4NU1

Crystal structure of a transition state mimic of the GSK-3/Axin complex bound to phosphorylated N-terminal auto-inhibitory pS9 peptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8079613	3000066	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e4nu1A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Axin-1	SMAD binding protein binding binding R-SMAD binding ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity I-SMAD binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding identical protein binding p53 binding SMAD binding protein binding binding R-SMAD binding ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity I-SMAD binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding identical protein binding p53 binding signaling adaptor activity armadillo repeat domain binding protein domain specific binding protein homodimerization activity protein dimerization activity kinase binding protein kinase binding beta-catenin binding	developmental process multicellular organism development multicellular organismal process dorsal/ventral pattern formation dorsal/ventral axis specification anatomical structure development pattern specification process axis specification regionalization cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus developmental process multicellular organism development multicellular organismal process dorsal/ventral pattern formation dorsal/ventral axis specification anatomical structure development pattern specification process axis specification regionalization cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway biological regulation cell communication cellular process signal transduction Wnt signaling pathway localization cellular localization nucleocytoplasmic transport transport nuclear transport establishment of localization in cell intracellular transport establishment of localization apoptotic process cell death programmed cell death negative regulation of signaling regulation of canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process regulation of signaling regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication transcription elongation by RNA polymerase II RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of DNA-templated transcription elongation negative regulation of DNA-templated transcription regulation of transcription elongation by RNA polymerase II negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of DNA-templated transcription, elongation regulation of gene expression DNA-templated transcription elongation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular developmental process cell differentiation cell development positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process positive regulation of cellular process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation positive regulation of proteasomal protein catabolic process catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis proteasomal protein catabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process regulation of catalytic activity regulation of transferase activity positive regulation of molecular function positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development anatomical structure morphogenesis post-anal tail morphogenesis negative regulation of protein metabolic process positive regulation of cell communication positive regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade positive regulation of signaling protein polyubiquitination protein ubiquitination post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal epigenetic programming of gene expression epigenetic programming in the zygotic pronuclei epigenetic regulation of gene expression cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus fat cell differentiation regulation of developmental process negative regulation of developmental process regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of cell differentiation regulation of fat cell differentiation cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway formation of primary germ layer mesoderm morphogenesis embryonic morphogenesis tissue development gastrulation axial mesoderm development tissue morphogenesis axial mesoderm formation anatomical structure formation involved in morphogenesis axial mesoderm morphogenesis mesoderm formation mesoderm development head development regulation of peptidyl-threonine phosphorylation peptidyl-threonine modification positive regulation of peptidyl-threonine phosphorylation peptidyl-threonine phosphorylation regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of post-translational protein modification organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization supramolecular fiber organization cytoskeleton organization negative regulation of gene expression	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle membraneless organelle nuclear lumen cell periphery cell cortex plasma membrane membrane protein-containing complex catalytic complex beta-catenin destruction complex intracellular protein-containing complex cytoskeleton microtubule cytoskeleton Wnt signalosome cytoplasmic vesicle intracellular vesicle vesicle lateral plasma membrane
A	Glycogen synthase kinase-3 beta	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein binding kinase binding enzyme binding protein kinase binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups beta-catenin binding tau-protein kinase activity cytoskeletal protein binding tau protein binding p53 binding ionotropic glutamate receptor binding signaling receptor binding glutamate receptor binding protein serine kinase activity cell adhesion molecule binding protein-containing complex binding integrin binding protein serine/threonine kinase binding dynein complex binding	cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication positive regulation of response to stimulus synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality positive regulation of cellular process trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication cellular process excitatory postsynaptic potential regulation of membrane potential positive regulation of signaling long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of long-term synaptic potentiation protein localization cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein export from nucleus establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization nuclear export intracellular protein transport canonical Wnt signaling pathway Wnt signaling pathway cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation regulation of dopaminergic neuron differentiation anatomical structure development negative regulation of cellular process negative regulation of dopaminergic neuron differentiation negative regulation of cell differentiation system development developmental process dopaminergic neuron differentiation negative regulation of developmental process nervous system development generation of neurons negative regulation of neuron differentiation regulation of neuron differentiation extrinsic apoptotic signaling pathway via death domain receptors negative regulation of signaling regulation of programmed cell death extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process negative regulation of extrinsic apoptotic signaling pathway via death domain receptors cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway via death domain receptors apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis axon extension positive regulation of nervous system development axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process cell projection morphogenesis neuron projection morphogenesis positive regulation of cell projection organization positive regulation of developmental growth regulation of cell projection organization positive regulation of cell development developmental growth involved in morphogenesis positive regulation of multicellular organismal process regulation of neuron projection development positive regulation of cellular component organization plasma membrane bounded cell projection morphogenesis cell development cell morphogenesis regulation of axon extension regulation of nervous system development regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis positive regulation of axon extension positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth positive regulation of cell growth axon development cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis positive regulation of growth neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size positive regulation of proteasomal protein catabolic process catabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process regulation of primary metabolic process positive regulation of metabolic process positive regulation of ubiquitin-dependent protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process proteolysis positive regulation of macromolecule metabolic process protein metabolic process regulation of protein metabolic process primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process positive regulation of proteolysis regulation of proteasomal protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process metabolic process ubiquitin-dependent protein catabolic process macromolecule metabolic process regulation of metabolic process regulation of protein catabolic process regulation of localization regulation of protein localization regulation of protein export from nucleus regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of nucleocytoplasmic transport regulation of protein transport regulation of cellular localization regulation of intracellular protein transport muscle structure development striated muscle cell differentiation muscle cell differentiation myotube differentiation protein localization to microtubule cytoskeleton regulation of protein localization to centrosome protein localization to microtubule organizing center protein localization to cytoskeleton protein localization to organelle negative regulation of protein localization to centrosome protein localization to centrosome negative regulation of protein localization cell population proliferation positive regulation of cell population proliferation positive regulation of osteoblast proliferation osteoblast proliferation regulation of cell population proliferation regulation of osteoblast proliferation regulation of glycogen biosynthetic process negative regulation of glycogen biosynthetic process glucan biosynthetic process energy derivation by oxidation of organic compounds regulation of glucan biosynthetic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process polysaccharide metabolic process glucan metabolic process regulation of carbohydrate metabolic process negative regulation of carbohydrate metabolic process negative regulation of glycogen metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process glycogen metabolic process negative regulation of metabolic process generation of precursor metabolites and energy glycogen biosynthetic process macromolecule biosynthetic process biosynthetic process negative regulation of biosynthetic process regulation of polysaccharide biosynthetic process negative regulation of macromolecule biosynthetic process energy reserve metabolic process regulation of macromolecule biosynthetic process regulation of carbohydrate biosynthetic process regulation of glycogen metabolic process response to metal ion response to chemical response to zinc ion protein localization to microtubule protein phosphorylation phosphorylation macromolecule modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process fat cell differentiation regulation of epithelial to mesenchymal transition mesenchyme development animal organ development tissue development negative regulation of epithelial to mesenchymal transition epithelial to mesenchymal transition mesenchymal cell differentiation negative regulation of multicellular organismal process regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation response to biotic stimulus intracellular signal transduction cellular response to biotic stimulus ER overload response cellular response to stress response to stress ER-nucleus signaling pathway response to endoplasmic reticulum stress regulation of leukocyte proliferation osteoclast proliferation regulation of osteoclast proliferation positive regulation of osteoclast proliferation leukocyte proliferation positive regulation of leukocyte proliferation calcineurin-NFAT signaling cascade negative regulation of intracellular signal transduction negative regulation of calcineurin-NFAT signaling cascade regulation of intracellular signal transduction intracellular signaling cassette regulation of calcineurin-mediated signaling regulation of calcium-mediated signaling regulation of calcineurin-NFAT signaling cascade negative regulation of calcium-mediated signaling calcium-mediated signaling negative regulation of calcineurin-mediated signaling calcineurin-mediated signaling positive regulation of autophagy autophagy regulation of autophagy process utilizing autophagic mechanism regulation of osteoblast differentiation osteoblast differentiation ossification rhythmic process circadian rhythm regulation of circadian rhythm positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation regulation of peptidyl-threonine phosphorylation positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process peptidyl-amino acid modification peptidyl-threonine modification positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of peptidyl-threonine phosphorylation regulation of phosphorus metabolic process regulation of phosphorylation peptidyl-threonine phosphorylation regulation of mitochondrial membrane potential positive regulation of mitochondrial membrane potential positive regulation of membrane potential regulation of dendrite morphogenesis negative regulation of cellular component organization regulation of dendrite development negative regulation of neurogenesis dendrite development negative regulation of nervous system development negative regulation of cell projection organization negative regulation of dendrite morphogenesis dendrite morphogenesis negative regulation of cell development protein localization to synapse regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to synapse neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to membrane regulation of receptor localization to synapse protein localization to postsynaptic specialization membrane protein localization to cell periphery protein localization to postsynaptic membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane protein-containing complex localization regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to postsynapse protein localization to cell junction receptor localization to synapse regulation of striated muscle cell differentiation regulation of cardiac muscle cell differentiation striated muscle tissue development positive regulation of cardiocyte differentiation positive regulation of striated muscle cell differentiation muscle tissue development positive regulation of cardiac muscle cell differentiation heart development cardiac muscle tissue development cardiac muscle cell differentiation positive regulation of muscle cell differentiation cardiocyte differentiation circulatory system development regulation of muscle cell differentiation regulation of cardiocyte differentiation sexual reproduction reproductive process cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation chromatin organization chromatin remodeling epigenetic programming of gene expression epigenetic regulation of gene expression multicellular organismal reproductive process gene expression genomic imprinting regulation of gene expression autosome genomic imprinting germ cell development response to mechanical stimulus response to external stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus hepatocyte apoptotic process epithelial cell apoptotic process cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to insulin cellular response to insulin stimulus positive regulation of organelle organization plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly cilium assembly cilium organization organelle assembly positive regulation of cellular component biogenesis regulation of cell projection assembly regulation of cellular component biogenesis regulation of organelle organization regulation of plasma membrane bounded cell projection assembly positive regulation of cilium assembly organelle organization regulation of cilium assembly regulation of organelle assembly cell projection assembly positive regulation of plasma membrane bounded cell projection assembly positive regulation of organelle assembly regulation of protein localization to nucleus protein localization to nucleus negative regulation of protein localization to nucleus negative regulation of locomotion regulation of cell motility negative regulation of neuron migration regulation of neuron migration regulation of cell migration cell migration cell motility locomotion negative regulation of cell migration neuron migration regulation of locomotion negative regulation of cell motility positive regulation of neuromuscular junction development neuromuscular junction development regulation of synaptic assembly at neuromuscular junction regulation of synapse structure or activity synapse organization regulation of neuromuscular junction development positive regulation of synaptic assembly at neuromuscular junction regulation of cell junction assembly synapse assembly positive regulation of synapse assembly cell junction assembly regulation of synapse assembly regulation of synapse organization positive regulation of cell junction assembly cell junction organization synaptic assembly at neuromuscular junction apoptotic mitochondrial changes mitochondrial outer membrane permeabilization involved in programmed cell death mitochondrial membrane organization positive regulation of mitochondrial membrane permeability involved in apoptotic process positive regulation of mitochondrial membrane permeability positive regulation of membrane permeability positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrial membrane permeability mitochondrial transport mitochondrion organization membrane organization positive regulation of transport regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of mitochondrion organization regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process mitochondrial outer membrane permeabilization cellular response to amyloid-beta response to amyloid-beta muscle cell apoptotic process smooth muscle cell apoptotic process regulation of muscle cell apoptotic process regulation of smooth muscle cell apoptotic process negative regulation of smooth muscle cell apoptotic process negative regulation of muscle cell apoptotic process protein acylation negative regulation of protein modification process negative regulation of protein metabolic process negative regulation of protein acetylation regulation of protein acetylation protein acetylation positive regulation of macromolecule biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of canonical Wnt signaling pathway negative regulation of Wnt signaling pathway regulation of Wnt signaling pathway negative regulation of canonical Wnt signaling pathway positive regulation of programmed cell death positive regulation of apoptotic process neuron apoptotic process positive regulation of neuron apoptotic process regulation of neuron apoptotic process negative regulation of neuron projection development negative regulation of dendrite development establishment of cell polarity establishment or maintenance of cell polarity fibroblast activation cell activation hepatic stellate cell activation regulation of cellular response to insulin stimulus regulation of insulin receptor signaling pathway negative regulation of cellular response to insulin stimulus negative regulation of insulin receptor signaling pathway signal transduction in absence of ligand extrinsic apoptotic signaling pathway in absence of ligand cytoskeleton organization response to peptide cellular response to interleukin-3 response to cytokine cellular response to cytokine stimulus response to interleukin-3 regulation of neuronal synaptic plasticity negative regulation of TOR signaling TOR signaling regulation of TOR signaling myoblast fusion cell-cell fusion syncytium formation by plasma membrane fusion anatomical structure formation involved in morphogenesis syncytium formation peptidyl-serine modification peptidyl-serine phosphorylation cardiac muscle cell development organ growth striated muscle cell development muscle cell development cardiac muscle hypertrophy cardiac cell development cardiac muscle tissue growth muscle hypertrophy heart growth physiological muscle hypertrophy striated muscle hypertrophy muscle system process cell growth involved in cardiac muscle cell development physiological cardiac muscle hypertrophy cell cycle re-entry into mitotic cell cycle cell cycle process regulation of muscle adaptation negative regulation of muscle hypertrophy regulation of muscle system process regulation of muscle hypertrophy regulation of cardiac muscle hypertrophy muscle adaptation negative regulation of cardiac muscle hypertrophy positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of modification of synaptic structure regulation of modification of postsynaptic structure modification of synaptic structure modification of postsynaptic structure tissue remodeling bone remodeling protein localization to cilium positive regulation of protein localization to cilium regulation of protein localization to cilium positive regulation of protein localization animal organ morphogenesis phosphatidylinositol 3-kinase/protein kinase B signal transduction meiotic cell cycle organelle fission meiotic cell cycle process nuclear division meiosis I meiosis I cell cycle process meiotic nuclear division regulation of neuron maturation negative regulation of neuron maturation cell maturation regulation of cell maturation developmental maturation anatomical structure maturation neuron maturation negative regulation of cell maturation neuron projection organization regulation of cytoskeleton organization microtubule cytoskeleton organization regulation of microtubule-based process microtubule-based process regulation of microtubule cytoskeleton organization positive regulation of nucleocytoplasmic transport positive regulation of establishment of protein localization positive regulation of protein transport positive regulation of intracellular transport positive regulation of protein export from nucleus positive regulation of intracellular protein transport positive regulation of stem cell differentiation stem cell differentiation regulation of stem cell differentiation maintenance of cell polarity intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress intrinsic apoptotic signaling pathway regulation of DNA biosynthetic process positive regulation of DNA biosynthetic process DNA metabolic process positive regulation of DNA metabolic process DNA biosynthetic process regulation of DNA metabolic process response to hepatocyte growth factor cellular response to growth factor stimulus cellular response to hepatocyte growth factor stimulus response to growth factor response to lipid response to glucocorticoid cellular response to organic cyclic compound cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid response to steroid hormone cellular response to lipid cellular response to steroid hormone stimulus response to organic cyclic compound negative regulation of cell junction assembly negative regulation of growth negative regulation of synaptic assembly at neuromuscular junction negative regulation of developmental growth negative regulation of neuromuscular junction development negative regulation of synapse organization negative regulation of synapse assembly myeloid leukocyte differentiation regulation of leukocyte differentiation positive regulation of osteoclast differentiation regulation of osteoclast differentiation positive regulation of hemopoiesis osteoclast differentiation regulation of immune system process positive regulation of immune system process hemopoiesis regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation leukocyte differentiation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol neuron spine synapse neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse cell junction dendrite cellular anatomical structure intracellular anatomical structure cytoplasm cytosol neuron spine synapse neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse cell junction dendrite dendritic tree cell periphery plasma membrane membrane protein-containing complex catalytic complex beta-catenin destruction complex intracellular protein-containing complex Schaffer collateral - CA1 synapse ribonucleoprotein complex membrane-bounded organelle organelle glutamatergic synapse dendritic shaft perinuclear region of cytoplasm cell body neuronal cell body axon polymeric cytoskeletal fiber intracellular membraneless organelle intracellular organelle cytoskeleton membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton mitochondrion intracellular membrane-bounded organelle growth cone distal axon site of polarized growth nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen Wnt signalosome postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse spindle meiotic spindle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR016137	RGS domain	Domain
B	IPR036305	RGS domain superfamily	Homologous Superfamily
B	IPR032101	Axin-1/2, tankyrase-binding domain	Domain
B	IPR044926	RGS, subdomain 2	Homologous Superfamily
B	IPR038207	DIX domain superfamily	Homologous Superfamily
B	IPR024066	RGS, subdomain 1/3	Homologous Superfamily
B	IPR043581	Axin-like	Family
B	IPR014936	Axin beta-catenin binding	Domain
B	IPR001158	DIX domain	Domain
B	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR000719	Protein kinase domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR050591	Glycogen Synthase Kinase-3	Family
A	IPR039192	Glycogen synthase kinase 3, catalytic domain	Domain
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: O15169	caudal duplication hepatocellular carcinoma cancer adult hepatocellular carcinoma endometrium carcinoma in situ liver cancer medulloblastoma prostate adenocarcinoma atypical teratoid rhabdoid tumor colorectal adenocarcinoma hepatoblastoma Hodgkins lymphoma Liver carcinoma osteoporosis psoriasis caudal duplication hepatocellular carcinoma cancer adult hepatocellular carcinoma endometrium carcinoma in situ liver cancer medulloblastoma prostate adenocarcinoma atypical teratoid rhabdoid tumor colorectal adenocarcinoma hepatoblastoma Hodgkins lymphoma Liver carcinoma osteoporosis psoriasis endometrial carcinoma intestinal disease osteosarcoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.