Annotations: 4K6L

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
F	d4k6lf_	Alpha and beta proteins (a+b)	DNase I-like	DNase I-like	automated matches	automated matches	(Salmonella enterica subsp. enterica serovar Typhi ) [TaxId: 90370 ],	SCOPe (2.08)
G	d4k6lg_	Alpha and beta proteins (a+b)	ADP-ribosylation	ADP-ribosylation	automated matches	automated matches	(Salmonella enterica subsp. enterica serovar Typhi ) [TaxId: 90370 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F	SCOP2 Family	DNase I-like	8061768	4002213	SCOP2 (2022-06-29)
F	SCOP2 Superfamily	DNase I-like	8061769	3000957	SCOP2 (2022-06-29)
G	SCOP2B Superfamily	ADP-ribosylation	8102605	3001208	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pertussis_S2S3	e4k6lA1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
B	Pertussis_S2S3	e4k6lB1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
C	Pertussis_S2S3	e4k6lC1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
D	Pertussis_S2S3	e4k6lD1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
E	Pertussis_S2S3	e4k6lE1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Pertussis_S2S3	ECOD (1.6)
F	Exo_endo_phos	e4k6lF1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)
G	Pertussis_S1	e4k6lG1	A: a+b complex topology	X: ADP-ribosylation (From Topology)	H: ADP-ribosylation (From Topology)	T: ADP-ribosylation	F: Pertussis_S1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
B	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
C	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
D	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
E	2.40.50.110	Mainly Beta	Beta Barrel	OB fold (Dihydrolipoamide Acetyltransferase, E2P)		CATH (4.3.0)
F	3.60.10.10	Alpha Beta	4-Layer Sandwich	Deoxyribonuclease I	Chain A	CATH (4.3.0)
G	3.90.210.10	Alpha Beta	Alpha-Beta Complex	Heat-Labile Enterotoxin	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E	PF02918	Pertussis toxin, subunit 2 and 3, C-terminal domain (Pertussis_S2S3)	Pertussis toxin, subunit 2 and 3, C-terminal domain	-	Domain
F	PF03372	Endonuclease/Exonuclease/phosphatase family (Exo_endo_phos)	Endonuclease/Exonuclease/phosphatase family	This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3. ...	This large family of proteins includes magnesium dependent endonucleases and a large number of phosphatases involved in intracellular signalling [1]. This family includes: AP endonuclease proteins EC:4.2.99.18 e.g Swiss:P27695, DNase I proteins EC:3.1.21.1 e.g. Swiss:P24855, Synaptojanin an inositol-1,4,5-trisphosphate phosphatase EC:3.1.3.56 Swiss:O43426, Sphingomyelinase EC:3.1.4.12 Swiss:P11889 and Nocturnin Swiss:O35710.	Domain
G	PF02917	Pertussis toxin, subunit 1 (Pertussis_S1)	Pertussis toxin, subunit 1	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E	Putative pertussis-like toxin subunit	-	-	extracellular region cellular anatomical entity
F	Cytolethal distending toxin subunit B homolog	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity toxin activity	-	extracellular region cellular anatomical entity
G	Putative pertussis-like toxin subunit	pentosyltransferase activity catalytic activity, acting on a protein glycosyltransferase activity NAD+-protein ADP-ribosyltransferase activity transferase activity catalytic activity NAD+-protein poly-ADP-ribosyltransferase activity	-	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E	IPR008992	Enterotoxin	Homologous Superfamily
A, B, C, D, E	IPR020063	Bordetella pertussis toxin B, subunit 2/3, C-terminal	Domain
F	IPR005135	Endonuclease/exonuclease/phosphatase	Domain
F	IPR003539	Cytolethal distending toxin B	Family
F	IPR036691	Endonuclease/exonuclease/phosphatase superfamily	Homologous Superfamily
G	IPR003898	Bordetella pertussis toxin A	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.