4M1U
The crystal structure of Stx2 and a disaccharide ligand
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2 Family | Shiga toxin, A-chain | 8099971 | 4002413 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | Ribosome inactivating proteins (RIP) | 8099972 | 3001164 | SCOP2 (2022-06-29) |
B | SCOP2B Superfamily | Bacterial enterotoxins | 8099974 | 3000434 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Bacterial enterotoxins | 8099974 | 3000434 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Bacterial enterotoxins | 8099974 | 3000434 | SCOP2B (2022-06-29) |
E | SCOP2 Family | Bacterial AB5 toxins, B-subunits | 8099973 | 4001827 | SCOP2 (2022-06-29) |
E | SCOP2 Superfamily | Bacterial enterotoxins | 8099974 | 3000434 | SCOP2 (2022-06-29) |
F | SCOP2B Superfamily | Bacterial enterotoxins | 8099974 | 3000434 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | RIP | e4m1uA1 | A: a+b two layers | X: RIP/Polo-box domain | H: Ribosome inactivating proteins (RIP) (From Topology) | T: Ribosome inactivating proteins (RIP) | F: RIP | ECOD (1.6) |
B | SLT_beta | e4m1uB1 | A: beta barrels | X: OB-fold | H: Bacterial enterotoxins (From Topology) | T: Bacterial enterotoxins | F: SLT_beta | ECOD (1.6) |
C | SLT_beta | e4m1uC1 | A: beta barrels | X: OB-fold | H: Bacterial enterotoxins (From Topology) | T: Bacterial enterotoxins | F: SLT_beta | ECOD (1.6) |
D | SLT_beta | e4m1uD1 | A: beta barrels | X: OB-fold | H: Bacterial enterotoxins (From Topology) | T: Bacterial enterotoxins | F: SLT_beta | ECOD (1.6) |
E | SLT_beta | e4m1uE1 | A: beta barrels | X: OB-fold | H: Bacterial enterotoxins (From Topology) | T: Bacterial enterotoxins | F: SLT_beta | ECOD (1.6) |
F | SLT_beta | e4m1uF1 | A: beta barrels | X: OB-fold | H: Bacterial enterotoxins (From Topology) | T: Bacterial enterotoxins | F: SLT_beta | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.420.10 | Alpha Beta | 3-Layer(aba) Sandwich | Ricin (A subunit) | domain 1 | CATH (4.3.0) |
A | 4.10.470.10 | Few Secondary Structures | Irregular | Ricin (A Subunit), domain 2 | Ricin (A Subunit), domain 2 | CATH (4.3.0) |
B | 2.40.50.70 | Mainly Beta | Beta Barrel | OB fold (Dihydrolipoamide Acetyltransferase, E2P) | CATH (4.3.0) | |
C | 2.40.50.70 | Mainly Beta | Beta Barrel | OB fold (Dihydrolipoamide Acetyltransferase, E2P) | CATH (4.3.0) | |
D | 2.40.50.70 | Mainly Beta | Beta Barrel | OB fold (Dihydrolipoamide Acetyltransferase, E2P) | CATH (4.3.0) | |
E | 2.40.50.70 | Mainly Beta | Beta Barrel | OB fold (Dihydrolipoamide Acetyltransferase, E2P) | CATH (4.3.0) | |
F | 2.40.50.70 | Mainly Beta | Beta Barrel | OB fold (Dihydrolipoamide Acetyltransferase, E2P) | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00161 | Ribosome inactivating protein (RIP) | Ribosome inactivating protein | - | Domain | |
PF02258 | Shiga-like toxin beta subunit (SLT_beta) | Shiga-like toxin beta subunit | This family represents the B subunit of shiga-like toxin (SLT or verotoxin) produced by some strains of E.coli associated with hemorrhagic colitis and hemolytic uremic syndrome. SLT's are composed of one enzymatic A subunit and five cell binding B s ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR036041 | Ribosome-inactivating protein superfamily | Homologous Superfamily | |
IPR016331 | Shiga-like toxin, subunit A | Family | |
IPR017988 | Ribosome-inactivating protein conserved site | Conserved Site | |
IPR016139 | Ribosome-inactivating protein, subdomain 2 | Homologous Superfamily | |
IPR016138 | Ribosome-inactivating protein, subdomain 1 | Homologous Superfamily | |
IPR001574 | Ribosome-inactivating protein | Family | |
IPR008992 | Enterotoxin | Homologous Superfamily | |
IPR003189 | Shiga-like toxin, beta subunit | Family |