This is the C-terminal domain found in N-acyltransferase (NAT) proteins present in Actinoplanes teichomyceticus. In this organism, NAT proteins are responsible for N-acylation in the synthesis of the antibiotic teicoplanin. The C-terminal domain unde ...
This is the C-terminal domain found in N-acyltransferase (NAT) proteins present in Actinoplanes teichomyceticus. In this organism, NAT proteins are responsible for N-acylation in the synthesis of the antibiotic teicoplanin. The C-terminal domain undergoes a substantial conformational change upon binding to Acyl-CoA. The C-terminal domain is considered Gcn5-related N-acetyltransferase like (GNAT-like) but differs from the canonical GNAT fold in that it lacks the first beta strand and has an additional four alpha helices [1].
This is the N-terminal all helix domain found in N-acyltransferases (NATs), the gene products orf11 and dbv8. The all-helix domain is composed of eight helices with two helix-turn-helix motifs in tandem. It is structurally akin to the AAA+ protein fa ...
This is the N-terminal all helix domain found in N-acyltransferases (NATs), the gene products orf11 and dbv8. The all-helix domain is composed of eight helices with two helix-turn-helix motifs in tandem. It is structurally akin to the AAA+ protein family (ATPases associated with diverse cellular activities) [1].
