Crystal structure of anti-IL-23 antibody CNTO1959 at pH 9.5
External Resource: Annotation
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
A [auth L] | C1-set | e4m6mL1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set | ECOD (1.6) |
A [auth L] | V-set_3 | e4m6mL2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_3 | ECOD (1.6) |
B [auth H] | V-set_8 | e4m6mH1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: V-set_8 | ECOD (1.6) |
B [auth H] | C1-set_1 | e4m6mH2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: C1-set_1 | ECOD (1.6) |
Chain | Protein Name | Description | Organism Name | Gene Allele Name(s) | Domain Name(s) | Receptor Type | Receptor Description | Provenance Source |
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A [auth L] | CNTO1959 Fab | L-LAMBDA | Homo sapiens (human) | IGLV1-40*01, IGLJ2*01, IGLJ3*02, IGLJ3*01, IGLC2*01, IGLC2*02, IGLC3*04 | V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA | IG | FAB-GAMMA-1_LAMBDA | IMGT (202443-0) |
B [auth H] | CNTO1959 Fab | VH-CH1 | Homo sapiens (human) | IGHV5-51*01, IGHV5-51*03, IGHJ3*01, IGHJ4*01, IGHJ5*01, IGHJ5*02, IGHJ4*02, IGHJ4*03, IGHG1*01, IGHG1*02, IGHG1*04, IGHG1*05 | V-DOMAIN VH, C-DOMAIN CH1 | IG | FAB-GAMMA-1_LAMBDA | IMGT (202443-0) |
Chain | Chain Class | Chain Subclass | Chain Type | Antigen Name(s) | Provenance Source |
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A [auth L] | Light Chain | IGLV1 | Lambda | - | SAbDab (2024-11-01) |
B [auth H] | Heavy Chain | IGHV5 | - | - | SAbDab (2024-11-01) |