4I64

3-hydroxy-3-methylglutaryl Coenzyme A reductase from Pseudomonas mevalonii, a high resolution native structure

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4i64b2	Alpha and beta proteins (a+b)	Ferredoxin-like	NAD-binding domain of HMG-CoA reductase	NAD-binding domain of HMG-CoA reductase	NAD-binding domain of HMG-CoA reductase	(Pseudomonas sp. 'mevalonii ) [TaxId: 32044 ],	SCOPe (2.08)
B	d4i64b1	Alpha and beta proteins (a+b)	Substrate-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	(Pseudomonas sp. 'mevalonii ) [TaxId: 32044 ],	SCOPe (2.08)
A	d4i64a2	Alpha and beta proteins (a+b)	Ferredoxin-like	NAD-binding domain of HMG-CoA reductase	NAD-binding domain of HMG-CoA reductase	NAD-binding domain of HMG-CoA reductase	(Pseudomonas sp. 'mevalonii ) [TaxId: 32044 ],	SCOPe (2.08)
A	d4i64a1	Alpha and beta proteins (a+b)	Substrate-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	Substrate-binding domain of HMG-CoA reductase	(Pseudomonas sp. 'mevalonii ) [TaxId: 32044 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Substrate-binding domain of HMG-CoA reductase	8040285	3001471	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	NAD-binding domain of HMG-CoA reductase	8040282	3001200	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Substrate-binding domain of HMG-CoA reductase	8040285	3001471	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Substrate-binding domain of HMG-CoA reductase	8040285	3001471	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Substrate-binding domain of HMG-CoA reductase	8040285	3001471	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	NAD-binding domain of HMG-CoA reductase	8040282	3001200	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	HMG-CoA_red_2nd	e4i64B1	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: NAD-binding domain of HMG-CoA reductase	F: HMG-CoA_red_2nd	ECOD (1.6)
B	HMG-CoA_red_1st	e4i64B2	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: Substrate-binding domain of HMG-CoA reductase	F: HMG-CoA_red_1st	ECOD (1.6)
A	HMG-CoA_red_2nd	e4i64A1	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: NAD-binding domain of HMG-CoA reductase	F: HMG-CoA_red_2nd	ECOD (1.6)
A	HMG-CoA_red_1st	e4i64A2	A: a+b two layers	X: Alpha-beta plaits	H: HMG-CoA reductase	T: Substrate-binding domain of HMG-CoA reductase	F: HMG-CoA_red_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.90.770.10	Alpha Beta	Alpha-Beta Complex	3-hydroxy-3-methylglutaryl-coenzyme A Reductase	Chain A, domain 2	CATH (4.3.0)
B	3.30.70.420	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain	CATH (4.3.0)
A	3.90.770.10	Alpha Beta	Alpha-Beta Complex	3-hydroxy-3-methylglutaryl-coenzyme A Reductase	Chain A, domain 2	CATH (4.3.0)
A	3.30.70.420	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00368	Hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA_red)	Hydroxymethylglutaryl-coenzyme A reductase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	3-hydroxy-3-methylglutaryl-coenzyme A reductase	oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors hydroxymethylglutaryl-CoA reductase (NADPH) activity catalytic activity hydroxymethylglutaryl-CoA reductase (NADH) activity	nucleoside phosphate metabolic process cellular metabolic process primary metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process sulfur compound metabolic process cellular process small molecule metabolic process amide metabolic process phosphorus metabolic process nucleoside phosphate metabolic process cellular metabolic process primary metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process sulfur compound metabolic process cellular process small molecule metabolic process amide metabolic process phosphorus metabolic process coenzyme A metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR009029	Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily	Homologous Superfamily
A, B	IPR023074	Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily	Homologous Superfamily
A, B	IPR009023	Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily	Homologous Superfamily
A, B	IPR002202	Hydroxymethylglutaryl-CoA reductase, class I/II	Family
A, B	IPR004553	Hydroxymethylglutaryl-CoA reductase, bacterial-type	Family
A, B	IPR023076	Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.