginase/deacetylase	F: Arginase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.800.10	Alpha Beta	3-Layer(aba) Sandwich	Arginase	Chain A	CATH (4.3.0)
B	3.40.800.10	Alpha Beta	3-Layer(aba) Sandwich	Arginase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00491	Arginase family (Arginase)	Arginase family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Arginase-1	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds arginase activity cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to protozoan response to external stimulus response to biotic stimulus response to protozoan defense response to other organism response to stress response to external biotic stimulus cellular response to stimulus regulation of cellular process response to type II interferon biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to protozoan response to external stimulus response to biotic stimulus response to protozoan defense response to other organism response to stress response to external biotic stimulus cellular response to stimulus regulation of cellular process response to type II interferon negative regulation of biological process response to cytokine regulation of signal transduction regulation of type II interferon-mediated signaling pathway cellular response to type II interferon cell communication negative regulation of response to type II interferon interferon-mediated signaling pathway cellular response to cytokine stimulus regulation of immune system process signal transduction regulation of biological process immune response regulation of innate immune response negative regulation of immune response type II interferon-mediated signaling pathway regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus regulation of response to stimulus response to chemical negative regulation of response to external stimulus negative regulation of defense response regulation of immune response regulation of response to type II interferon regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus negative regulation of response to biotic stimulus negative regulation of signaling signaling negative regulation of cell communication cytokine-mediated signaling pathway regulation of response to stress negative regulation of cellular process innate immune response negative regulation of type II interferon-mediated signaling pathway regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cytokine-mediated signaling pathway biological regulation defense response to symbiont negative regulation of signal transduction response to peptide negative regulation of immune system process negative regulation of cytokine-mediated signaling pathway immune system process regulation of cell communication cellular process negative regulation of innate immune response negative regulation of lymphocyte proliferation multicellular organismal process regulation of leukocyte activation regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation T cell activation lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion regulation of cell population proliferation mononuclear cell proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of activated T cell proliferation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation activated T cell proliferation negative regulation of mononuclear cell proliferation cell adhesion cell-cell adhesion regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of activated T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation adaptive immune response adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte mediated immunity regulation of immune effector process T cell mediated immunity T-helper 2 cell cytokine production negative regulation of lymphocyte mediated immunity T cell cytokine production negative regulation of cellular metabolic process type 2 immune response regulation of T-helper 2 cell cytokine production cytokine production regulation of type 2 immune response leukocyte mediated immunity negative regulation of T-helper 2 cell cytokine production regulation of T cell mediated immunity negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response regulation of adaptive immune response cellular metabolic process negative regulation of metabolic process negative regulation of immune effector process regulation of cellular metabolic process negative regulation of adaptive immune response negative regulation of cellular biosynthetic process immune effector process negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of gene expression negative regulation of type 2 immune response regulation of leukocyte mediated immunity negative regulation of production of molecular mediator of immune response negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response negative regulation of T cell mediated immunity regulation of metabolic process cellular biosynthetic process negative regulation of T cell cytokine production regulation of T cell cytokine production CD4-positive, alpha-beta T cell cytokine production regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of cytokine production cytokine production involved in immune response negative regulation of macromolecule metabolic process production of molecular mediator of immune response regulation of biosynthetic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of lymphocyte mediated immunity negative regulation of biosynthetic process negative regulation of leukocyte mediated immunity neutrophil-mediated killing of symbiont cell regulation of myeloid leukocyte mediated immunity positive regulation of response to biotic stimulus positive regulation of leukocyte mediated immunity neutrophil-mediated killing of fungus regulation of neutrophil mediated killing of fungus disruption of cell in another organism regulation of killing of cells of another organism regulation of programmed cell death myeloid leukocyte mediated immunity positive regulation of neutrophil mediated cytotoxicity positive regulation of leukocyte mediated cytotoxicity positive regulation of neutrophil mediated killing of symbiont cell biological process involved in interaction with symbiont positive regulation of immune system process killing of cells of another organism positive regulation of programmed cell death leukocyte mediated cytotoxicity cell death regulation of defense response to fungus positive regulation of myeloid leukocyte mediated immunity positive regulation of defense response regulation of cell killing positive regulation of cell killing disruption of anatomical structure in another organism positive regulation of killing of cells of another organism positive regulation of biological process biological process involved in symbiotic interaction positive regulation of response to stimulus neutrophil mediated immunity positive regulation of response to external stimulus positive regulation of neutrophil mediated killing of fungus positive regulation of immune effector process modulation of process of another organism positive regulation of cellular process regulation of biological process involved in symbiotic interaction neutrophil mediated cytotoxicity regulation of neutrophil mediated cytotoxicity regulation of leukocyte mediated cytotoxicity defense response to fungus killing by host of symbiont cells regulation of neutrophil mediated killing of symbiont cell response to fungus programmed cell death cell killing ornithine metabolic process arginine catabolic process to ornithine catabolic process oxoacid metabolic process glutamine family amino acid catabolic process amino acid metabolic process arginine catabolic process organic acid metabolic process organic acid catabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process cellular catabolic process arginine metabolic process non-proteinogenic amino acid metabolic process carboxylic acid catabolic process small molecule metabolic process amino acid catabolic process carboxylic acid metabolic process L-amino acid catabolic process primary metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process alpha-amino acid catabolic process proteinogenic amino acid catabolic process small molecule catabolic process nitrogen cycle metabolic process urea cycle amide biosynthetic process amide metabolic process urea metabolic process	extracellular region cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen extracellular region cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle specific granule lumen secretory granule secretory vesicle vesicle specific granule lytic vacuole vacuolar lumen lysosome azurophil granule vacuole azurophil granule lumen primary lysosome extracellular space nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR014033	Arginase	Family
A, B	IPR020855	Ureohydrolase, manganese-binding site	Binding Site
A, B	IPR023696	Ureohydrolase domain superfamily	Homologous Superfamily
A, B	IPR006035	Ureohydrolase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P05089	hyperargininemia leishmaniasis silicosis myopathy asbestosis lung adenocarcinoma asthma disease of pilosebaceous unit inborn errors of metabolism muscle tissue disease osteosarcoma Adenocarcinoma of Lung cancer cholestasis immune system disease hyperargininemia leishmaniasis silicosis myopathy asbestosis lung adenocarcinoma asthma disease of pilosebaceous unit inborn errors of metabolism muscle tissue disease osteosarcoma Adenocarcinoma of Lung cancer cholestasis immune system disease inherited amino acid metabolic disorder muscular disease periodontitis primitive neuroectodermal tumor drug-induced liver injury intellectual disability MALT lymphoma precancerous condition psoriasis atopic eczema urea cycle disorder

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.