4IZ6
Structure of EntE and EntB, an NRPS adenylation-PCP fusion protein with pseudo translational symmetry
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | AMP-binding_3rd | e4iz6A5 | A: beta barrels | X: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology) | H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology) | T: beta-barrel domain in acetyl-CoA synthetase-like proteins | F: AMP-binding_3rd | ECOD (1.6) |
A | PP-binding | e4iz6A4 | A: alpha bundles | X: ACP-like | H: Acyl-carrier protein (ACP) (From Topology) | T: Acyl-carrier protein (ACP) | F: PP-binding | ECOD (1.6) |
A | AMP-binding_C | e4iz6A10 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: a+b domain in acetyl-CoA synthetase-like proteins (From Topology) | T: a+b domain in acetyl-CoA synthetase-like proteins | F: AMP-binding_C | ECOD (1.6) |
A | AMP-binding_1st | e4iz6A11 | A: a/b three-layered sandwiches | X: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | T: Rossmann-like domain in Acetyl-CoA synthetase-like proteins | F: AMP-binding_1st | ECOD (1.6) |
A | AMP-binding_2nd | e4iz6A9 | A: a/b three-layered sandwiches | X: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | T: Rossmann-like domain in Acetyl-CoA synthetase-like proteins | F: AMP-binding_2nd | ECOD (1.6) |
B | AMP-binding_3rd | e4iz6B5 | A: beta barrels | X: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology) | H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology) | T: beta-barrel domain in acetyl-CoA synthetase-like proteins | F: AMP-binding_3rd | ECOD (1.6) |
B | PP-binding | e4iz6B9 | A: alpha bundles | X: ACP-like | H: Acyl-carrier protein (ACP) (From Topology) | T: Acyl-carrier protein (ACP) | F: PP-binding | ECOD (1.6) |
B | AMP-binding_C | e4iz6B7 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: a+b domain in acetyl-CoA synthetase-like proteins (From Topology) | T: a+b domain in acetyl-CoA synthetase-like proteins | F: AMP-binding_C | ECOD (1.6) |
B | AMP-binding_1st | e4iz6B8 | A: a/b three-layered sandwiches | X: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | T: Rossmann-like domain in Acetyl-CoA synthetase-like proteins | F: AMP-binding_1st | ECOD (1.6) |
B | AMP-binding_2nd | e4iz6B6 | A: a/b three-layered sandwiches | X: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | T: Rossmann-like domain in Acetyl-CoA synthetase-like proteins | F: AMP-binding_2nd | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.50.12780 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | ANL, N-terminal domain | CATH (4.3.0) |
A | 3.30.300.30 | Alpha Beta | 2-Layer Sandwich | GMP Synthetase | Chain A, domain 3 | CATH (4.3.0) |
A | 1.10.1200.10 | Mainly Alpha | Orthogonal Bundle | Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein | Chain A | CATH (4.3.0) |
B | 3.40.50.12780 | Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | ANL, N-terminal domain | CATH (4.3.0) |
B | 3.30.300.30 | Alpha Beta | 2-Layer Sandwich | GMP Synthetase | Chain A, domain 3 | CATH (4.3.0) |
B | 1.10.1200.10 | Mainly Alpha | Orthogonal Bundle | Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein | Chain A | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00501 | AMP-binding enzyme (AMP-binding) | AMP-binding enzyme | - | Family | |
PF13193 | AMP-binding enzyme C-terminal domain (AMP-binding_C) | AMP-binding enzyme C-terminal domain | This is a small domain that is found C terminal to Pfam:PF00501. It has a central beta sheet core that is flanked by alpha helices. | Domain | |
PF00550 | Phosphopantetheine attachment site (PP-binding) | Phosphopantetheine attachment site | A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes memb ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR009081 | Phosphopantetheine binding ACP domain | Domain | |
IPR000868 | Isochorismatase-like | Domain | |
IPR050272 | Isochorismatase-like hydrolase | Family | |
IPR036380 | Isochorismatase-like superfamily | Homologous Superfamily | |
IPR036736 | ACP-like superfamily | Homologous Superfamily | |
IPR016291 | Isochorismatase | Family | |
IPR011963 | 2,3-dihydroxybenzoate-AMP ligase | Family | |
IPR050237 | ATP-dependent AMP-binding enzyme | Family | |
IPR020845 | AMP-binding, conserved site | Conserved Site | |
IPR045851 | AMP-binding enzyme, C-terminal domain superfamily | Homologous Superfamily | |
IPR042099 | ANL, N-terminal domain | Homologous Superfamily | |
IPR025110 | AMP-binding enzyme, C-terminal domain | Domain | |
IPR000873 | AMP-dependent synthetase/ligase domain | Domain |