Annotations: 4LOL

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4lola_	Alpha and beta proteins (a+b)	STING C-terminal-like	STING, TM173 CTD-like	Tyrosinase cofactor MelC1	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d4lolb1	Alpha and beta proteins (a+b)	STING C-terminal-like	STING, TM173 CTD-like	Tyrosinase cofactor MelC1	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d4lolb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	STING C-terminal domain-like	8052390	3002114	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	STING C-terminal domain-like	8052390	3002114	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TMEM173	e4lolA1	A: a/b three-layered sandwiches	X: STING C-terminal domain (From Topology)	H: STING C-terminal domain (From Topology)	T: STING C-terminal domain	F: TMEM173	ECOD (1.6)
B	TMEM173	e4lolB1	A: a/b three-layered sandwiches	X: STING C-terminal domain (From Topology)	H: STING C-terminal domain (From Topology)	T: STING C-terminal domain	F: TMEM173	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.5200	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
A	3.40.50.12100	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Stimulator of interferon genes protein	CATH (4.3.0)
B	1.20.5.5200	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	3.40.50.12100	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Stimulator of interferon genes protein	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF15009	Transmembrane protein 173 (TMEM173)	Transmembrane protein 173	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Stimulator of interferon genes protein	guanyl nucleotide binding binding cyclic nucleotide binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding cyclic-di-GMP binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding guanyl nucleotide binding binding cyclic nucleotide binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding cyclic-di-GMP binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding DNA-binding transcription factor binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity monoatomic ion channel activity proton channel activity monoatomic cation channel activity passive transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity cyclic GMP-AMP binding adenyl ribonucleotide binding adenyl nucleotide binding 2',3'-cyclic GMP-AMP binding identical protein binding protein homodimerization activity protein dimerization activity kinase binding enzyme binding protein kinase binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus positive regulation of biological process response to biotic stimulus positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus positive regulation of immune system process regulation of biological process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy autophagy autophagosome organization organelle organization metabolic process process utilizing autophagic mechanism regulation of biosynthetic process regulation of cellular process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process cellular response to nitrogen compound cellular response to stimulus cellular response to dsRNA cellular response to exogenous dsRNA cellular response to organic cyclic compound response to dsRNA response to nitrogen compound response to exogenous dsRNA cellular response to chemical stimulus response to chemical response to organic cyclic compound positive regulation of cell communication positive regulation of signal transduction regulation of type I interferon-mediated signaling pathway response to cytokine regulation of signal transduction cell communication interferon-mediated signaling pathway cellular response to type I interferon cellular response to cytokine stimulus signal transduction regulation of response to cytokine stimulus response to type I interferon signaling positive regulation of type I interferon-mediated signaling pathway positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway positive regulation of cellular process regulation of signaling cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway response to peptide type I interferon-mediated signaling pathway regulation of cell communication positive regulation of cytokine-mediated signaling pathway positive regulation of signaling cellular response to interferon-beta response to interferon-beta multicellular organismal process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process regulation of interferon-beta production interferon-beta production positive regulation of type I interferon production type I interferon production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of interferon-beta production positive regulation of cytokine production regulation of type I interferon production pattern recognition receptor signaling pathway cGAS/STING signaling pathway intracellular signal transduction immune response-activating signaling pathway innate immune response-activating signaling pathway cytoplasmic pattern recognition receptor signaling pathway intracellular receptor signaling pathway immune response-regulating signaling pathway defense response to virus antiviral innate immune response response to virus regulation of inflammatory response inflammatory response positive regulation of autophagy regulation of catabolic process regulation of autophagy positive regulation of catabolic process regulation of macroautophagy positive regulation of macroautophagy protein localization localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to endoplasmic reticulum regulation of defense response to virus positive regulation of defense response to virus by host regulation of defense response to virus by host positive regulation of DNA-templated transcription RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription reticulophagy	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen organelle subcompartment endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane vacuole autophagosome vacuolar membrane autophagosome membrane bounding membrane of organelle lytic vacuole lytic vacuole membrane lysosomal membrane lysosome Golgi apparatus protein-containing complex intracellular vesicle membrane protein complex cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle STING complex vesicle endosome Golgi membrane endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment peroxisome microbody perinuclear region of cytoplasm mitochondrial membrane mitochondrion organelle outer membrane organelle envelope mitochondrial envelope mitochondrial outer membrane outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR029158	Stimulator of interferon genes protein	Family
A, B	IPR047191	Stimulator of interferon genes protein, C-terminal	Domain
A, B	IPR038623	Stimulator of interferon genes protein, C-terminal domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.